{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T17:07:06Z","timestamp":1770916026109,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,8,30]],"date-time":"2025-08-30T00:00:00Z","timestamp":1756512000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,8,30]],"date-time":"2025-08-30T00:00:00Z","timestamp":1756512000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82471973"],"award-info":[{"award-number":["82471973"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005089","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["7242110"],"award-info":[{"award-number":["7242110"]}],"id":[{"id":"10.13039\/501100005089","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Danon disease (DD), an X\u2010linked disorder due to lysosome\u2010associated membrane protein 2 (LAMP2) mutations, features life\u2010threatening cardiomyopathy. Sex\u2010based cardiac magnetic resonance (cardiac MR) differences are recognized but lack quantitative analysis despite their critical importance in establishing sex\u2010specific diagnostic thresholds and personalized treatment strategies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To investigate sex\u2010based differences in cardiac MR manifestations in DD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Type<\/jats:title>\n                    <jats:p>Retrospective.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Subjects<\/jats:title>\n                    <jats:p>24 DD patients (15 males, 9 females; January 2018\u2013February 2025).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Field Strength\/Sequence<\/jats:title>\n                    <jats:p>3\u2010T, cine imaging (gradient\u2010echo sequence), late gadolinium enhancement (LGE) imaging (inversion\u2010recovery gradient\u2010echo sequence), T1 mapping (modified look\u2010locker inversion\u2010recovery gradient\u2010echo sequence), T2 mapping (gradient\u2010echo sequence with T2 preparation).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Assessment<\/jats:title>\n                    <jats:p>Standardized cardiac MR assessed structural indices (LV volumes\/mass, wall thickness), functional metrics (EF, strain), and tissue characterization (late gadolinium enhancement [LGE extent, T1\/T2 values]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Statistical Tests<\/jats:title>\n                    <jats:p>\n                      Sex comparisons used independent t\u2010tests\/Mann\u2013Whitney\n                      <jats:italic>U<\/jats:italic>\n                      for continuous variables; Chi\u2010square\/Fisher's exact for categorical variables.\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05 significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Males predominantly developed hypertrophic cardiomyopathy (HCM: 73.3%), whereas females universally exhibited dilated cardiomyopathy (DCM: 88.9%) with preserved septal thickness. Ventricular arrhythmias occurred in all females (100% vs. 73.3% in males). Females showed significantly worse left ventricular ejection fraction (LVEF: 37.0%\u2009\u00b1\u200914.0% vs. 49.9%\u2009\u00b1\u200917.9%). Cardiac MR revealed extensive LGE (21.9%\u2009\u00b1\u200911.4%, diffuse free\u2010wall involvement), elevated extracellular volume (ECV) (ECV: 38%\u2009\u00b1\u200912%), and significantly prolonged T1\/T2 values (1374\u2009\u00b1\u200960\u2009ms\/46.5\u2009\u00b1\u20095.4\u2009ms; T1 was higher in females). Global longitudinal strain (GLS: \u22126.5%\u2009\u00b1\u20094.0%), radial strain (GRS: 16.9%\u2009\u00b1\u200912.2%), and circumferential strain (GCS:\n                      <jats:bold>\u221210.6%\u2009\u00b1\u20095.7%<\/jats:bold>\n                      ) were reduced, with significantly worse systolic impairment in females.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Conclusion<\/jats:title>\n                    <jats:p>Sex\u2010specific cardiac MR patterns exist in DD: males predominantly develop HCM, whereas females primarily exhibit DCM, with apical\/free wall LGE observed in both sexes, though mid\u2010basal septum sparing is more frequent in males. These findings enable sex\u2010stratified early diagnosis and phenotype\u2010tailored surveillance, guiding clinical management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Evidence Level<\/jats:title>\n                    <jats:p>4.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Technical Efficacy<\/jats:title>\n                    <jats:p>Stage 2.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jmri.70102","type":"journal-article","created":{"date-parts":[[2025,8,30]],"date-time":"2025-08-30T14:49:06Z","timestamp":1756565346000},"page":"403-414","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Sex\u2010Specific Cardiac Magnetic Resonance Phenotypes in Danon Disease: A Retrospective Cohort Study"],"prefix":"10.1002","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-4046-6221","authenticated-orcid":false,"given":"Ni","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Magnetic Resonance Imaging Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"},{"name":"Department of Radiology The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology  Wuhan Hubei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Magnetic Resonance Imaging Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guijuan","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Radiology The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology  Wuhan Hubei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9797-0625","authenticated-orcid":false,"given":"Zixian","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiology The First Hospital of Lanzhou University  Lanzhou Gansu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3122-992X","authenticated-orcid":false,"given":"Gang","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Magnetic Resonance Imaging Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenhao","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Magnetic Resonance Imaging Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology  Wuhan Hubei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinghui","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Magnetic Resonance Imaging Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minjie","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Magnetic Resonance Imaging Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"},{"name":"Key Laboratory of Cardiovascular Imaging (Cultivation), Chinese Academy of Medical Sciences  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,30]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.31.1.51"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/35022604"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2023.08.014"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGEN.120.003117"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.114.001105"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/64.6.513"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2019.01.020"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/nan.12587"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2021203996"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2012.09.018"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rec.2018.04.035"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.930636"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951111000564"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2011.09.024"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.371"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2017.05.007"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/GIM.0b013e31820ad795"},{"issue":"7","key":"e_1_2_6_19_1","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.124.038394","article-title":"An International Longitudinal Natural History Study of Patients With Danon Disease: Unique Cardiac Trajectories Identified Based on Sex and Heart Failure Outcomes","volume":"14","author":"Hong K. N.","year":"2025","journal-title":"Journal of the American Heart Association"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2020.08.011"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2022774"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx353"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12968-017-0371-5"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crad.2020.04.012"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jev006"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12968-015-0123-3"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2017.07.087"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10038-007-0184-8"}],"container-title":["Journal of Magnetic Resonance Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmri.70102","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jmri.70102","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmri.70102","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T16:05:36Z","timestamp":1770912336000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmri.70102"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,30]]},"references-count":27,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1002\/jmri.70102"],"URL":"https:\/\/doi.org\/10.1002\/jmri.70102","archive":["Portico"],"relation":{},"ISSN":["1053-1807","1522-2586"],"issn-type":[{"value":"1053-1807","type":"print"},{"value":"1522-2586","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,30]]},"assertion":[{"value":"2025-05-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}