{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T04:04:10Z","timestamp":1773029050147,"version":"3.50.1"},"reference-count":48,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T00:00:00Z","timestamp":1765843200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T00:00:00Z","timestamp":1765843200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Appetite loss is a non\u2010motor symptom in amyotrophic lateral sclerosis (ALS) linked to poorer prognosis. While the hippocampus regulates \u201cmeal memory\u201d, a key cognitive modulator of eating behavior, its structural role in ALS\u2010related appetite loss is unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To determine if hippocampal subfield integrity influences appetite dysregulation in ALS and to evaluate the strength of neuroanatomical versus demographic factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Type<\/jats:title>\n                    <jats:p>Cross\u2010sectional secondary analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Population<\/jats:title>\n                    <jats:p>Thirty\u2010two patients with ALS (mean age: 58.97\u2009\u00b1\u20098.91\u2009years; 24 males) and 22 non\u2010neurodegenerative controls (NNDc) (mean age: 53.86\u2009\u00b1\u20099.98\u2009years; 16 males).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Field Strength\/Sequence<\/jats:title>\n                    <jats:p>3T; 3D T1\u2010weighted magnetization\u2010prepared rapid gradient\u2010echo (MP2RAGE) and 3D T2\u2010weighted turbo spin\u2010echo (T2\u2010SPACE) sequences.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Assessment<\/jats:title>\n                    <jats:p>Appetite was measured using the Council on Nutrition Appetite Questionnaire (CNAQ). Hippocampal subfield volumes (CA1, CA2\/3, CA4\/DG, stratum radiatum\/lacunosum\/moleculare [SRLM], subiculum) and asymmetry indices were segmented from T1w and T2w images using the HIPS automated pipeline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Statistical Tests<\/jats:title>\n                    <jats:p>\n                      Analysis of Covariance (ANCOVA) (adjusting for age, sex, body mass index (BMI), total intracranial volume (TIV), and subfield volumes\/asymmetry) and hierarchical multiple regression analyses were used. Significance was set at\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Patients with ALS (adjusted mean: 29.51\u2009\u00b1\u20090.53) had significantly lower adjusted CNAQ scores compared to controls (adjusted mean: 31.98\u2009\u00b1\u20090.66; mean difference: \u22122.47, partial\n                      <jats:italic>\u03b7<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.195). In the ANCOVA model, left SRLM volume was the only significant neuroanatomical covariate (\n                      <jats:italic>F<\/jats:italic>\n                      [1, 30]\u2009=\u20096.45, partial\n                      <jats:italic>\u03b7<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.177). However, hierarchical regression revealed that age was the only consistent independent predictor of CNAQ scores (\n                      <jats:italic>B<\/jats:italic>\n                      \u2009=\u2009\u22120.158), explaining the largest variance (\u0394\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.165). Hippocampal volumes and asymmetry did not remain significant predictors after adjusting for age (left SRLM:\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.853; SRLM asymmetry:\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.868).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Conclusion<\/jats:title>\n                    <jats:p>Appetite loss is a non\u2010motor symptom in ALS. While associated with lower left SRLM volume at the group level, appetite decline is more robustly and independently associated with advancing age.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Evidence Level<\/jats:title>\n                    <jats:p>3.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Technical Efficacy<\/jats:title>\n                    <jats:p>3.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jmri.70206","type":"journal-article","created":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T05:54:06Z","timestamp":1765950846000},"page":"1067-1078","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hippocampal Subfield Integrity and Age\u2010Driven Neural Correlates of Appetite Loss in Amyotrophic Lateral Sclerosis"],"prefix":"10.1002","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1334-8826","authenticated-orcid":false,"given":"Sadegh","family":"Ghaderi","sequence":"first","affiliation":[{"name":"Department of Neuroscience and Addiction Studies School of Advanced Technologies in Medicine, Tehran University of Medical Sciences  Tehran Iran"},{"name":"Neuromuscular Research Center, Department of Neurology Shariati Hospital, Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2286-9052","authenticated-orcid":false,"given":"Sana","family":"Mohammadi","sequence":"additional","affiliation":[{"name":"Neuromuscular Research Center, Department of Neurology Shariati Hospital, Tehran University of Medical Sciences  Tehran Iran"},{"name":"Department of Medical Sciences School of Medicine, Iran University of Medical Sciences  Tehran Iran"},{"name":"School of Medicine, Hamadan University of Medical Sciences  Hamadan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4762-8746","authenticated-orcid":false,"given":"Sanjay","family":"Kalra","sequence":"additional","affiliation":[{"name":"Neuroscience and Mental Health Institute, University of Alberta  Edmonton Canada"},{"name":"Division of Neurology, Department of Medicine University of Alberta  Edmonton Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,16]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.71"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/21678421.2023.2263868"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-024-12455-5"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom13050863"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1212\/CPJ.0000000000000521"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.2147\/DNND.S120607"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.26749"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcaf111"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2025.105845"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.50869"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2015.09.011"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2021.10.051"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2021.08.008"},{"key":"e_1_2_13_15_1","doi-asserted-by":"crossref","unstructured":"J.Chang P. 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