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The ultrashort echo time magnetization transfer technique (UTE\u2010MT) facilitates assessment of macromolecular changes in collagen\u2010 or myelin\u2010rich tissues in nerve roots.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To assess lumbar nerve root composition in LDH using UTE\u2010MT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Type<\/jats:title>\n                    <jats:p>Prospective.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Population<\/jats:title>\n                    <jats:p>One hundred and seventy\u2010six participants (age range, 20\u201389; 72 females) with LDH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Field Strength\/Sequence<\/jats:title>\n                    <jats:p>3T\/UTE\u2010MT, Carr\u2010Purcell\u2010Meiboom\u2010Gill (CPMG).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Assessment<\/jats:title>\n                    <jats:p>\n                      UTE\u2010MT ratio (UTE\u2010MTR) and T\n                      <jats:sub>2<\/jats:sub>\n                      value in compressed nerve roots (determined on axial T\n                      <jats:sub>2<\/jats:sub>\n                      ) were evaluated by UTE\u2010MT and CPMG in LDH patients (L4\/5\u2010L5\/S1). Additionally, pain and functionality were evaluated using the visual analog scale (VAS) and Oswestry Disability Index (ODI).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Statistical Tests<\/jats:title>\n                    <jats:p>\n                      Linear regression and Bland\u2013Altman assessed UTE\u2010MT reproducibility. One\u2010way ANOVA assessed the statistical significance of UTE\u2010MTR and T\n                      <jats:sub>2<\/jats:sub>\n                      measures between compressed and intact nerve roots. ROC and DCA evaluated diagnostic performance and clinical value of UTE\u2010MTR and T\n                      <jats:sub>2<\/jats:sub>\n                      in discriminating between compressed and intact nerve roots. Linear regression correlated UTE\u2010MTR and T\n                      <jats:sub>2<\/jats:sub>\n                      with pain and functionality scores. The\n                      <jats:italic>p<\/jats:italic>\n                      value &lt;\u20090.05 was considered significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Significant increases in UTE\u2010MTR and decreases in T\n                      <jats:sub>2<\/jats:sub>\n                      values in compressed nerve roots compared to intact ones. High AUC values for UTE\u2010MTR (0.912 at L4\/5 and 0.900 at L5\/S1) highlighted its superior ability to distinguish between compressed and intact nerve roots, outperforming T\n                      <jats:sub>2<\/jats:sub>\n                      (AUCs of 0.840 and 0.790, respectively) in cohort discrimination. Strong significant positive correlations were found between UTE\u2010MTR and VAS (\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.63) and ODI (\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.62), while T\n                      <jats:sub>2<\/jats:sub>\n                      values showed moderate significant negative correlations with VAS (\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.32) and ODI (\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.32) for the measurement of the most severely compressed nerve roots (determined on axial T\n                      <jats:sub>2<\/jats:sub>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Conclusion<\/jats:title>\n                    <jats:p>UTE\u2010MT technique can detect macromolecular alterations in the compressed nerve roots of patients diagnosed with LDH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>1.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Technical Efficacy<\/jats:title>\n                    <jats:p>Stage 2.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jmri.70291","type":"journal-article","created":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T05:11:21Z","timestamp":1773292281000},"page":"251-261","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Ultrashort Echo Time Magnetization Transfer\n                    <scp>MR<\/scp>\n                    Imaging of Lumbar Nerve Roots in Patients With Disc Herniation"],"prefix":"10.1002","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1618-7140","authenticated-orcid":false,"given":"Jin","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Radiology Ruijin Hospital, Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"Department of Radiology The Fifth Affiliated Hospital of Sun Yat\u2010Sen University  Zhuhai Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxin","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Radiology The Fifth Affiliated Hospital of Sun Yat\u2010Sen University  Zhuhai Guangdong Province 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