{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T05:07:34Z","timestamp":1783832854444,"version":"3.55.0"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T00:00:00Z","timestamp":1776384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T00:00:00Z","timestamp":1776384000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82471944"],"award-info":[{"award-number":["82471944"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009330","name":"Medical Science and Technology Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["A2024578"],"award-info":[{"award-number":["A2024578"]}],"id":[{"id":"10.13039\/501100009330","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Accurate imaging assessment of hepatocellular carcinoma (HCC) after stereotactic body radiotherapy (SBRT) remains challenging. Although LI\u2010RADS CT\/MRI Radiation Treatment Response Assessment (TRA v2024) was developed for this purpose, its prognostic value for survival stratification after SBRT remains to be validated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To compare the prognostic performance of mid\u2010term (3\u20136\u2009months) and late\u2010term (9\u201312\u2009months) MRI\u2010based treatment response assessed using modified RECIST (mRECIST), LI\u2010RADS TRA v2017, and LI\u2010RADS Radiation TRA v2024 in patients with HCC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Type<\/jats:title>\n                    <jats:p>Retrospective cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Population<\/jats:title>\n                    <jats:p>125 patients with HCC underwent SBRT (111 males; mean age, 56.4\u2009\u00b1\u200910.8\u2009years).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Field Strength\/Sequence<\/jats:title>\n                    <jats:p>3.0\u2009T; axial fat\u2010suppressed fast spin\u2010echo T2\u2010weighted imaging, diffusion\u2010weighted imaging, pre\u2010contrast gradient recalled echo T1\u2010weighted imaging, and contrast\u2010enhanced late arterial phase, portal venous phase, and delayed\/transitional phase.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Assessment<\/jats:title>\n                    <jats:p>Tumor response was independently evaluated by three radiologists using three treatment assessment methods. Ancillary features (AFs) were additionally recorded to assess their incremental prognostic value. Overall survival (OS) and progression\u2010free survival (PFS) were analyzed according to response categories.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Statistical Tests<\/jats:title>\n                    <jats:p>\n                      Kolmogorov\u2013Smirnov test, Intraclass correlation coefficients, Cohen's \u03ba, Variance inflation factor analysis, Kaplan\u2013Meier method, Log\u2010rank tests with Bonferroni correction, Univariate and multivariable Cox regression analyses. Statistical significance was defined as\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At mid\u2010term follow\u2010up, LI\u2010RADS Radiation TRA v2024 showed greater discrimination for PFS than mRECIST and LI\u2010RADS TRA v2017, with no OS difference (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.999). Across all three criteria, late\u2010term response assessment yielded better prognostic stratification for PFS and OS than did mid\u2010term evaluation. At the late\u2010term follow\u2010up, LI\u2010RADS Radiation TRA v2024 was strongly associated with OS (HR\u2009=\u200915.80, 95% CI: 3.34\u201375.00) and PFS (HR\u2009=\u20096.31, 95% CI: 2.68\u201314.90). Adding AFs provided no further prognostic improvement.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Conclusion<\/jats:title>\n                    <jats:p>LI\u2010RADS Radiation TRA v2024 demonstrates strong prognostic stratification after SBRT, particularly at late\u2010term MRI evaluation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Evidence Level<\/jats:title>\n                    <jats:p>3.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Technical Efficacy<\/jats:title>\n                    <jats:p>Stage 2.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jmri.70334","type":"journal-article","created":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T02:11:40Z","timestamp":1776478300000},"page":"454-465","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Prognostic Value of\n                    <scp>MRI<\/scp>\n                    \u2010Based Treatment Response Assessment Criteria in Hepatocellular Carcinoma After Stereotactic Body Radiotherapy: A Comparative Analysis of\n                    <scp>mRECIST<\/scp>\n                    ,\n                    <scp>LI<\/scp>\n                    \u2010\n                    <scp>RADS TRA<\/scp>\n                    Version 2017, and\n                    <scp>LI<\/scp>\n                    \u2010\n                    <scp>RADS<\/scp>\n                    Radiation\n                    <scp>TRA<\/scp>\n                    Version 2024"],"prefix":"10.1002","volume":"64","author":[{"given":"Fan","family":"Zhou","sequence":"first","affiliation":[{"name":"Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer Sun Yat\u2010Sen University Cancer Center  Guangzhou P. 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