{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T19:25:42Z","timestamp":1793042742269,"version":"4.5.0"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T00:00:00Z","timestamp":1761177600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T00:00:00Z","timestamp":1761177600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["20K17144"],"award-info":[{"award-number":["20K17144"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2026,3]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n A detailed evaluation of hemodynamics, supportive morphology, and deformation may help uncover the pathophysiology of hypertrophic obstructive cardiomyopathy (HOCM) and the changes wrought by alcohol septal ablation (ASA).<\/jats:p>\n <\/jats:sec>\n \n Purpose<\/jats:title>\n To investigate the global cardiac volume, myocardial deformation, and hemodynamic characteristics before and during long\u2010term follow\u2010up after ASA in patients with HOCM.<\/jats:p>\n <\/jats:sec>\n \n Study Type<\/jats:title>\n Retrospective.<\/jats:p>\n <\/jats:sec>\n \n Subjects<\/jats:title>\n Twenty\u2010three patients (68.1\u2009\u00b1\u20098.6\u2009years, 21.7% male) with HOCM who underwent MRI before and after ASA.<\/jats:p>\n <\/jats:sec>\n \n Field Strength\/Sequence<\/jats:title>\n A 3T, Two\u2010dimensional fast imaging employing steady\u2010state acquisition, inversion recovery\u2010prepared fast gradient echo sequences, and cine and time\u2010resolved three\u2010dimensional cine phase\u2010contrast (4D flow) MRI.<\/jats:p>\n <\/jats:sec>\n \n Assessment<\/jats:title>\n Global left ventricular (LV) volume by cine, peak strain, and strain rate by myocardial feature\u2010tracking MRI, and hemodynamic characteristics by 4D flow MRI.<\/jats:p>\n <\/jats:sec>\n \n Statistical Tests<\/jats:title>\n \n Paired\n t<\/jats:italic>\n \u2010test and Wilcoxon signed\u2013rank test compared normally and nonnormally distributed data, respectively. Chi\u2010squared or Fisher's exact tests were used to compare categorical data, as appropriate. Pearson's or Spearman's correlation coefficient evaluated the correlations. Statistical significance was set at\n q<\/jats:italic>\n \u2009\u2264\u20090.10 or\n p<\/jats:italic>\n \u2009<\u20090.05.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n In LV long\u2010axis images, the global radial strain increased significantly (16.6%\u2009\u00b1\u20095.8% vs. 20.1%\u2009\u00b1\u20096.8%), whereas the global longitudinal strain decreased significantly after ASA (\u221210.5%\u2009\u00b1\u20093.2% vs. \u221212.1%\u2009\u00b1\u20093.5%). The diastolic LV anterior vortex area increased significantly after ASA (2256.1 [703.6, 4038.4] vs. 3826.1 [1914.3, 4820.1]\u2009mm\n 2<\/jats:sup>\n ). Multiplication of the LV end\u2010diastolic volume index, global circumferential strain, and diastolic radial peak strain rate in LV long\u2010axis images revealed a significant correlation with the diastolic LV anterior vortex area (Rs\u2009=\u20090.43).\n <\/jats:p>\n <\/jats:sec>\n \n Data Conclusions<\/jats:title>\n Feature\u2010tracking and 4D flow MRI revealed improved systolic and diastolic LV function during long\u2010term follow\u2010up after ASA. The diastolic LV vortex was associated with the combined parameters of LV volume and deformation. Comprehensive cardiac MRI may help understand the beneficial effects of ASA.<\/jats:p>\n <\/jats:sec>\n \n Evidence Level<\/jats:title>\n 3.<\/jats:p>\n <\/jats:sec>\n \n Technical Efficacy<\/jats:title>\n Stage 5.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/jmri.70156","type":"journal-article","created":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T17:39:46Z","timestamp":1761241186000},"page":"859-871","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Alcohol Septal Ablation in Hypertrophic Obstructive Cardiomyopathy: Long\u2010Term Follow\u2010Up of Deformations and Hemodynamics"],"prefix":"10.1002","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6934-7932","authenticated-orcid":false,"given":"Kenichiro","family":"Suwa","sequence":"first","affiliation":[{"name":"Division of Cardiology, Internal Medicine III Hamamatsu University School of Medicine Hamamatsu 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