{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T11:30:02Z","timestamp":1783769402732,"version":"3.55.0"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T00:00:00Z","timestamp":1757462400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2026,1]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Carotid artery stenosis is a major cause of stroke. Non\u2010contrast MR angiography (MRA) using time\u2010spatial labeling inversion pulse (Time\u2010SLIP) may offer potential advantages over 3D time\u2010of\u2010flight (TOF)\u2010MRA for simultaneous visualization of carotid, vertebral, and subclavian arteries, but remains uninvestigated.<\/jats:p>\n <\/jats:sec>\n \n Purpose<\/jats:title>\n To determine optimal black blood inversion time (TI) for visualizing the carotid and subclavian arteries using three\u2010dimensional (3D) fast field echo (FFE) Time\u2010SLIP MRA, and to compare its image quality with 3D TOF\u2010MRA.<\/jats:p>\n <\/jats:sec>\n \n Study Type<\/jats:title>\n Prospective.<\/jats:p>\n <\/jats:sec>\n \n Subjects<\/jats:title>\n 11 healthy adults (23\u201357\u2009years, five females) and 4 patients (76\u201393\u2009years, three females) with cervical vascular abnormalities. All patients had ICA stenosis. One patient exhibited ECA stenosis.<\/jats:p>\n <\/jats:sec>\n \n Field Strength\/Sequence<\/jats:title>\n 3\u2010T, 3D FFE with Time\u2010SLIP using four TIs (1200\u20131800\u2009ms) for healthy, 3D balanced steady\u2010state free precession (bSSFP) with Time\u2010SLIP using TI\u2009=\u20091600 for patients, and 3D TOF\u2010MRA for all subjects, covering the cervical and subclavian arteries.<\/jats:p>\n <\/jats:sec>\n \n Assessment<\/jats:title>\n For healthy subjects, relative signal intensity (SI) was measured using ROI for both sides of the carotid, vertebral, and subclavian arteries. For the same locations, vessel visibility was independently scored by three board\u2010certified radiologists. Patient images were qualitatively assessed for vessel visibility, abnormality, and artifacts.<\/jats:p>\n <\/jats:sec>\n \n Statistical Tests<\/jats:title>\n \n Friedman and Wilcoxon signed\u2010rank tests for pairwise comparisons of vessel visibility. A Bonferroni\u2010corrected significance threshold of\n p<\/jats:italic>\n \u2009<\u20090.005 (=\u20090.05\/10) was used.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n In volunteer scans, relative SI for TI\u2009=\u20091600 was highest, while TI\u2009=\u20091800 showed the best visibility scores. 3D TOF\u2010MRA showed limitations in subclavian and brachiocephalic arteries due to low vessel\u2010to\u2010background contrast. In patients, FFE\u2010based Time\u2010SLIP provided better subclavian artery depiction than bSSFP\u2010based Time\u2010SLIP.<\/jats:p>\n <\/jats:sec>\n \n Data Conclusion<\/jats:title>\n 3D FFE with Time\u2010SLIP may enable high\u2010quality simultaneous visualization of the carotid and subclavian arteries when compared to 3D TOF\u2010MRA. In patients with vascular abnormalities, 3D FFE may provide superior subclavian artery depiction compared to 3D TOF\u2010MRA and 3D bSSFP.<\/jats:p>\n <\/jats:sec>\n \n Evidence Level<\/jats:title>\n 2.<\/jats:p>\n <\/jats:sec>\n \n Technical Efficacy<\/jats:title>\n Stage 2.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/jmri.70112","type":"journal-article","created":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T14:36:25Z","timestamp":1757514985000},"page":"207-219","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Simultaneous Visualization of the Carotid and Subclavian Arteries Using Non\u2013Contrast\u2010Enhanced\n MR<\/scp>\n Angiography With a\n 3D<\/scp>\n Fast Field Echo Sequence and Time\u2010Spatial Labeling Inversion Pulse: A Comparison With\n 3D<\/scp>\n Time\u2010of\u2010Flight\n MR<\/scp>\n Angiography"],"prefix":"10.1002","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0492-1590","authenticated-orcid":false,"given":"Hitomi","family":"Numamoto","sequence":"first","affiliation":[{"name":"Division of Clinical Radiology Service Kyoto University Hospital Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Fujimoto","sequence":"additional","affiliation":[{"name":"Advanced Imaging in Medical Magnetic Resonance Kyoto University Graduate School of Medicine Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0831-195X","authenticated-orcid":false,"given":"Sachi","family":"Okuchi","sequence":"additional","affiliation":[{"name":"Advanced Imaging in Medical Magnetic Resonance Kyoto University Graduate School of Medicine Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanae K.","family":"Miyake","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging and Nuclear Medicine Kyoto University Graduate School of Medicine Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1982-3168","authenticated-orcid":false,"given":"Yasutaka","family":"Fushimi","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging and Nuclear Medicine Kyoto University Graduate School of Medicine Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takakuni","family":"Maki","sequence":"additional","affiliation":[{"name":"Department of Neurology, Graduate School of Medicine Kyoto University Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichiro","family":"Monzen","sequence":"additional","affiliation":[{"name":"Division of Clinical Radiology Service Kyoto University Hospital Kyoto Japan"},{"name":"Advanced Imaging in Medical Magnetic Resonance Kyoto University Graduate School of Medicine Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rimika","family":"Imai","sequence":"additional","affiliation":[{"name":"Canon Medical Systems Corporation Otawara Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuyasu","family":"Ichinose","sequence":"additional","affiliation":[{"name":"Canon Medical Systems Corporation Otawara Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Nakamoto","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging and Nuclear Medicine Kyoto University Graduate School of Medicine Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000341410"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60153-6"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200103223441206"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0000000000000211"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacr.2024.02.015"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2022.4835"},{"issue":"2","key":"e_1_2_8_8_1","first-page":"103","article-title":"Diagnosis and Treatment of Proximal Carotid Lesions","volume":"13","author":"Clair D. 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