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<jats:title>Background<\/jats:title>\n                    <jats:p>Pericardial adipose tissue (PAT) is a cardiovascular disease risk factor in children, but normative data for PAT thickness, area, and volume are lacking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To establish the percentile reference values for MRI PAT parameters in healthy Chinese children aged 3\u201318.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Type<\/jats:title>\n                    <jats:p>Prospective.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Subjects<\/jats:title>\n                    <jats:p>\n                      218 healthy children divided into 3\u201310\u2009years (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009125, 62 males) and 10\u201318\u2009years (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200993, 53 males).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Field Strength\/Sequence<\/jats:title>\n                    <jats:p>Balanced steady\u2010state free\u2010precession cine sequence at 3.0\u2009T.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Assessment<\/jats:title>\n                    <jats:p>PAT thickness, area and volume.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Statistical Tests<\/jats:title>\n                    <jats:p>\n                      Student's\n                      <jats:italic>t<\/jats:italic>\n                      \u2010test, Mann\u2013Whitney\n                      <jats:italic>U<\/jats:italic>\n                      test, Pearson correlation, the generalized additive model for location scale and shape, and intraclass correlation coefficients (ICC). A\n                      <jats:italic>p<\/jats:italic>\n                      value &lt;\u20090.05 was considered statistically significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      <jats:styled-content style=\"fixed-case\">PAT<\/jats:styled-content>\n                      volume showed no significant sex difference in the overall (boys: 32.7\u2009\u00b1\u200916.2\u2009mL, girls: 28.2\u2009\u00b1\u200910.0\u2009mL,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.179) or childhood group (boys: 22.9\u2009\u00b1\u20097.9 vs. girls: 22.9\u2009\u00b1\u20096.6\u2009mL,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.954), but adolescent boys had a higher volume than girls (44.1\u2009\u00b1\u200915.9 vs. 36.9\u2009\u00b1\u20098.4\u2009mL).\n                      <jats:styled-content style=\"fixed-case\">PAT<\/jats:styled-content>\n                      thickness at the right ventricular free wall (\n                      <jats:styled-content style=\"fixed-case\">RVFW<\/jats:styled-content>\n                      ) was greater in boys across both age groups.\n                      <jats:styled-content style=\"fixed-case\">PAT<\/jats:styled-content>\n                      volume correlated strongly with age (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.672) and\n                      <jats:styled-content style=\"fixed-case\">BSA<\/jats:styled-content>\n                      (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.741). Age\u2010specific percentile curves showed a progressive\n                      <jats:styled-content style=\"fixed-case\">PAT<\/jats:styled-content>\n                      volume increase with no clear plateau, with the most rapid growth between ages 10 and 14.\n                      <jats:styled-content style=\"fixed-case\">BSA<\/jats:styled-content>\n                      \u2010specific curves revealed gradual\n                      <jats:styled-content style=\"fixed-case\">PAT<\/jats:styled-content>\n                      parameter increases, with steeper trends in boys. Good to excellent inter\u2010 and intra\u2010observer agreement was observed for almost all\n                      <jats:styled-content style=\"fixed-case\">PAT<\/jats:styled-content>\n                      parameter measurements (95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      &gt;\u20090.75).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      This study proposes sex\u2010, age\u2010, and\n                      <jats:styled-content style=\"fixed-case\">BSA<\/jats:styled-content>\n                      \u2010specific reference values for pericardial adipose tissue in healthy Chinese children and showed developmental patterns and sex differences that may have potential to inform future clinical and research applications.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Evidence Level<\/jats:title>\n                    <jats:p>2.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Technical Efficacy<\/jats:title>\n                    <jats:p>Stage 2.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jmri.70053","type":"journal-article","created":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T12:33:51Z","timestamp":1756384431000},"page":"1725-1737","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Age\u2010, Body Surface Area\u2010, and Sex\u2010Specific Reference Values for Pericardial Adipose Tissue in Children: An\n                    <scp>MRI<\/scp>\n                    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