{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T12:52:20Z","timestamp":1765889540229,"version":"3.48.0"},"reference-count":50,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T00:00:00Z","timestamp":1755820800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000070","name":"National Institute of Biomedical Imaging and Bioengineering","doi-asserted-by":"publisher","award":["P41 EB017183"],"award-info":[{"award-number":["P41 EB017183"]}],"id":[{"id":"10.13039\/100000070","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P30 AG066512"],"award-info":[{"award-number":["P30 AG066512"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2026,1]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Identifying early neuropathological changes in Alzheimer's disease (AD) is important for improving treatment efficacy. Among quantitative MRI measures, transverse relaxation time (T2) has been shown to reflect tissue microstructure relevant in aging and neurodegeneration; however, findings regarding T2 changes in both normal aging and AD have been inconsistent. The association between T2 and amyloid\u2010beta (A\u03b2) accumulation, a hallmark of AD pathology, is also unclear, particularly in cognitively normal individuals who may be in preclinical stages of the disease.<\/jats:p>\n <\/jats:sec>\n \n Purpose<\/jats:title>\n To investigate longitudinal hippocampal T2 changes in a cognitively normal cohort of older adults and their association with global A\u03b2 accumulation.<\/jats:p>\n <\/jats:sec>\n \n Study Type<\/jats:title>\n Retrospective, longitudinal.<\/jats:p>\n <\/jats:sec>\n \n Subjects<\/jats:title>\n 56 cognitively normal adults between 55 and 90\u2009years of age (17 males and 39 females).<\/jats:p>\n <\/jats:sec>\n \n Field Strength\/Sequence<\/jats:title>\n 3 Tesla; multi\u2010echo spin echo sequence for T2 mapping; 18F\u2010florbetaben positron emission tomography for A\u03b2 measurement.<\/jats:p>\n <\/jats:sec>\n \n Assessment<\/jats:title>\n Bilateral hippocampal T2 and volume were extracted to relate to A\u03b2 PET measurements. To understand variations in AD risk, participants were separated into A\u03b2\u2010high and A\u03b2\u2010low subgroups using a predetermined threshold.<\/jats:p>\n <\/jats:sec>\n \n Statistical Tests<\/jats:title>\n \n Linear mixed\u2010effect models and general linear models were used. A\n p<\/jats:italic>\n \u2010value <\u20090.025 was considered significant to account for bilateral comparisons.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Older age was associated with increased T2 in the bilateral hippocampus (left:\n \u03b2<\/jats:italic>\n \u2009=\u20090.30, right:\n \u03b2<\/jats:italic>\n \u2009=\u20090.25) and smaller hippocampal volume on the left (\n \u03b2<\/jats:italic>\n \u2009=\u2009\u22120.12). In the A\u03b2\u2010low subgroup, both longitudinal T2 increase rates (\n \u03b2<\/jats:italic>\n \u2009=\u20090.65) in the left hippocampus and bilateral cross\u2010sectional T2 (left:\n \u03b2<\/jats:italic>\n \u2009=\u20090.64, right:\n \u03b2<\/jats:italic>\n \u2009=\u20090.46) were positively correlated with A\u03b2 PET, independent of hippocampal volume.\n <\/jats:p>\n <\/jats:sec>\n \n Data Conclusion<\/jats:title>\n This study provided in\u00a0vivo evidence linking hippocampal T2 to A\u03b2 accumulation in cognitively normal aging individuals, suggesting that quantitative T2 may be sensitive to microstructural changes accompanying early A\u03b2 pathology, such as neuroinflammation, demyelination, and reduced tissue integrity.<\/jats:p>\n <\/jats:sec>\n \n Evidence Level<\/jats:title>\n 3.<\/jats:p>\n <\/jats:sec>\n \n Technical Efficacy<\/jats:title>\n Stage 2.<\/jats:p>\n 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