{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T11:02:17Z","timestamp":1780743737916,"version":"3.54.1"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T00:00:00Z","timestamp":1771286400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T00:00:00Z","timestamp":1771286400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2026,6]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n One manifestation of multiple sclerosis (MS) is abnormal iron\u2010related susceptibility changes in deep gray matter (DGM), contributing to oxidative stress and neurodegeneration. Intermittent fasting (IF) is a metabolic intervention that may influence inflammatory and iron\u2010related pathways.<\/jats:p>\n <\/jats:sec>\n \n Purpose<\/jats:title>\n To compare susceptibility\u2010derived phase values in DGM between fasting and non\u2010fasting periods in patients with MS.<\/jats:p>\n <\/jats:sec>\n \n Study Type<\/jats:title>\n Retrospective observational cohort study.<\/jats:p>\n <\/jats:sec>\n \n Population<\/jats:title>\n \n 36 patients with MS were studied: a fasting group (\n n<\/jats:italic>\n \u2009=\u200920; mean age 33.1\u2009\u00b1\u20099.6\u2009years; 14 males), a non\u2010fasting control group (\n n<\/jats:italic>\n \u2009=\u200914; mean age 34.9\u2009\u00b1\u200910.8\u2009years; 10 males), and two cases with additional measurements.\n <\/jats:p>\n <\/jats:sec>\n \n Field Strength\/Sequence<\/jats:title>\n 1.5\u2009T; Echo Planar Susceptibility\u2010Weighted Imaging (EPI\u2010SWI).<\/jats:p>\n <\/jats:sec>\n \n Assessment<\/jats:title>\n Paramagnetic mean phase values (pMPVs) were measured in nine bilateral DGM regions at 2 time points separated by a 1\u2010year interval.<\/jats:p>\n <\/jats:sec>\n \n Statistical Tests<\/jats:title>\n \n Paired and independent\n t<\/jats:italic>\n \u2010tests were used to analyze phase value changes; a\n p<\/jats:italic>\n \u2010value of less than 0.05 was considered statistically significant.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Inter\u2010rater reliability was high (ICC\u2009=\u20090.91). The fasting group had lower pMPVs at the second time compared to the first (48.91\u2009\u00b1\u200910.45 vs. 38.38\u2009\u00b1\u200911.23; mean difference \u221210.53; 95% CI: \u221213.28 to \u22127.78), with consistent reductions across all subregions. The non\u2010fasting group showed the opposite pattern (45.42\u2009\u00b1\u200919.98 vs. 52.99\u2009\u00b1\u200921.05; 95% CI: 4.71 to 10.43), while bilateral thalamic values remained stable (left\n p<\/jats:italic>\n \u2009=\u20090.104; right\n p<\/jats:italic>\n \u2009=\u20090.938). Serial case studies are associated with temporal patterns in pMPVs during fasting and non\u2010fasting intervals.\n <\/jats:p>\n <\/jats:sec>\n \n Data Conclusion<\/jats:title>\n Measurements during fasting periods were associated with lower pMPVs in DGM in multiple sclerosis compared to non\u2010fasting periods.<\/jats:p>\n <\/jats:sec>\n \n Level of Evidence<\/jats:title>\n 3.<\/jats:p>\n <\/jats:sec>\n \n Technical Efficacy<\/jats:title>\n Stage 3.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/jmri.70267","type":"journal-article","created":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T12:17:26Z","timestamp":1771330646000},"page":"1639-1649","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Association Between Intermittent Fasting and Susceptibility\u2010Weighted\n MRI<\/scp>\n Phase Values in Deep Gray Matter of Patients With Multiple Sclerosis: An Observational Cohort Study"],"prefix":"10.1002","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7424-8258","authenticated-orcid":false,"given":"Mahmoud R.","family":"Hamed","sequence":"first","affiliation":[{"name":"Biophysics Lab, Physics Department, Faculty of Science Al\u2010Azhar University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2842-1360","authenticated-orcid":false,"given":"Yasser F.","family":"Ali","sequence":"additional","affiliation":[{"name":"Biophysics Lab, Physics Department, Faculty of Science Al\u2010Azhar University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud A.","family":"Kenawy","sequence":"additional","affiliation":[{"name":"Biophysics Lab, Physics Department, Faculty of Science Al\u2010Azhar University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3822-6788","authenticated-orcid":false,"given":"Mohamed","family":"El\u2010Samahy","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medicine Suez Canal University Ismailia Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khairy T.","family":"Ereiba","sequence":"additional","affiliation":[{"name":"Biophysics Lab, Physics Department, Faculty of Science Al\u2010Azhar University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Eissa","sequence":"additional","affiliation":[{"name":"Biophysics Lab, Physics Department, Faculty of Science Al\u2010Azhar University Cairo 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