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Ultrahigh\u2010field MRI may improve its detection and conspicuity.<\/jats:p>\n <\/jats:sec>\n \n Purpose<\/jats:title>\n \n To quantitatively and qualitatively compare the in\u00a0vivo appearance of the SoG at 3 versus 7\u2009T using matched high\u2010resolution T\n 2<\/jats:sub>\n \u2010weighted fast spin\u2010echo MRI.\n <\/jats:p>\n <\/jats:sec>\n \n Study Type<\/jats:title>\n Prospective.<\/jats:p>\n <\/jats:sec>\n \n Population<\/jats:title>\n A total of 12 subjects (6 female, 6 male; median age, 17\u2009years; range, 15\u201324\u2009years) with pediatric\u2010onset epilepsy.<\/jats:p>\n <\/jats:sec>\n \n Field Strength\/Sequence<\/jats:title>\n \n 3 and 7\u2009T MRI, T\n 2<\/jats:sub>\n \u2010weighted fast spin\u2010echo, acquired within 1\u2009month of each other.\n <\/jats:p>\n <\/jats:sec>\n \n Assessment<\/jats:title>\n Cortical line profiles per subject were extracted orthogonally to the calcarine sulcus in V1. Quantitative metrics included peak\u2010valley distance, \u0394\u2010signal (peak\u2010valley difference), and contrast ratio (CR). Two blinded neuroradiologists and a radiologist independently rated SoG conspicuity using a 5\u2010point Likert scale.<\/jats:p>\n <\/jats:sec>\n \n Statistical Tests<\/jats:title>\n \n McNemar's test compared detection rates; paired\n t<\/jats:italic>\n \u2010tests or Wilcoxon signed\u2010rank tests compared quantitative metrics; reader preferences were analyzed using Wilcoxon tests; inter\u2010reader agreement was assessed using weighted Cohen's\n \u03ba<\/jats:italic>\n . No multiple\u2010comparison correction was applied (\n \u03b1<\/jats:italic>\n \u2009=\u20090.05).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n SoG\u2010consistent valleys were detected in 31% of profiles at 3\u2009T and 65% at 7\u2009T, significantly. Peak\u2010valley distance remained stable across field strengths (0.45\u2009\u00b1\u20090.06 depth units;\n p<\/jats:italic>\n \u2009=\u20090.37). Mean \u0394\u2010signal (33.5 vs. 36.1;\n p<\/jats:italic>\n \u2009=\u20090.81) and contrast ratio (0.013 vs. 0.000;\n p<\/jats:italic>\n \u2009=\u20090.54) did not differ significantly. Both readers demonstrated a strong preference for 7\u2009T images (pseudo\u2010median +1 to +1.5; significant), with fair inter\u2010reader agreement (\n \u03ba<\/jats:italic>\n \u2009=\u20090.36).\n <\/jats:p>\n <\/jats:sec>\n \n Data Conclusion<\/jats:title>\n The SoG can be visualized in\u00a0vivo at both 3 and 7\u2009T, with higher detection frequency and greater subjective conspicuity at 7\u2009T. Quantitative laminar metrics remained stable across field strengths, suggesting that improved detectability at 7\u2009T likely reflects enhanced spatial definition rather than measurable changes in signal contrast.<\/jats:p>\n <\/jats:sec>\n \n Level of Evidence<\/jats:title>\n 2.<\/jats:p>\n <\/jats:sec>\n \n Technical Efficacy<\/jats:title>\n Stage 2.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/jmri.70312","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T04:56:53Z","timestamp":1774933013000},"page":"201-208","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of Myeloarchitectonic Feature Recognition of the Primary Visual Cortex at\n 7\u2009T<\/scp>\n Relative to\n 3\u2009T MRI<\/scp>"],"prefix":"10.1002","volume":"64","author":[{"given":"Sergio","family":"Valencia","sequence":"first","affiliation":[{"name":"Department of Radiology Massachusetts General Hospital Boston Massachusetts USA"},{"name":"Pediatric Imaging Research Center Massachusetts General Hospital Boston Massachusetts USA"},{"name":"Harvard Medical School Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emil","family":"Barkovich","sequence":"additional","affiliation":[{"name":"Department of Radiology Massachusetts General Hospital Boston Massachusetts USA"},{"name":"Pediatric Imaging Research Center Massachusetts General Hospital Boston Massachusetts USA"},{"name":"Harvard Medical School Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fedel","family":"Machado\u2010Rivas","sequence":"additional","affiliation":[{"name":"Department of Radiology Massachusetts General Hospital Boston Massachusetts USA"},{"name":"Pediatric Imaging Research Center Massachusetts General Hospital Boston Massachusetts USA"},{"name":"Harvard Medical School Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6373-1068","authenticated-orcid":false,"given":"Phillip L.","family":"Pearl","sequence":"additional","affiliation":[{"name":"Harvard Medical School Boston Massachusetts USA"},{"name":"Department of Neurology Boston Children\u2019s Hospital Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7659-3880","authenticated-orcid":false,"given":"Simon K.","family":"Warfield","sequence":"additional","affiliation":[{"name":"Harvard Medical School Boston Massachusetts USA"},{"name":"Department of Radiology Boston Children's Hospital Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2112-3205","authenticated-orcid":false,"given":"Onur","family":"Afacan","sequence":"additional","affiliation":[{"name":"Harvard Medical School Boston Massachusetts USA"},{"name":"Department of Radiology Boston Children's Hospital Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7169-4244","authenticated-orcid":false,"given":"Camilo","family":"Jaimes","sequence":"additional","affiliation":[{"name":"Department of Radiology Massachusetts General Hospital Boston Massachusetts USA"},{"name":"Pediatric Imaging Research Center Massachusetts General Hospital Boston Massachusetts USA"},{"name":"Harvard Medical School Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,30]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2017.09.037"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-neuro-071714-033936"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-012-0460-z"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2022.119617"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhae362"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLI.0000000000000015"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-014-3480-7"},{"key":"e_1_2_9_9_1","unstructured":"A.Stamm O.Afacan B.Scherrer J. 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