{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T11:02:16Z","timestamp":1780743736475,"version":"3.54.1"},"reference-count":49,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T00:00:00Z","timestamp":1769990400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T00:00:00Z","timestamp":1769990400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971111"],"award-info":[{"award-number":["81971111"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371331"],"award-info":[{"award-number":["82371331"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82401545"],"award-info":[{"award-number":["82401545"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2022QH363"],"award-info":[{"award-number":["ZR2022QH363"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2026,6]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Cerebral small vessel disease (CSVD) is an important risk factor for stroke and cognitive impairment, adversely affecting long\u2010term outcomes. Methylglyoxal (MGO), a by\u2010product of glycolysis, is implicated in various vascular complications.<\/jats:p>\n <\/jats:sec>\n \n Purpose<\/jats:title>\n To explore the correlation between MGO and CSVD, particularly with white matter hyperintensities (WMH).<\/jats:p>\n <\/jats:sec>\n \n Study Type<\/jats:title>\n Prospective.<\/jats:p>\n <\/jats:sec>\n \n Population<\/jats:title>\n One hundred and fifteen patients with first\u2010ever small artery occlusion (SAO) within 72\u2009h of onset were enrolled, with a mean age of 63.83\u2009\u00b1\u200910.92\u2009years, of whom 75 (65.2%) were male.<\/jats:p>\n <\/jats:sec>\n \n Field Strength\/Sequence<\/jats:title>\n 1.5T or 3T; fast spin\u2010echo for T1\u2010 and T2\u2010weighted imaging, fluid\u2010attenuated inversion recovery (FLAIR), diffusion\u2010weighted imaging (DWI), and susceptibility\u2010weighted imaging (SWI).<\/jats:p>\n <\/jats:sec>\n \n Assessment<\/jats:title>\n Two neurologists independently evaluated the conventional MRI biomarkers of CSVD, including WMH, enlarged perivascular spaces, lacunes (LAC), and cerebral microbleeds; fasting blood samples were collected both within 72\u2009h and between 8 and 14\u2009days after the onset of the disease to measure MGO.<\/jats:p>\n <\/jats:sec>\n \n Statistical Tests<\/jats:title>\n \n T<\/jats:italic>\n \u2010test, Wilcoxon Mann\u2013Whitney test, chi\u2010square test, Spearman correlation analysis, ANOVA or the Kruskal\u2013Wallis test; logistic regression analysis, intraclass correlation coefficient (ICC).\n p<\/jats:italic>\n \u2009<\u20090.05 was considered statistically significant.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Elevated MGO levels at admission were independently associated with CSVD (odds ratio [OR] 1.007, 95% confidence interval [CI] 1.002\u20131.011), and the severity of WMH (OR 1.004, 95% CI 1.001\u20131.008) and deep white matter hyperintensities (D\u2010WMH) (OR 1.004, 95% CI 1.000\u20131.007). MGO levels also showed\u00a0a positive correlation with LAC (correlation coefficient [\n r<\/jats:italic>\n ]\u2009=\u20090.225) but no significant correlation with periventricular white matter hyperintensities (PV\u2010WMH) (\n r<\/jats:italic>\n \u2009=\u20090.172,\n p<\/jats:italic>\n \u2009=\u20090.066). Furthermore, there was no significant difference in MGO levels between admission and discharge (\n t<\/jats:italic>\n \u2009=\u20091.932,\n p<\/jats:italic>\n \u2009=\u20090.056). The reproducibility of MRI parameters was excellent (ICC 0.966\u20130.976).\n <\/jats:p>\n <\/jats:sec>\n \n Data Conclusion<\/jats:title>\n Elevated MGO levels in patients with first\u2010ever SAO were associated with the presence and severity of WMH, particularly D\u2010WMH.<\/jats:p>\n <\/jats:sec>\n \n Level of Evidence<\/jats:title>\n 1<\/jats:p>\n <\/jats:sec>\n \n Technical Efficacy<\/jats:title>\n Stage 1<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/jmri.70252","type":"journal-article","created":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T19:34:07Z","timestamp":1770060847000},"page":"1562-1575","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association Between Plasma Methylglyoxal and White Matter Hyperintensities in\n MR<\/scp>\n in Acute Ischemic Stroke Patients With Small Artery 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