{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T04:57:17Z","timestamp":1781153837371,"version":"3.54.1"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T00:00:00Z","timestamp":1775088000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T00:00:00Z","timestamp":1775088000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001858","name":"VINNOVA","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2026,7]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Three\u2010dimensional (3D) MR elastography (MRE) derives viscoelastic parameters that may reflect inflammation, but their frequency dependence and the influence of steatosis on inflammation grading and fibrosis staging remain unclear.<\/jats:p>\n <\/jats:sec>\n \n Purpose<\/jats:title>\n To investigate 3D multifrequency MRE for assessing hepatic inflammation, fibrosis stage across frequencies, and the influence of steatosis.<\/jats:p>\n <\/jats:sec>\n \n Study Type<\/jats:title>\n Prospective.<\/jats:p>\n <\/jats:sec>\n \n Population<\/jats:title>\n Sixty\u2010four (40 men, median age: 58\u2009years) participants with chronic liver disease (CLD); 21 (8 men, median age: 28\u2009years) healthy volunteers.<\/jats:p>\n <\/jats:sec>\n \n Field Strength\/Sequence<\/jats:title>\n 3\u2010T; gradient\u2010echo sequence with mechanical vibrations at low (16.7 and 18\u2009Hz), medium (33.4 and 36\u2009Hz), and high (50.1 and 54\u2009Hz) frequencies.<\/jats:p>\n <\/jats:sec>\n \n Assessment<\/jats:title>\n In CLD participants, MRE\u2010derived viscoelastic parameters, shear stiffness, storage modulus, loss modulus, and damping ratio were compared with histologically assessed fibrosis, inflammation, and steatosis. MRE test\u2013retest repeatability over 10\u2009min was evaluated in healthy volunteers.<\/jats:p>\n <\/jats:sec>\n \n Statistical Tests<\/jats:title>\n \n Wilcoxon rank sum test, Spearman's correlation, multivariable regression analysis, and area under the receiver operating curve (AUROC). A\n p<\/jats:italic>\n value of <\u20090.05 was considered statistically significant.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Inflammation was significantly independently associated with damping ratio at medium frequency, which showed moderate performance for grading inflammation (AUROC\u2009=\u20090.76\u20130.83, sensitivity\u2009=\u20090.83\u20130.84, specificity\u2009=\u20090.70\u20130.79). Fibrosis staging using shear stiffness and moduli showed high diagnostic performance (AUROC\u2009=\u20090.82\u20130.95), with comparable accuracy between medium and high frequencies (\n p\u2009=<\/jats:italic>\n \u20090.327\u20130.896). Steatosis was not significantly correlated with MRE overall (\n p<\/jats:italic>\n \u2009=\u20090.212\u20130.459), but was significantly associated with 19% higher stiffness and 20% higher loss modulus at medium frequency in CLD participants without fibrosis or inflammation.\n <\/jats:p>\n <\/jats:sec>\n \n Data Conclusion<\/jats:title>\n Medium frequency 3D MRE demonstrated an independent association with inflammation while preserving accurate fibrosis assessment. Steatosis seemed not to confound MRE\u2010based evaluation.<\/jats:p>\n <\/jats:sec>\n \n Level of Evidence<\/jats:title>\n 1.<\/jats:p>\n <\/jats:sec>\n \n Technical Efficacy<\/jats:title>\n Stage 2.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/jmri.70319","type":"journal-article","created":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T09:51:52Z","timestamp":1775123512000},"page":"306-319","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Chronic Liver Disease: Assessing Inflammation and Fibrosis Using Three\u2010Dimensional\n MR<\/scp>\n Elastography With Same\u2010Day Biopsy in a Prospective Cohort"],"prefix":"10.1002","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5713-6385","authenticated-orcid":false,"given":"Shan","family":"Cai","sequence":"first","affiliation":[{"name":"Department of Health, Medicine and Caring Sciences Link\u00f6ping University Link\u00f6ping Sweden"},{"name":"Center for 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