{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T18:27:39Z","timestamp":1770834459127,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T00:00:00Z","timestamp":1765497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T00:00:00Z","timestamp":1765497600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["24ck0106892h0002"],"award-info":[{"award-number":["24ck0106892h0002"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2026,3]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Diffusion\u2010weighted imaging (DWI) in breast MRI requires balancing image quality with acquisition time. Reducing scan time without sacrificing diagnostic performance could improve patient comfort and workflow.<\/jats:p>\n <\/jats:sec>\n \n Purpose<\/jats:title>\n To compare 3\u2010scan trace DWI (tDWI) and diagonal DWI (dDWI) for breast lesion evaluation using both phantom and clinical assessments, focusing on image quality metrics and diagnostic performance.<\/jats:p>\n <\/jats:sec>\n \n Study Type<\/jats:title>\n Retrospective comparative study.<\/jats:p>\n <\/jats:sec>\n \n Population<\/jats:title>\n A commercially available breast diffusion phantom (Caliber MRI; Boulder, CO, USA) and 92 consecutive participants were initially enrolled. After excluding 23 due to having no confirmed lesion, and 15 with non\u2010mass lesions, 54 patients (median age 55.5\u2009years, range 21\u201382) were analyzed.<\/jats:p>\n <\/jats:sec>\n \n Field Strength\/Sequence<\/jats:title>\n 3\u2010T, tDWI (120\u2009s) and dDWI (74\u2009s) with identical parameters except for diffusion gradient directions, with dDWI reducing scan time by 38%.<\/jats:p>\n <\/jats:sec>\n \n Assessment<\/jats:title>\n Phantom studies measured apparent diffusion coefficient (ADC) and estimated signal\u2010to\u2010noise ratio (eSNR). Clinical studies evaluated ADC, contrast\u2010to\u2010noise ratio (CNR), and contrast ratio (CR) from ROIs in lesions, normal breast tissue, and fat. Three radiologists scored lesion conspicuity and image quality.<\/jats:p>\n <\/jats:sec>\n \n Statistical Tests<\/jats:title>\n \n Due to non\u2010normal data distribution, the Wilcoxon signed\u2010rank test compared metrics between sequences. The ADC coefficient of variation (CV) was calculated. A\n p<\/jats:italic>\n \u2010value <\u20090.05 was considered significant.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n dDWI significantly improved image quality by reducing artifacts, especially\u00a0those originating from the nipple and in the breast tissue periphery, and slightly better lesion conspicuity. No significant difference was found for eSNR in breast phantom studies (\n p<\/jats:italic>\n \u2009=\u20090.31 for b\u2009=\u20090; and\n p<\/jats:italic>\n \u2009=\u20090.84 for b\u2009=\u2009800\u2009s\/mm\n 2<\/jats:sup>\n ). tDWI demonstrated significantly higher CNR for breast tissue and fat. tDWI also showed lower CR values for tumor\/breast tissue and lower values for tumor\/fat. ADC measurements were similar between techniques (CV\u2009=\u20094.20%).\n <\/jats:p>\n <\/jats:sec>\n \n Data Conclusion<\/jats:title>\n dDWI provides a 38% shorter acquisition time than tDWI while maintaining comparable quantitative performance. dDWI demonstrates improved image quality, particularly in challenging anatomical regions, though tDWI yields higher contrast\u2010to\u2010noise ratio values.<\/jats:p>\n <\/jats:sec>\n \n Evidence Level<\/jats:title>\n 3.<\/jats:p>\n <\/jats:sec>\n \n Technical Efficacy Stage<\/jats:title>\n 2.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/jmri.70155","type":"journal-article","created":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T00:56:14Z","timestamp":1765587374000},"page":"711-718","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Diagonal\n DWI<\/scp>\n : A Time\u2010Efficient Alternative to 3\u2010Scan Trace\n DWI<\/scp>\n for Breast Lesion Evaluation at 3.0\u2010T\n MRI<\/scp>\n \u2014A Phantom Study and Clinical Assessment"],"prefix":"10.1002","volume":"63","author":[{"given":"Yusuke","family":"Jo","sequence":"first","affiliation":[{"name":"Department of Radiology Nagoya University Graduate School of Medicine Nagoya Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Radiology Nagoya University Graduate School of Medicine Nagoya Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1991-2494","authenticated-orcid":false,"given":"Mami","family":"Iima","sequence":"additional","affiliation":[{"name":"Department of Radiology Nagoya University Graduate School of Medicine Nagoya Aichi Japan"},{"name":"Department of Fundamental Development for Advanced Low Invasive Diagnostic Imaging Nagoya University Graduate School of Medicine Nagoya Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5208-2018","authenticated-orcid":false,"given":"Hiroko","family":"Satake","sequence":"additional","affiliation":[{"name":"Department of Radiology Nagoya University Graduate School of Medicine Nagoya Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunhao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiology Nagoya University Graduate School of Medicine Nagoya Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutaka","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Radiological Technology Nagoya University Hospital Nagoya Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoko","family":"Ishigaki","sequence":"additional","affiliation":[{"name":"Department of Radiology Nagoya University Graduate School of Medicine Nagoya Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7486-4782","authenticated-orcid":false,"given":"Ryota","family":"Hyodo","sequence":"additional","affiliation":[{"name":"Department of Radiology Nagoya University Graduate School of Medicine Nagoya Aichi Japan"},{"name":"Department of Fundamental Development for Advanced Low Invasive Diagnostic Imaging Nagoya University Graduate School of Medicine Nagoya Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aki","family":"Mano","sequence":"additional","affiliation":[{"name":"Department of Radiology Nagoya University Graduate School of Medicine Nagoya Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshito","family":"Ichiba","sequence":"additional","affiliation":[{"name":"Siemens Healthcare K.K. Shinagawa\u2010ku Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0214-613X","authenticated-orcid":false,"given":"Shinji","family":"Naganawa","sequence":"additional","affiliation":[{"name":"Department of Radiology Nagoya University Graduate School of Medicine Nagoya Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.06.1403"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.17752"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mric.2013.04.007"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.10.4258"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.2463\/mrms.mp.2022-0056"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.26908"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-019-06510-3"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-015-3807-z"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacr.2008.10.003"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-20-3037"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.18383\/j.tom.2016.00229"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.25705"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.25214"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.2463\/mrms.mp.2020-0021"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21728"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2453062151"},{"key":"e_1_2_9_18_1","first-page":"1235","article-title":"Use of Coefficient of Variation in Assessing Variability of Quantitative Assays","volume":"9","author":"Reed G. 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