{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T05:07:27Z","timestamp":1783832847897,"version":"3.55.0"},"reference-count":45,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T00:00:00Z","timestamp":1777075200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T00:00:00Z","timestamp":1777075200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003246","name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["17986"],"award-info":[{"award-number":["17986"]}],"id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2026,8]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n \n MR Spin TomogrAphy in Time\u2010domain (MR\u2010STAT) enables accelerated multiparametric relaxometry (T\n 1<\/jats:sub>\n \/T\n 2<\/jats:sub>\n ). Previous relaxometry studies predominantly compared Parkinson's disease patients with healthy controls (HC). The potential of relaxometry to distinguish neurodegenerative from non\u2010neurodegenerative parkinsonism in clinically uncertain parkinsonian syndrome (CUPS) patients is unclear.\n <\/jats:p>\n <\/jats:sec>\n \n Purpose<\/jats:title>\n \n To investigate T\n 1<\/jats:sub>\n \u2010\/T\n 2<\/jats:sub>\n \u2010differences between neurodegenerative and non\u2010neurodegenerative parkinsonism in CUPS patients.\n <\/jats:p>\n <\/jats:sec>\n \n Study Type<\/jats:title>\n Prospective cross\u2010sectional study.<\/jats:p>\n <\/jats:sec>\n \n Population<\/jats:title>\n 52 patients with neurodegenerative and 57 patients with non\u2010neurodegenerative parkinsonism, diagnosed via dopamine transporter single photon emission computed tomography (DAT SPECT) and neurologist review, and 10 HC.<\/jats:p>\n <\/jats:sec>\n \n Fieldstrength\/Sequence<\/jats:title>\n MP\u2010RAGE (magnetization\u2010prepared rapid acquisition with gradient\u2010echoes) and MR\u2010STAT, a 2D Cartesian\u2010encoded gradient\u2010spoiled gradient\u2010echo sequence with time\u2010varying flip\u2010angle preceded by a non\u2010selective inversion pulse, at 3T.<\/jats:p>\n <\/jats:sec>\n \n Assessment<\/jats:title>\n \n Repeatability of T\n 1<\/jats:sub>\n \u2010\/T\n 2<\/jats:sub>\n \u2010values was evaluated for cortical gray matter\/cerebral white matter\/thalamus\/putamen\/caudate nucleus\/globus pallidus (GP) in HC. T\n 1<\/jats:sub>\n \u2010\n \/<\/jats:sub>\n T\n 2<\/jats:sub>\n \u2010values of the parkinsonism groups were compared in the same regions per most\/less affected hemisphere (MAH\/LAH), determined by the putaminal uptake ratio on DAT SPECT.\n <\/jats:p>\n <\/jats:sec>\n \n Statistical Tests<\/jats:title>\n \n Regional coefficients of variation (CoV) were computed to assess the repeatability of T\n 1<\/jats:sub>\n \u2010\/T\n 2<\/jats:sub>\n \u2010values in HC. T\u2010tests (\n \u03b1<\/jats:italic>\n \u2009=\u20090.05) were used to compare T\n 1<\/jats:sub>\n \u2212\/T\n 2<\/jats:sub>\n \u2010values between parkinsonism groups, and Cohen's D values were computed with bootstrapping to measure effect sizes with 95% confidence intervals (95% CI).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n CoVs ranged from 0.5% to 1.7% (T\n 1<\/jats:sub>\n ) to 1.5% to 2.7% (T\n 2<\/jats:sub>\n ). In the MAH, significant T\n 1<\/jats:sub>\n \u2010differences were found in the thalamus (Cohen's D\u2009=\u20090.635, 95% CI\u2009=\u2009[0.251, 1.016]); GP (Cohen's D\u2009=\u20090.508, 95% CI\u2009=\u2009[0.129, 0.887]); internal GP (Cohen's D\u2009=\u20090.603, 95% CI\u2009=\u2009[0.220, 0.983]); external GP (Cohen's D\u2009=\u20090.411, 95% CI\u2009=\u2009[0.033, 0.787]); and centromedial putamen (Cohen's D\u2009=\u20090.447, 95% CI\u2009=\u2009[0.069, 0.824]). In the LAH, significant T\n 1<\/jats:sub>\n \u2010differences were found in the thalamus (Cohen's D\u2009=\u20090.476, 95% CI\u2009=\u2009[0.097, 0.853]); GP (Cohen's D\u2009=\u20090.415, 95% CI\u2009=\u2009[0.037, 0.791]); anteromedial putamen (Cohen's D\u2009=\u20090.388, 95% CI\u2009=\u2009[0.011, 0.764]); and external GP (Cohen's D\u2009=\u20090.416, 95% CI\u2009=\u2009[0.038, 0.792]). T\n 2<\/jats:sub>\n \u2010differences were non\u2010significant.\n <\/jats:p>\n <\/jats:sec>\n \n Data Conclusion<\/jats:title>\n MR\u2010STAT showed high repeatability and showed potential to differentiate neurodegenerative from non\u2010neurodegenerative parkinsonism in CUPS patients.<\/jats:p>\n <\/jats:sec>\n \n Evidence Level<\/jats:title>\n 1.<\/jats:p>\n <\/jats:sec>\n \n Technical Efficacy<\/jats:title>\n 1.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/jmri.70349","type":"journal-article","created":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T19:14:12Z","timestamp":1777144452000},"page":"429-439","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Mapping Neurodegenerative Changes in Clinically Uncertain Parkinsonian Syndrome Patients Using Fast\n MR<\/scp>\n Spin\n TomogrAphy<\/scp>\n in Time\u2010Domain (\n MR<\/scp>\n \u2010\n STAT<\/scp>\n ) Relaxometry at 3T"],"prefix":"10.1002","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-4058-4928","authenticated-orcid":false,"given":"Martin B.","family":"Schilder","sequence":"first","affiliation":[{"name":"Computational Imaging Group for MRI Therapy & Diagnostics, Department of Radiotherapy University Medical Center Utrecht Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0017-1160","authenticated-orcid":false,"given":"Elon D.","family":"Wallert","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine, Amsterdam UMC University of Amsterdam Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4612-5509","authenticated-orcid":false,"given":"Stefano","family":"Mandija","sequence":"additional","affiliation":[{"name":"Computational Imaging Group for MRI Therapy & Diagnostics, Department of Radiotherapy University Medical Center Utrecht Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar","family":"van der Heide","sequence":"additional","affiliation":[{"name":"Computational Imaging Group for MRI Therapy & Diagnostics, Department of Radiotherapy University Medical Center Utrecht Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyan","family":"Liu","sequence":"additional","affiliation":[{"name":"Computational Imaging Group for MRI Therapy & Diagnostics, Department of Radiotherapy University Medical Center Utrecht Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5673-915X","authenticated-orcid":false,"given":"Miha","family":"Fuderer","sequence":"additional","affiliation":[{"name":"Computational Imaging Group for MRI Therapy & Diagnostics, Department of Radiotherapy University Medical Center Utrecht Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3235-3970","authenticated-orcid":false,"given":"Edwin","family":"Versteeg","sequence":"additional","affiliation":[{"name":"Computational Imaging Group for MRI Therapy & Diagnostics, Department of Radiotherapy University Medical Center Utrecht Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6378-7638","authenticated-orcid":false,"given":"Jan","family":"Booij","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine, Amsterdam UMC University of Amsterdam Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5267-0784","authenticated-orcid":false,"given":"Rob M. 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