{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T15:45:10Z","timestamp":1780760710245,"version":"3.54.1"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T00:00:00Z","timestamp":1767052800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T00:00:00Z","timestamp":1767052800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01NS041922"],"award-info":[{"award-number":["R01NS041922"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R61NS119434"],"award-info":[{"award-number":["R61NS119434"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["S10OD028724"],"award-info":[{"award-number":["S10OD028724"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Sturge\u2010Weber syndrome (SWS) is a rare neurocutaneous disorder associated with venous capillary malformations, atrophy, and calcifications. Longitudinal imaging is limited by risks of sedation and gadolinium exposure in children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To evaluate whether strategically acquired gradient echo (STAGE), a rapid multi\u2010contrast quantitative MRI method, can reliably detect vascular and parenchymal abnormalities in SWS compared with conventional pre\u2010\/post\u2010contrast MRI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Type<\/jats:title>\n                    <jats:p>Observational cross\u2010sectional.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Population<\/jats:title>\n                    <jats:p>Twenty\u2010two patients with unilateral SWS diagnosed by previous MRI (13 female; ages 2\u201324\u2009years).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Field Strength\/Sequence<\/jats:title>\n                    <jats:p>3T\/T1\u2010weighted (T1W) and T2\u2010weighted (T2W) turbo\u2010spin\u2010echo, fluid attenuated inversion recovery, and a 3D gradient echo\u2010based STAGE sequence providing T1, proton density (PD), T2*, and R2* maps, susceptibility\u2010weighted imaging (SWI), quantitative susceptibility mapping (QSM), T1W with enhanced gray matter to white matter contrast (T1WE), and synthetic images of T2W, FLAIR, and gradient echo images.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Assessment<\/jats:title>\n                    <jats:p>Conventional MRI and STAGE images were reviewed in 10 patients (training group), side\u2010by\u2010side, to determine the STAGE\u2010derived images that identify SWS abnormalities, including leptomeningeal venous capillary malformations (LVCM), enlarged deep medullary veins, choroid plexus enlargement, cerebral atrophy, and calcifications. In the remaining test group of 12 patients, three reviewers scored these abnormalities on STAGE images and compared them with scores from conventional MRI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Statistical Tests<\/jats:title>\n                    <jats:p>\n                      Interrater reliability with intraclass correlation coefficient (ICC), Spearman's rank correlation, Wilcoxon signed\u2010ranked test, Mann\u2013Whitney\n                      <jats:italic>U<\/jats:italic>\n                      \u2010test, Fisher's exact test. Statistical significance level was set as\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      LVCMs were visualized on STAGE with SWI and R2*. Calcifications were differentiated from venous abnormalities using PD, T1WE, synthetic gradient echo, and QSM. STAGE\u2010derived scores had excellent interrater reliability (ICCs &gt;\u20090.90) and were similar to the conventional MRI scores despite some minor differences in some individual cases (total scores from conventional MRI vs. STAGE 8.9 vs. 8.7,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.29).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Conclusion<\/jats:title>\n                    <jats:p>STAGE provided rapid, non\u2010contrast, multi\u2010parametric imaging that reliably detected vascular and parenchymal SWS abnormalities seen on conventional MRI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Evidence Level<\/jats:title>\n                    <jats:p>2.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Technical Efficacy<\/jats:title>\n                    <jats:p>Stage 3.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jmri.70222","type":"journal-article","created":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T12:25:30Z","timestamp":1767097530000},"page":"1270-1281","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinical Validation of a Fast\n                    <scp>MRI<\/scp>\n                    Method to Evaluate Brain Vascular and Parenchymal Abnormalities in Sturge\u2010Weber Syndrome"],"prefix":"10.1002","volume":"63","author":[{"given":"Scotty G.","family":"McKay","sequence":"first","affiliation":[{"name":"Department of Radiology Wayne State University School of Medicine  Detroit Michigan USA"},{"name":"Department of Radiology Detroit Medical Center  Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7114-5731","authenticated-orcid":false,"given":"Yongsheng","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology Wayne State University School of Medicine  Detroit Michigan USA"},{"name":"Department of Biomedical Engineering Wayne State University  Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. Mark","family":"Haacke","sequence":"additional","affiliation":[{"name":"Department of Radiology Wayne State University School of Medicine  Detroit Michigan USA"},{"name":"Department of Neurology Wayne State University School of Medicine  Detroit Michigan USA"},{"name":"Department of Biomedical Engineering Wayne State University  Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Xuan","sequence":"additional","affiliation":[{"name":"Department of Radiology Wayne State University School of Medicine  Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aimee F.","family":"Luat","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Central Michigan University  Mt Pleasant Michigan USA"},{"name":"Division of Neurology Children's Hospital of Michigan  Detroit Michigan USA"},{"name":"Department of Pediatrics Wayne State University School of Medicine  Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5067-5554","authenticated-orcid":false,"given":"Csaba","family":"Juh\u00e1sz","sequence":"additional","affiliation":[{"name":"Department of Neurology Wayne State University School of Medicine  Detroit Michigan USA"},{"name":"Department of Pediatrics Wayne State University School of Medicine  Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2003.12.015"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1213507"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2020.03.978"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddab144"},{"issue":"5","key":"e_1_2_8_6_1","first-page":"900","article-title":"Multimodality Imaging of Cortical and White Matter Abnormalities in Sturge\u2010Weber Syndrome","volume":"28","author":"Juh\u00e1sz C.","year":"2007","journal-title":"American Journal of Neuroradiology"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2022.11.011"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2021.04.013"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9592.2008.02900.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-019-04535-w"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-021-05134-4"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-022-09297-y"},{"issue":"5","key":"e_1_2_8_13_1","first-page":"218","article-title":"Gadolinium Deposition Disease: A Case Report and the Prevalence of Enhanced MRI Procedures Within the Veterans Health Administration","volume":"39","author":"Jackson D. 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