{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T06:03:07Z","timestamp":1775800987260,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T00:00:00Z","timestamp":1769817600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T00:00:00Z","timestamp":1769817600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2026,5]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n The pulsatile expansion of pulmonary vessels carries dynamic cardiopulmonary information that may reveal disease earlier than structural changes alone.<\/jats:p>\n <\/jats:sec>\n \n Purpose<\/jats:title>\n To test (i) intra\u2010 and inter\u2010scan repeatability of dynamic vessel metrics in healthy subjects, and (ii) whether chronic obstructive pulmonary disease (COPD) and postcapillary pulmonary hypertension (PH) exhibit disease\u2010specific differences.<\/jats:p>\n <\/jats:sec>\n \n Study Type<\/jats:title>\n Retrospective, multi\u2010cohort feasibility study with repeatability sub\u2010study.<\/jats:p>\n <\/jats:sec>\n \n Subjects<\/jats:title>\n Healthy: 29 (11 female), COPD: 52 (15 female), PH: 25 (15 female) with isolated postcapillary PH.<\/jats:p>\n <\/jats:sec>\n \n Fieldstrength\/Sequence<\/jats:title>\n 1.5T, free\u2010breathing spoiled gradient\u2010echo sequence, TE\u2009=\u20090.82\u2009ms, TR\u2009=\u20093\u2009ms, flip angle\u2009=\u20095\u00b0.<\/jats:p>\n <\/jats:sec>\n \n Assessment<\/jats:title>\n 2D U\u2010Nets segmented pulmonary vessels throughout each series of 250 images. Dynamic metrics included the coefficient of variation (CV) of vessel area and CV of vessel signal. Delay between vessel signal and vessel expansion as %\u2010of\u2010RR\u2010interval (SE\u2010delay) together with the heart rate and lung area were calculated.<\/jats:p>\n <\/jats:sec>\n \n Statistical Tests<\/jats:title>\n \n Repeatability: Friedman; intraclass correlation coefficient (ICC); standard error of measurement (SEM) and the minimal detectable change (MDC). Group comparisons: Kruskal\u2013Wallis and multiple linear regression.\n p<\/jats:italic>\n \u2009<\u20090.05 was considered significant.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Only the heart rate and the SE\u2010delay presented significant changes across repetitive scans. Differences in Bland\u2013Altman plots were evenly distributed across the range of measurements and symmetrically scattered around zero within 95% confidence intervals (mean bias 0.08%\u20135.12%). Across cohorts, CV vessel area and CV lung area differed significantly, showing lowest variability in COPD (2.67%; 7.03%) and highest in PH (4.58%; 16.74%). SE\u2010delay was significantly prolonged in COPD (81.98%) compared to PH (67.20%) and healthy participants (62.97%). Cohort status (Healthy\/COPD\/PH) remained the strongest significant predictor for all parameters after adjustment (\n F<\/jats:italic>\n \u2010values 4.62\u201334.04), while age and gender had no significant influence (\n p<\/jats:italic>\n \u2009>\u20090.391;\n p<\/jats:italic>\n \u2009>\u20090.069).\n <\/jats:p>\n <\/jats:sec>\n \n Data Conclusion<\/jats:title>\n Free\u2010breathing lung MRI with automated vessel segmentation reveals distinct hemodynamic characteristics in COPD and PH. This method shows potential as a sensitive non\u2010invasive tool for detection, phenotyping, and treatment monitoring in pulmonary pathology.<\/jats:p>\n <\/jats:sec>\n \n Evidence Level<\/jats:title>\n 3.<\/jats:p>\n <\/jats:sec>\n \n Technical Efficacy<\/jats:title>\n 2.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/jmri.70249","type":"journal-article","created":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T22:44:40Z","timestamp":1769899480000},"page":"1420-1432","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Analysis of Pulsatile Vessel Expansion in Healthy,\n COPD<\/scp>\n \u2010 and\n PH<\/scp>\n \u2010Patients Using Dynamic Vessel Segmentation\u00a0in Free\u2010Breathing Lung\n MRI<\/scp>"],"prefix":"10.1002","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1927-9876","authenticated-orcid":false,"given":"Julian","family":"Glandorf","sequence":"first","affiliation":[{"name":"Institute for Diagnostic and Interventional Radiology Hannover Medical School Hannover Germany"},{"name":"Biomedical Research in End\u2010Stage and Obstructive Lung Disease Hannover (BREATH), German Centre for Lung Research (DZL) Hannover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marius M.","family":"Klein","sequence":"additional","affiliation":[{"name":"Institute for Diagnostic and Interventional Radiology Hannover Medical School Hannover Germany"},{"name":"Biomedical Research in End\u2010Stage and Obstructive Lung Disease Hannover (BREATH), German Centre for Lung Research (DZL) Hannover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2715-0757","authenticated-orcid":false,"given":"Filip","family":"Klime\u0161","sequence":"additional","affiliation":[{"name":"Institute for Diagnostic and Interventional Radiology Hannover Medical School Hannover Germany"},{"name":"Biomedical Research in End\u2010Stage and Obstructive Lung Disease Hannover (BREATH), German Centre for Lung Research (DZL) Hannover Germany"},{"name":"Department of Diagnostic and Interventional Radiology Charit\u00e9 Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t Zu Berlin Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4157-9808","authenticated-orcid":false,"given":"Agilo Luitger","family":"Kern","sequence":"additional","affiliation":[{"name":"Institute for Diagnostic and Interventional Radiology Hannover Medical School Hannover Germany"},{"name":"Biomedical Research in End\u2010Stage and Obstructive Lung Disease Hannover (BREATH), German Centre for Lung Research (DZL) Hannover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6164-8973","authenticated-orcid":false,"given":"Marcel","family":"Gutberlet","sequence":"additional","affiliation":[{"name":"Institute for Diagnostic and Interventional Radiology Hannover Medical School Hannover Germany"},{"name":"Biomedical Research in End\u2010Stage and Obstructive Lung Disease Hannover (BREATH), German Centre for Lung Research (DZL) Hannover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2646-6186","authenticated-orcid":false,"given":"Jens