{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T22:42:50Z","timestamp":1778798570815,"version":"3.51.4"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T00:00:00Z","timestamp":1768867200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T00:00:00Z","timestamp":1768867200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2026,4]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Gadopiclenol is a high\u2010relaxivity contrast agent enabling dose reduction while maintaining image quality. However, comparison with conventional agents remains limited in body MRI.<\/jats:p>\n <\/jats:sec>\n \n Purpose<\/jats:title>\n To intra\u2010individually compare half\u2010dose gadopiclenol and standard\u2010dose gadobenate for image quality and lesion conspicuity in abdominal MRI.<\/jats:p>\n <\/jats:sec>\n \n Study Type<\/jats:title>\n Retrospective.<\/jats:p>\n <\/jats:sec>\n \n Population<\/jats:title>\n One hundred patients (55 men; mean age: 64\u2009\u00b1\u200914\u2009years) who underwent both abdominal MRI with gadobenate (0.1\u2009mmol\/kg) and gadopiclenol (0.05\u2009mmol\/kg) on the same scanner within 12\u2009months.<\/jats:p>\n <\/jats:sec>\n \n Field Strength\/Sequence<\/jats:title>\n \n 1.5T<\/jats:styled-content>\n \/\n 3T<\/jats:styled-content>\n , dynamic\n T1<\/jats:styled-content>\n \u2010weighted imaging pre\u2010contrast, early arterial (\n EAP<\/jats:styled-content>\n ), late arterial (\n LAP<\/jats:styled-content>\n ), portal venous (\n PVP<\/jats:styled-content>\n ), and equilibrium phases (\n EP<\/jats:styled-content>\n ) using\n 3D<\/jats:styled-content>\n fat\u2010suppressed gradient echo sequence.\n <\/jats:p>\n <\/jats:sec>\n \n Assessment<\/jats:title>\n Signal intensity of liver, pancreas, spleen, kidneys, aorta, portal vein, and abdominal lesions was measured on each phase except EAP. Signal\u2010to\u2010noise ratio (SNR), contrast\u2010to\u2010noise ratio (CNR), and magnitude of contrast enhancement (\u0394E) were calculated for organs. In lesions, lesion\u2010to\u2010background ratio (LBR) and \u0394E were calculated. Subjective image quality and lesion conspicuity were assessed by three readers using a 5\u2010point Likert scale.<\/jats:p>\n <\/jats:sec>\n \n Statistical Tests<\/jats:title>\n \n Paired\n t<\/jats:italic>\n \u2010test and Wilcoxon test.\n p<\/jats:italic>\n \u2009<\u20090.05 indicated statistically significant results.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Gadopiclenol yielded significantly higher CNR and SNR for pancreas, portal vein, and kidney in LAP. No significant differences in CNR (\n p:<\/jats:italic>\n 0.372\u20130.858) and SNR (\n p<\/jats:italic>\n : 0.433\u20130.936) were found in PVP. In EP, gadobenate showed higher hepatic CNR, while CNR and SNR of all other organs were comparable (\n p<\/jats:italic>\n : 0.103\u20130.912). Gadopiclenol showed higher pancreatic \u0394E in all enhanced phases. LBR and \u0394E of 21 evaluated lesions were comparable across all phases (\n p<\/jats:italic>\n : 0.100\u20130.821). No significant differences were observed in readers' perception of lesion enhancement (\n p<\/jats:italic>\n : 0.059\u20130.957).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Half\u2010dose gadopiclenol provides comparable subjective image quality and lesion conspicuity to standard\u2010dose gadobenate, with superior pancreatic, kidney, and portal vein enhancement in LAP, and similar performance in PVP and EP.<\/jats:p>\n <\/jats:sec>\n \n Level of Evidence<\/jats:title>\n 4.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/jmri.70207","type":"journal-article","created":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T14:11:21Z","timestamp":1768918281000},"page":"984-995","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Intraindividual Comparison of Half\u2010Dose Gadopiclenol and Standard\u2010Dose Gadobenate Dimeglumine for Contrast\u2010Enhanced Abdominal\n MRI<\/scp>"],"prefix":"10.1002","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6017-8976","authenticated-orcid":false,"given":"Antonella","family":"Del Gaudio","sequence":"first","affiliation":[{"name":"Department of Radiology Duke University Medical Center Durham North Carolina USA"},{"name":"Department of Medical\u2010Surgical Sciences and Translational Medicine Sapienza University of Rome \u2013 Radiology Unit \u2013 Sant'andrea University Hospital Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1197-456X","authenticated-orcid":false,"given":"Domenico","family":"De Santis","sequence":"additional","affiliation":[{"name":"Department of Medical\u2010Surgical Sciences and Translational Medicine Sapienza University of Rome \u2013 Radiology Unit \u2013 Sant'andrea University Hospital Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ludovica","family":"Lofino","sequence":"additional","affiliation":[{"name":"Department of Radiology Duke University Medical Center Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle E.","family":"Kruse","sequence":"additional","affiliation":[{"name":"Department of Radiology Duke University Medical Center Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin R.","family":"Kalisz","sequence":"additional","affiliation":[{"name":"Department of Radiology Duke University Medical Center Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2984-5010","authenticated-orcid":false,"given":"Rajan T.","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Radiology Duke University Medical Center Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Ria","sequence":"additional","affiliation":[{"name":"Center for Virtual Imaging Trials and Clinical Imaging Physics Group, Radiology Department Duke University Health System Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniele","family":"Marin","sequence":"additional","affiliation":[{"name":"Department of Radiology Duke University Medical Center Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,20]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mric.2017.06.011"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.23.30036"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.29181"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.25625"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.29367"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLI.0000000000000563"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLI.0000000000000624"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLI.0000000000000944"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.222612"},{"key":"e_1_2_10_11_1","unstructured":"\u201cFood and Drug Administration. 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