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Behavior data were based on Wechsler Intelligence Scale for children\u2010Fourth edition while transcriptional profiles were from the Allen Human Brain Atlas.<\/jats:p>\n <\/jats:sec>\n \n Statistical Tests<\/jats:title>\n \n Independent\n T<\/jats:italic>\n \u2010tests, chi\u2010square tests, general linear models, permutation testing, multivariable linear regression, mediation analyses, partial least squares regression, spatial permutation tests (Spin test), Gene Ontology enrichment analysis and cell\u2010type analysis. FDR\u2010corrected\n p<\/jats:italic>\n \u2009<\u20090.05 and\n p<\/jats:italic>\n \n spin<\/jats:italic>\n <\/jats:sub>\n \u2009<\u20090.05 were considered significant.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Dp140\u2212 subgroup had lower working memory index (WMI) than Dp140+ DMD (81.63 \u00b1 15.48 vs. 90.78 \u00b1 15.31;\n p<\/jats:italic>\n \u2009=\u20090.01, Cohen's\n d<\/jats:italic>\n \u2009=\u20090.179). Dp140\u2212 DMD showed reduced cortical similarity in bilateral lateral prefrontal cortex and parietal cortex regions, increased modular segregation (Hedge's\n g<\/jats:italic>\n \u2009=\u2009\u22120.298, 95% CI [\u22120.408, \u22120.187]), and more hubs loss within frontal parietal network (FPN). The indirect effect of Dp140 genotype on WMI through mean FPN cortical similarity was significant (\n \u03b2<\/jats:italic>\n \u2009=\u2009\u22120.121,\n p<\/jats:italic>\n \u2009=\u20090.03, 95% CI [\u22120.282, \u22120.001]). The Dp140\u2010specific MSN changes were spatially associated with transcriptional profile, which are enriched in neuronal projection development pathways of excitatory neurons (\n p<\/jats:italic>\n \n spin<\/jats:italic>\n <\/jats:sub>\n \u2009<\u20090.05).\n <\/jats:p>\n <\/jats:sec>\n \n Data Conclusion<\/jats:title>\n By linking genotype, neuroimaging, and transcriptional data, these findings offer further insight into mechanisms possibly involved in working memory deficits among Dp140\u2212 DMD.<\/jats:p>\n <\/jats:sec>\n \n Evidence Level<\/jats:title>\n 2.<\/jats:p>\n <\/jats:sec>\n \n Technical Efficacy<\/jats:title>\n Stage 2.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/jmri.70354","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T11:25:52Z","timestamp":1778671552000},"page":"768-784","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Relationship Between Dp140 Genotype and Cortical Similarity Network Phenotype in Duchenne Muscular Dystrophy: Preliminary\n T1<\/scp>\n Weighted Study"],"prefix":"10.1002","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-0337-2526","authenticated-orcid":false,"given":"Suming","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Radiology, Key Laboratory of Obstetric & Gynecologic and Pediatric Disease and Birth Defects of Ministry of Education, West China Second University Hospital Sichuan University Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5056-3878","authenticated-orcid":false,"given":"Xiaoyu","family":"Niu","sequence":"additional","affiliation":[{"name":"Department of Radiology, Key Laboratory of Obstetric & Gynecologic and Pediatric Disease and Birth Defects of Ministry of Education, West China Second University Hospital Sichuan University Chengdu Sichuan 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