{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T11:02:20Z","timestamp":1780743740346,"version":"3.54.1"},"reference-count":49,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T00:00:00Z","timestamp":1770681600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T00:00:00Z","timestamp":1770681600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DK117459"],"award-info":[{"award-number":["R01DK117459"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01CA278923\u201001"],"award-info":[{"award-number":["U01CA278923\u201001"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2026,6]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Noninvasive detection of chronic pancreatitis (CP) is important for proper treatment and prevention of severe pain and pancreatic insufficiency.<\/jats:p>\n <\/jats:sec>\n \n Purpose<\/jats:title>\n \n To evaluate if T\n 1<\/jats:sub>\n \u03c1 MRF is significantly different in healthy volunteers and patients with CP.\n <\/jats:p>\n <\/jats:sec>\n \n Study Type<\/jats:title>\n Prospective.<\/jats:p>\n <\/jats:sec>\n \n Population<\/jats:title>\n Seventeen healthy volunteers (9 male, mean age: 38.0\u2009\u00b1\u20096.7\u2009years) and 20 patients (12 male, mean age: 53.6\u2009\u00b1\u20096.4\u2009years) who were clinically diagnosed with CP.<\/jats:p>\n <\/jats:sec>\n \n Field Strength\/Sequence<\/jats:title>\n \n 3\u2009T, T\n 1<\/jats:sub>\n \u03c1 MRF acquired during breath\u2010hold (BH\u2010MRF) and free breathing (FB\u2010MRF), conventional T\n 1<\/jats:sub>\n \/T\n 2<\/jats:sub>\n mapping sequences.\n <\/jats:p>\n <\/jats:sec>\n \n Assessment<\/jats:title>\n \n Mean T\n 1<\/jats:sub>\n \/T\n 2<\/jats:sub>\n \/T\n 1<\/jats:sub>\n \u03c1 values in the whole pancreas were compared between diagnosed CP patients and controls. The Cambridge classification (CC) score was used to divide patients into mild\u2013moderate (CC\u2009=\u20091\u20133) and severe (CC\u2009=\u20094) CP subgroups. T\n 1<\/jats:sub>\n , T\n 2<\/jats:sub>\n , and T\n 1<\/jats:sub>\n \u03c1 relaxation maps were generated from both breath\u2010hold (BH) and free\u2010breathing (FB) MRF data.\n <\/jats:p>\n <\/jats:sec>\n \n Statistical Tests<\/jats:title>\n \n Mixed effects models were calculated for healthy control versus CP, and between mild\u2013moderate and severe CP. Receiver operator characteristic (ROC) curves were analyzed and areas under the curves (AUCs) were calculated. A\n p<\/jats:italic>\n \u2010value <\u20090.05 was considered significant and multiple comparison corrections were applied.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n BH\u2010MRF T\n 1<\/jats:sub>\n \/T\n 2<\/jats:sub>\n \/T\n 1<\/jats:sub>\n \u03c1 values were significantly higher in the CP group (1327.3, 48.6, 49.1\u2009ms) compared to healthy controls (821.6, 41.6, 39.5\u2009ms) with AUCs of 0.994, 0.873, and 0.862, respectively. The MRF BH T\n 1<\/jats:sub>\n \/T\n 2<\/jats:sub>\n \/T\n 1<\/jats:sub>\n \u03c1 values of mild\u2013moderate CP (\n N<\/jats:italic>\n \u2009=\u20097) and severe CP (\n N<\/jats:italic>\n \u2009=\u200913) patients were also significantly higher compared to healthy controls. T\n 1<\/jats:sub>\n was significantly higher in severe CP compared to mild\u2013moderate CP (1497 and 1012.1\u2009ms, respectively) with AUC\u2009=\u20090.945. FB MRF T\n 1<\/jats:sub>\n relaxation times demonstrated good correlation with BH values (0.981), while T\n 2<\/jats:sub>\n and T\n 1<\/jats:sub>\n \u03c1 had moderate correlations (0.507 and 0.697, respectively).\n <\/jats:p>\n <\/jats:sec>\n \n Data Conclusions<\/jats:title>\n \n T\n 1<\/jats:sub>\n , T\n 2<\/jats:sub>\n , and T\n 1<\/jats:sub>\n \u03c1 relaxation times have potential for noninvasively assessing CP.\n <\/jats:p>\n <\/jats:sec>\n \n Evidence Level<\/jats:title>\n 2.<\/jats:p>\n <\/jats:sec>\n \n Technical Efficacy<\/jats:title>\n Stage 2.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/jmri.70251","type":"journal-article","created":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T12:37:41Z","timestamp":1770727061000},"page":"1662-1672","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["T\n 1<\/sub>\n \u03c1 Magnetic Resonance Fingerprinting in Patients With Chronic Pancreatitis"],"prefix":"10.1002","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4271-9681","authenticated-orcid":false,"given":"Omar","family":"Kamal","sequence":"first","affiliation":[{"name":"Department of Diagnostic Radiology Oregon Health & Science University Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2123-7854","authenticated-orcid":false,"given":"Kaveh","family":"Sharzehi","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Gastroenterology and Hepatology Oregon Health & Science University Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brett","family":"Sheppard","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Gastrointestinal and General Surgery Oregon Health & Science University Portland Oregon 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