{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T20:29:22Z","timestamp":1786566562980,"version":"build-2736575974"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:00:00Z","timestamp":1781136000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:00:00Z","timestamp":1781136000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82202248"],"award-info":[{"award-number":["82202248"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2026,9]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Hypertrophic cardiomyopathy (HCM) is a leading cause of sudden cardiac death (SCD). Early identification of high\u2010risk patients is important for guiding preventive measures.<\/jats:p>\n <\/jats:sec>\n \n Purpose<\/jats:title>\n To validate left ventricular (LV) myocardial trabecular complexity using fractal dimension (FD) for SCD prediction in a larger cohort and investigate its relationship with sarcomere variants.<\/jats:p>\n <\/jats:sec>\n \n Study Type<\/jats:title>\n Prospective.<\/jats:p>\n <\/jats:sec>\n \n Population<\/jats:title>\n 835\u2009HCM patients (506 men; 50.7\u2009\u00b1\u200914.4\u2009years).<\/jats:p>\n <\/jats:sec>\n \n Field Strength\/Sequence<\/jats:title>\n Steady\u2010state free precession (SSFP) cine sequence at 3\u2009T.<\/jats:p>\n <\/jats:sec>\n \n Assessment<\/jats:title>\n Two cardiologists, blinded to clinical outcomes, independently analyzed assigned cardiac MRI cases. Biventricular function, late gadolinium enhancement, and LV FD were measured with fracAnalyse. The endpoint was SCD or aborted SCD. Sarcomere variants were classified by the American College of Medical Genetics and Genomics criteria, and their associations with FD were assessed.<\/jats:p>\n <\/jats:sec>\n \n Statistical Tests<\/jats:title>\n \n Cox regression assessed associations with SCD. Kaplan\u2013Meier analysis and log\u2010rank test were used to compare SCD incidence. Harrell's C\u2010index assessed model discrimination. Welch's\n t<\/jats:italic>\n \u2010test compared FD between variant groups. Two\u2010sided\n p<\/jats:italic>\n \u2009<\u20090.05 indicated significance.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Global FD (hazard ratio [HR] per 0.01 increase, 1.07, 95% CI: 1.01\u20131.15) and maximal apical FD (HR, 1.08, 95% CI: 1.02\u20131.14) independently predicted SCD after adjustment for European Society of Cardiology and American Heart Association risk predictors. High global FD (\u2265\u20091.256) or maximal apical FD (\u2265\u20091.352) improved model discrimination (C\u2010index: 0.779\u20130.803, 0.77\u20130.791).\n MYBPC3<\/jats:italic>\n carriers had significantly higher maximal apical FD (1.35\u2009\u00b1\u20090.05 vs. 1.33\u2009\u00b1\u20090.07), maximal basal FD (1.35\u2009\u00b1\u20090.05 vs. 1.32\u2009\u00b1\u20090.06), and mean basal FD (1.28\u2009\u00b1\u20090.06 vs. 1.25\u2009\u00b1\u20090.07) than other sarcomere variant carriers.\n <\/jats:p>\n <\/jats:sec>\n \n Data Conclusion<\/jats:title>\n \n LV global and apical FDs provide independent and incremental prognostic value for predicting SCD.\n MYBPC3<\/jats:italic>\n variant carriers exhibited elevated FD values, linking trabecular complexity with genetic variants in HCM.\n <\/jats:p>\n <\/jats:sec>\n \n Evidence Level<\/jats:title>\n 2.<\/jats:p>\n <\/jats:sec>\n \n Technical Efficacy<\/jats:title>\n Stage 3.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/jmri.70380","type":"journal-article","created":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T02:45:15Z","timestamp":1781232315000},"page":"847-859","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Prognostic Value of\n MRI<\/scp>\n \u2010Based Left Ventricular Trabecular Complexity for Sudden Cardiac Death in Hypertrophic Cardiomyopathy"],"prefix":"10.1002","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-8192-5801","authenticated-orcid":false,"given":"Jinquan","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Cardiology, West China Hospital Sichuan University Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengdi","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, West China Hospital Sichuan University Chengdu Sichuan 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