{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T12:29:44Z","timestamp":1770812984960,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T00:00:00Z","timestamp":1759449600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T00:00:00Z","timestamp":1759449600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["Hanuman ANR\u201018\u2010CE45\u20130014"],"award-info":[{"award-number":["Hanuman ANR\u201018\u2010CE45\u20130014"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["CALCOCIMO ANR\u201023\u2010CE18\u20100026"],"award-info":[{"award-number":["CALCOCIMO ANR\u201023\u2010CE18\u20100026"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["EquipEX FIGURES 10\u2010EQPX\u20100001"],"award-info":[{"award-number":["EquipEX FIGURES 10\u2010EQPX\u20100001"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2026,3]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Ventricular enlargement and abnormal cerebrospinal fluid (CSF) circulation are closely associated in communicating hydrocephalus (NPH), yet their causal relationship remains unclear. Studying healthy populations may help clarify these mechanisms. Existing metrics for CSF dynamics and ventricular morphology are limited by physiological variability such as heart rate and brain size, and aqueductal resistance has been little studied in healthy cohorts.<\/jats:p>\n <\/jats:sec>\n \n Purpose<\/jats:title>\n To quantify aqueductal resistance and two ratio\u2010based indices\u2014the CSF stroke volume ratio of the aqueduct to the cervical region (Ratio\u2010SV) and the lateral ventricle to total brain area ratio (Ratio\u2010Area)\u2014in a healthy population, and to examine their interrelationships.<\/jats:p>\n <\/jats:sec>\n \n Study Type<\/jats:title>\n Prospective.<\/jats:p>\n <\/jats:sec>\n \n Population<\/jats:title>\n 34 healthy young adults (17 female, 17 male; age, 25.2\u2009\u00b1\u20093.9\u2009years old); 4 NPH patients (2 female, 2 male; age, 50\u201380\u2009years old).<\/jats:p>\n <\/jats:sec>\n \n Field Strength\/Sequence<\/jats:title>\n 3\u2009T MRI with transverse 3D T1\u2010weighted gradient echo, sagittal 3D Balanced Fast Field Echo (BFFE; gradient echo), and 2D CINE Phase Contrast (CINE\u2010PC; gradient echo) sequences.<\/jats:p>\n <\/jats:sec>\n \n Assessment<\/jats:title>\n Aqueductal resistance was measured on BFFE, Ratio\u2010Area on T1\u2010weighted images, and Ratio\u2010SV on CINE\u2010PC. Sex differences were also examined.<\/jats:p>\n <\/jats:sec>\n \n Statistical Tests<\/jats:title>\n \n Wilcoxon test was used for group comparisons, and Spearman's correlation for associations among parameters, with\n p<\/jats:italic>\n \u2009<\u20090.05 considered significant.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n In healthy adults, mean aqueductal resistance was 72\u2009\u00b1\u200942\u2009mPa\u2009s\/mm\n 3<\/jats:sup>\n , Ratio\u2010SV 6.0%\u2009\u00b1\u20092.3% and Ratio\u2010Area 4.5%\u2009\u00b1\u20091.6%. Males exhibited a significantly lower Ratio\u2010Area compared to females (3.9%\u2009\u00b1\u20091.3% vs. 5.2%\u2009\u00b1\u20091.7%). Ratio\u2010SV was unaffected by the cardiac cycle. Aqueductal resistance showed a strong negative correlation with Ratio\u2010SV (\n r<\/jats:italic>\n \u2009=\u2009\u22120.65) but showed no significant correlation with Ratio\u2010Area (\n r<\/jats:italic>\n \u2009=\u2009\u22120.27). Ratio\u2010SV and Ratio\u2010Area were also uncorrelated (\n r<\/jats:italic>\n \u2009=\u20090.08).\n <\/jats:p>\n <\/jats:sec>\n \n Data Conclusion<\/jats:title>\n Ratio\u2010based metrics provide useful parameters for evaluating both ventricular morphology and CSF dynamics by reducing the influence of physiological variations. Combined with aqueductal resistance, these baseline data in healthy adults may contribute to a better understanding of the pathophysiology of NPH.<\/jats:p>\n <\/jats:sec>\n \n Evidence Level<\/jats:title>\n 2.<\/jats:p>\n <\/jats:sec>\n \n Technical Efficacy<\/jats:title>\n Stage 1.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/jmri.70139","type":"journal-article","created":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T04:15:12Z","timestamp":1759551312000},"page":"721-732","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Relationships Between Lateral Ventricle Size, Cerebrospinal Fluid Dynamics, and Aqueductal Resistance in Young Healthy Adults"],"prefix":"10.1002","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0559-6432","authenticated-orcid":false,"given":"Pan","family":"Liu","sequence":"first","affiliation":[{"name":"Medical Image Processing Department CHU Amiens\u2010Picardie University Hospital Amiens France"},{"name":"CHIMERE Ur 7516 Jules Verne University of Picardy Amiens France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-0502-0522","authenticated-orcid":false,"given":"Jiachen","family":"Xie","sequence":"additional","affiliation":[{"name":"Oncology Department CHU Amiens\u2010Picardie University Hospital Amiens France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8106-1950","authenticated-orcid":false,"given":"Kimi","family":"Owashi","sequence":"additional","affiliation":[{"name":"Medical Image Processing Department CHU Amiens\u2010Picardie University Hospital Amiens France"},{"name":"CHIMERE Ur 7516 Jules Verne University of Picardy Amiens France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yann","family":"Attekeble","sequence":"additional","affiliation":[{"name":"University of Lille Lille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Marc","family":"Constans","sequence":"additional","affiliation":[{"name":"Radiology Department CHU Amiens\u2010Picardie University Hospital Amiens France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7779-0034","authenticated-orcid":false,"given":"Cyrille","family":"Capel","sequence":"additional","affiliation":[{"name":"CHIMERE Ur 7516 Jules Verne University of Picardy Amiens France"},{"name":"Neurosurgery Department CHU Amiens\u2010Picardie University Hospital Amiens France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6028-6440","authenticated-orcid":false,"given":"Olivier","family":"Bal\u00e9dent","sequence":"additional","affiliation":[{"name":"Medical Image Processing Department CHU Amiens\u2010Picardie University Hospital Amiens France"},{"name":"CHIMERE Ur 7516 Jules Verne University of Picardy Amiens France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-008-0058-2"},{"issue":"3","key":"e_1_2_8_3_1","article-title":"Diagnosing Idiopathic Normal\u2010Pressure Hydrocephalus","volume":"57","author":"Relkin N.","year":"2005","journal-title":"Neurosurgery"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196507152730301"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.rli.0000100892.87214.49"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLI.0b013e31819a640b"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.13526"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/215989"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12987-021-00243-6"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12987-024-00532-w"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A4340"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2007.12.022"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brain.2024.100101"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12987-019-0159-0"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12987-024-00570-4"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12987-024-00520-0"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.06.018"},{"issue":"2","key":"e_1_2_8_18_1","first-page":"241","article-title":"Quantitative Volumetric Analysis of Brain MR: Normative Database Spanning 5 Decades of Life","volume":"16","author":"Blatter D. 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