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In single\u2010center studies, IVIM has shown great potential for diagnosis, treatment outcome prediction, and treatment monitoring for many different diseases and organs. However, heterogeneity in data acquisition protocols, pre\u2010processing pipelines, and post\u2010processing routines yields differences in reported IVIM parameters, which has constrained large\u2010scale deployment of IVIM. Moreover, deploying IVIM protocols and analysis typically requires technical expertise, further challenging wider use, especially for clinicians. In this consensus paper, to accelerate the deployment of IVIM, we provide recommendations and harmonize protocols for brain, breast, kidney, liver, muscle, and pancreas IVIM studies. For this goal we organized multiple questionnaires and held a dedicated workshop. To ensure a level of standardized, reproducible results, without restricting innovation, we suggest a small subset of\n                    <jats:italic>b<\/jats:italic>\n                    \u2010values to always be measured and analyzed separately, and to which more extensive\n                    <jats:italic>b<\/jats:italic>\n                    \u2010value sampling can be added for advanced investigations. We further introduce detailed recommendations on acquisition protocols and analysis pipelines. To increase consistency, repeatability, and reproducibility, we highly recommend that these protocols and pipelines be deployed by scientists and clinicians for IVIM studies. For advanced users who desire different protocols or analysis approaches, we suggest adding results from our suggested protocols and analysis pipeline in the supplemental part of their paper to enable retrospective studies.\n                  <\/jats:p>","DOI":"10.1002\/jmri.70278","type":"journal-article","created":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T08:53:51Z","timestamp":1773910431000},"page":"1782-1801","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Towards Clinical Translation of Intravoxel Incoherent Motion\n                    <scp>MRI<\/scp>\n                    : Acquisition and Analysis Consensus Recommendations"],"prefix":"10.1002","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6783-3611","authenticated-orcid":false,"given":"Eric E.","family":"Sigmund","sequence":"first","affiliation":[{"name":"Department of Radiology NYU Langone Health  New York New York USA"},{"name":"Bernard and Irene Schwartz Center for Biomedical Imaging  New York New York USA"},{"name":"Center for Advanced Imaging Innovation and Research (CAI\u00b2R)  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne S.","family":"Rauh","sequence":"additional","affiliation":[{"name":"Department of Radiology, C.J. 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