{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T11:02:16Z","timestamp":1780743736549,"version":"3.54.1"},"reference-count":42,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T00:00:00Z","timestamp":1770595200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T00:00:00Z","timestamp":1770595200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2406903"],"award-info":[{"award-number":["2022YFC2406903"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U22A20354"],"award-info":[{"award-number":["U22A20354"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2026,6]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n \n 31<\/jats:sup>\n P magnetic resonance spectroscopy (\n 31<\/jats:sup>\n P\u2010MRS) allows non\u2010invasive assessment of mitochondrial function by quantifying metabolites of energy and phospholipid metabolism, but the association between these metabolic alterations and motor laterality in Parkinson's disease (PD) remains unknown.\n <\/jats:p>\n <\/jats:sec>\n \n Purpose<\/jats:title>\n \n To investigate the association between mitochondrial dysfunction and motor symptom lateralization in PD using\n 31<\/jats:sup>\n P\u2010MRS.\n <\/jats:p>\n <\/jats:sec>\n \n Study Type<\/jats:title>\n Retrospective.<\/jats:p>\n <\/jats:sec>\n \n Population<\/jats:title>\n 34 PD patients with left\u2010sided predominance (LPD; 20\u2009M\/14\u2009F), 35 PD patients with right\u2010sided predominance (RPD; 16\u2009M\/19\u2009F), and 43 healthy controls (HCs; 20\u2009M\/23\u2009F).<\/jats:p>\n <\/jats:sec>\n \n Fieldstrength\/Sequence<\/jats:title>\n 3T; 3D T1\u2010weighted gradient\u2010echo and 2D FID\u2010based chemical shift imaging sequences.<\/jats:p>\n <\/jats:sec>\n \n Assessment<\/jats:title>\n \n 31<\/jats:sup>\n P\u2010MRS spectra from bilateral putamen, frontal, and temporoparietal cortices were quantified for adenosine triphosphate (ATP), phosphocreatine (PCr), inorganic phosphate (Pi), phosphomonoesters (PME), and phosphodiesters (PDE). Metabolite levels were corrected for cerebrospinal fluid (CSF) partial volume effects. Metabolic ratios and laterality indices (LIs) were calculated and correlated with motor symptom LIs.\n <\/jats:p>\n <\/jats:sec>\n \n Statistical Tests<\/jats:title>\n \n General linear models, spearman's rank correlation, and receiver operating characteristic (ROC) analysis.\n p<\/jats:italic>\n \u2009<\u20090.05 was considered statistically significant.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n RPD<\/jats:styled-content>\n patients exhibited significantly elevated\n ATP<\/jats:styled-content>\n (0.181\u2009\u00b1\u20090.005) and reduced\n PCr<\/jats:styled-content>\n \/\n ATP<\/jats:styled-content>\n (0.979\u2009\u00b1\u20090.033) in the left putamen compared to\n HCs<\/jats:styled-content>\n (0.164\u2009\u00b1\u20090.004; 1.098\u2009\u00b1\u20090.030); they also showed a significantly lower frontal\n PDE LI<\/jats:styled-content>\n (\u22120.069\u2009\u00b1\u20090.022), higher temporoparietal Pi\n LI<\/jats:styled-content>\n (0.086\u2009\u00b1\u20090.039), and reduced\n PCr<\/jats:styled-content>\n \/Pi\n LI<\/jats:styled-content>\n (\u22120.106\u2009\u00b1\u20090.041) relative to\n LPD<\/jats:styled-content>\n patients (\u22120.019\u2009\u00b1\u20090.022; \u22120.075\u2009\u00b1\u20090.040; 0.047\u2009\u00b1\u20090.042). In the temporoparietal cortex, the\n LIs<\/jats:styled-content>\n of\n PCr<\/jats:styled-content>\n \/Pi (\n r<\/jats:italic>\n \u2009=\u20090.260),\n PME<\/jats:styled-content>\n \/\n PDE<\/jats:styled-content>\n (\n r<\/jats:italic>\n \u2009=\u20090.323), and Pi (\n r<\/jats:italic>\n \u2009=\u2009\u22120.315) were significantly correlated with the\n LIs<\/jats:styled-content>\n of\n UPDRS<\/jats:styled-content>\n \u2010\n III<\/jats:styled-content>\n scores. The Pi\n LI<\/jats:styled-content>\n in the temporoparietal cortex showed a promising ability to distinguish\n LPD<\/jats:styled-content>\n from\n RPD<\/jats:styled-content>\n patients (\n AUC<\/jats:styled-content>\n \u2009=\u20090.709).\n <\/jats:p>\n <\/jats:sec>\n \n Data Conclusion<\/jats:title>\n \n Asymmetrical mitochondrial dysfunction, detected by\n 31<\/jats:sup>\n P\u2010MRS, correlates with motor symptom laterality in PD. These metabolic asymmetries may serve as the underlying basis for symptom lateralization.\n <\/jats:p>\n <\/jats:sec>\n \n Evidence Level<\/jats:title>\n 3.<\/jats:p>\n <\/jats:sec>\n \n Technical Efficacy<\/jats:title>\n Stage 1.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/jmri.70265","type":"journal-article","created":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T11:58:11Z","timestamp":1770638291000},"page":"1576-1585","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Asymmetrical Cerebral Mitochondrial Dysfunction Correlates With Motor Laterality in Parkinson's Disease: A\n \n 31<\/sup>\n Phosphorus\n <\/scp>\n Magnetic Resonance Spectroscopy Study"],"prefix":"10.1002","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-6114-0121","authenticated-orcid":false,"given":"Bing Fang","family":"Duan","sequence":"first","affiliation":[{"name":"Department of Radiology, Tongji Hospital, Tongji Medical 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