{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T20:29:17Z","timestamp":1786566557980,"version":"build-2736575974"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:00:00Z","timestamp":1779321600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:00:00Z","timestamp":1779321600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2026,9]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Traditional methods for evaluating split renal function, including contrast\u2010enhanced CT and radionuclide imaging, have limitations related to ionizing radiation or potentially nephrotoxic contrast agents.<\/jats:p>\n <\/jats:sec>\n \n Purpose<\/jats:title>\n To investigate the value of renal blood flow (RBF)\u2010weighted estimated glomerular filtration rate (eGFR) derived from arterial spin labeling (ASL)\u2010MRI in predicting split renal function in patients with suspected renal artery stenosis (RAS).<\/jats:p>\n <\/jats:sec>\n \n Study Type<\/jats:title>\n Retrospective.<\/jats:p>\n <\/jats:sec>\n \n Population<\/jats:title>\n Fifty\u2010three consecutive patients (21 females; mean age, 61.28\u2009\u00b1\u200913.50\u2009years) with suspected RAS and renal insufficiency underwent renal ASL\u2010MRI.<\/jats:p>\n <\/jats:sec>\n \n Field Strength\/Sequence<\/jats:title>\n \n 1.\n 5T<\/jats:styled-content>\n ;\n 3D<\/jats:styled-content>\n pseudo\u2010continuous\n ASL<\/jats:styled-content>\n technique.\n <\/jats:p>\n <\/jats:sec>\n \n Assessment<\/jats:title>\n RBF and regions of interest (ROI) areas of the renal cortex and entire kidney were measured on oblique coronal ASL\u2010MRI perfusion maps. The RBF\u2010weighted eGFR (RBFw eGFR) for each kidney was derived by normalizing the RBF\u2010area product to the bilateral total eGFR. The radionuclide GFR (rGFR) obtained from renal dynamic radionuclide imaging was used as the reference standard.<\/jats:p>\n <\/jats:sec>\n \n Statistical Test<\/jats:title>\n \n Paired\n t<\/jats:italic>\n \u2010tests, one\u2010way repeated\u2010measures ANOVA, Bonferroni test, Pearson's correlation analysis, and receiver operating characteristic (ROC) curves were used. Statistical significance was set at\n p<\/jats:italic>\n \u2009=\u20090.05.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n The cortical and entire RBFw eGFR showed strong significant correlations with rGFR (r: 0.799 vs. 0.800). The cortical and entire RBFw eGFR had high diagnostic efficiency for differentiating severe, moderate, and mild renal insufficiency (AUC: 0.934 vs. 0.936, 0.927 vs. 0.928, and 0.873 vs. 0.865).<\/jats:p>\n <\/jats:sec>\n \n Data Conclusions<\/jats:title>\n The RBFw eGFR derived from ASL\u2010MRI demonstrated a significant correlation with rGFR and high diagnostic performance for differentiating split renal dysfunction grades, suggesting potential for split renal function assessment in patients with RAS.<\/jats:p>\n <\/jats:sec>\n \n Evidence Level<\/jats:title>\n 3 (Nonconsecutive cohort studies, usually retrospective with an imperfectly applied reference standard).<\/jats:p>\n <\/jats:sec>\n \n Technical Efficacy<\/jats:title>\n 2 (diagnostic accuracy\/clinical efficacy).<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/jmri.70365","type":"journal-article","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T10:15:27Z","timestamp":1779358527000},"page":"712-721","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Study on Predicting Split Renal Function Using Renal Blood Flow Weighted Estimated Glomerular Filtration Rate From Arterial Spin Labeling\n MRI<\/scp>"],"prefix":"10.1002","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3528-3074","authenticated-orcid":false,"given":"Zhiyong","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Radiology Peking University First Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology Peking University First Hospital Beijing China"},{"name":"Institute of Cardiovascular Disease, Peking University First Hospital Beijing China"},{"name":"Hypertension Precision Diagnosis and Treatment Research Center, Peking University First Hospital Beijing China"},{"name":"Information Center, Peking University First Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3105-2906","authenticated-orcid":false,"given":"Rui","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology Peking University First Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiology Peking University First Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4314-4667","authenticated-orcid":false,"given":"Jinxia","family":"Zhu","sequence":"additional","affiliation":[{"name":"MR Research Collaboration, Siemens Healthineers Ltd. Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernd","family":"Kuehn","sequence":"additional","affiliation":[{"name":"Research & Clinical Translation, Magnetic Resonance, Siemens Healthineers AG Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8808-8021","authenticated-orcid":false,"given":"Jianxing","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Radiology Peking University First Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianping","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology Peking University First Hospital Beijing China"},{"name":"Institute of Cardiovascular Disease, Peking University First Hospital Beijing China"},{"name":"Hypertension Precision Diagnosis and Treatment Research Center, Peking University First Hospital Beijing China"},{"name":"State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,21]]},"reference":[{"issue":"9","key":"e_1_2_8_2_1","article-title":"A Literature Review of Renal Artery Stenosis: Presentation, Diagnosis, and Management Options in Secondary Hypertension","volume":"17","author":"Bendagiri Matam M.","year":"2025","journal-title":"Cureus"},{"issue":"1","key":"e_1_2_8_3_1","first-page":"1","article-title":"Management of Atherosclerotic Renal\u2010Artery Stenosis in 2016","volume":"13","author":"Fournier T.","year":"2017","journal-title":"N\u00e9phrologie & Th\u00e9rapeutique"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajhp\/zxaf044"},{"issue":"5","key":"e_1_2_8_5_1","article-title":"The Role of Arterial Spin Labeling Functional MRI in Assessing Perfusion Impairment of Renal Allografts: A Systematic Review","volume":"14","author":"Chhabra 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