{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T05:07:33Z","timestamp":1783832853794,"version":"3.55.0"},"reference-count":42,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:00:00Z","timestamp":1776211200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:00:00Z","timestamp":1776211200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["RS\u20102026\u201025468417"],"award-info":[{"award-number":["RS\u20102026\u201025468417"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["RS\u20102023\u201000237618"],"award-info":[{"award-number":["RS\u20102023\u201000237618"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","award":["RS\u20102023\u201000266288"],"award-info":[{"award-number":["RS\u20102023\u201000266288"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Susceptibility map\u2010weighted imaging (SMwI) provides high accuracy for early Parkinson's disease (ePD) by enhancing nigral hyperintensity. However, standard SMwI requires dedicated acquisition; reconstruction from routinely acquired sequences may offer a practical alternative.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To compare the diagnostic performance of standard SMwI with SWI\u2010 and neuromelanin (NM)\u2010driven SMwI for differentiating ePD from disease controls (DC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Type<\/jats:title>\n                    <jats:p>Retrospective.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Subjects<\/jats:title>\n                    <jats:p>One hundred and eighty\u2010seven drug\u2010na\u00efve ePD (age: 67.5\u2009\u00b1\u20099.4\u2009years, 102 male) and 43\u2009DC (age: 67.1\u2009\u00b1\u20099.2\u2009years, 12 male).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Field Strength\/Sequence<\/jats:title>\n                    <jats:p>3\u2009T, multi\u2010echo gradient\u2010echo (GRE) for standard SMwI; GRE\u2010based NM imaging: multi\u2010echo GRE for SWI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Assessment<\/jats:title>\n                    <jats:p>Nigral hyperintensity was assessed by three neuroradiologists (4\u2010, 2\u2010, and 1\u2010year experience). Diagnostic performance was evaluated using clinical diagnosis for all subjects and PET for 106 subjects (98 ePD, 8\u2009DC). PET\u2010based assessment included side\u2010based analyses accounting for PET laterality and patient\u2010based analyses regardless of direction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Statistical Tests<\/jats:title>\n                    <jats:p>\n                      Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), accuracy and area under the curve (AUC) were assessed using clinical diagnosis as reference; sensitivity, specificity, and accuracy using PET. Significance was set at\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Using clinical diagnosis as reference, standard SMwI showed highest diagnostic performance (sensitivity 0.856; specificity 1.000; PPV 1.000; AUC 0.928). SWI\u2010driven SMwI maintained similar sensitivity (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.355) but showed significantly reduced specificity, PPV, accuracy, AUC. In the PET subgroup, side\u2010 and patient\u2010based analyses showed no differences in sensitivity (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.261,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.670), specificity (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20091.000,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20091.000) and accuracy (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.268,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.695) between standard and SWI\u2010driven SMwI.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Conclusion<\/jats:title>\n                    <jats:p>SWI\u2010driven SMwI approached the diagnostic performance of standard SMwI with PET reference but showed inferior performance with clinical diagnosis, suggesting a fallback option when dedicated SMwI is unavailable.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Evidence Level<\/jats:title>\n                    <jats:p>3.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Technical Efficacy<\/jats:title>\n                    <jats:p>Stage 1.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jmri.70332","type":"journal-article","created":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T05:00:26Z","timestamp":1776315626000},"page":"404-412","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Comparison of Diagnostic Performance Between Standard Susceptibility Map\u2010Weighted Imaging and Susceptibility Map\u2010Weighted Imaging Reconstructed From Clinical\n  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