M.","family":"Hohlfeld","sequence":"additional","affiliation":[{"name":"Biomedical Research in End\u2010Stage and Obstructive Lung Disease Hannover (BREATH), German Centre for Lung Research (DZL) Hannover Germany"},{"name":"Clinical Airway Research, Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM) Hannover Germany"},{"name":"Department of Respiratory Medicine and Infectious Diseases Hannover Medical School Hannover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marius M.","family":"Hoeper","sequence":"additional","affiliation":[{"name":"Biomedical Research in End\u2010Stage and Obstructive Lung Disease Hannover (BREATH), German Centre for Lung Research (DZL) Hannover Germany"},{"name":"Department of Respiratory Medicine and Infectious Diseases Hannover Medical School Hannover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5302-1548","authenticated-orcid":false,"given":"Karen M.","family":"Olsson","sequence":"additional","affiliation":[{"name":"Biomedical Research in End\u2010Stage and Obstructive Lung Disease Hannover (BREATH), German Centre for Lung Research (DZL) Hannover Germany"},{"name":"Department of Respiratory Medicine and Infectious Diseases Hannover Medical School Hannover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Wacker","sequence":"additional","affiliation":[{"name":"Institute for Diagnostic and Interventional Radiology Hannover Medical School Hannover Germany"},{"name":"Biomedical Research in End\u2010Stage and Obstructive Lung Disease Hannover (BREATH), German Centre for Lung Research (DZL) Hannover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens","family":"Vogel\u2010Claussen","sequence":"additional","affiliation":[{"name":"Institute for Diagnostic and Interventional Radiology Hannover Medical School Hannover Germany"},{"name":"Biomedical Research in End\u2010Stage and Obstructive Lung Disease Hannover (BREATH), German Centre for Lung Research (DZL) Hannover Germany"},{"name":"Department of Diagnostic and Interventional Radiology Charit\u00e9 Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t Zu Berlin Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Voskrebenzev","sequence":"additional","affiliation":[{"name":"Institute for Diagnostic and Interventional Radiology Hannover Medical School Hannover Germany"},{"name":"Biomedical Research in End\u2010Stage and Obstructive Lung Disease Hannover (BREATH), German Centre for Lung Research (DZL) Hannover Germany"},{"name":"Department of Diagnostic and Interventional Radiology Charit\u00e9 Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t Zu Berlin Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,31]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.26893"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.3134"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.26096"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-031-95322-4_2"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2015.06.005"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00879-2022"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.10.036"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00015608"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(18)30054-7"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-2145-4756"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/1532-429X-15-S1-O62"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2006.03.008"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/echo.12170"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.4029"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00440.2024"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-024-11209-1"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00831-2019"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.29337"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201805-0995OC"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2020.00051"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.28995"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-24574-4_28"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1148\/ryct.230104"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2025.111316"},{"issue":"210","key":"e_1_2_9_26_1","first-page":"66380","article-title":"Phase\u2010Resolved Functional Lung MRI for Pulmonary Ventilation and Perfusion (V\/Q) Assessment","author":"Voskrebenzev A.","year":"2024","journal-title":"JoVE"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcm.2016.02.012"},{"key":"e_1_2_9_28_1","volume-title":"Statistical Power Analysis for the Behavioral Sciences","author":"Cohen J.","year":"2009"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.143.6.1157"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910140205"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.23581"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/6.suppl_C.43"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201509-599FR"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/26.9.839"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-37078-6_202"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2010.212787"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2016.03.001"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnmrs.2020.11.002"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.120.14515"}],"container-title":["Journal of Magnetic Resonance Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmri.70249","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jmri.70249","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmri.70249","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T05:12:35Z","timestamp":1775797955000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmri.70249"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,31]]},"references-count":38,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1002\/jmri.70249"],"URL":"https:\/\/doi.org\/10.1002\/jmri.70249","archive":["Portico"],"relation":{},"ISSN":["1053-1807","1522-2586"],"issn-type":[{"value":"1053-1807","type":"print"},{"value":"1522-2586","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,31]]},"assertion":[{"value":"2025-11-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}