{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T05:03:05Z","timestamp":1789534985746,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:00:00Z","timestamp":1781136000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:00:00Z","timestamp":1781136000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Antiretroviral therapy has transformed HIV into a chronic condition, yet cardiac injury remains a major issue.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To assess the ability of cardiac MR imaging markers to predict cardiac injury and disease progression in HIV\u2010infected individuals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Type<\/jats:title>\n                    <jats:p>Prospective.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Subjects<\/jats:title>\n                    <jats:p>\n                      Eighty\u2010three HIV\u2010infected participants (short\u2010duration infection &lt;\u20095\u2009years,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200943; long\u2010duration \u2265\u20095\u2009years,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200940) and 34 matched HIV\u2010negative controls.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Field Strength\/Sequence<\/jats:title>\n                    <jats:p>1.5\u2009T; SSFP cine and MOLLI sequences.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Assessment<\/jats:title>\n                    <jats:p>Left ventricular (LV) end diastolic volume indexed to body surface area (LVEDVi), ejection fraction (LVEF), mass (LVM), myocardial mass\u2010to\u2010volume ratio (MVR), and global strains were determined from SSFP cine data. Extracellular volume (ECV) and myocardial extracellular matrix volume index (ECMVi) were determined from pre\u2010 and post\u2010contrast myocardial T1 values.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Statistical Tests<\/jats:title>\n                    <jats:p>\n                      ANOVA, Kruskal\u2013Wallis, post hoc tests, correlation, and multivariable logistic regression;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05 indicated statistical significance.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Both the HIV groups showed significantly elevated ECV (short: median 28.02 [25.40\u201331.86]%; long: median 28.18 [24.40\u201337.99]% vs. 25.07%\u2009\u00b1\u20095.61%) and myocardial native T1 (1863.35\u2009\u00b1\u2009300.29\u2009ms; median 1963.00 [1807.00, 2072.25]\u2009ms vs. median 1734 [1309.75\u20131981.50]\u2009ms) compared to controls. The long\u2010duration group exhibited significantly higher ECMVi (14.73\u2009\u00b1\u20094.59\u2009mL\/m\n                      <jats:sup>2<\/jats:sup>\n                      vs. controls: 10.52\u2009\u00b1\u20092.82\u2009mL\/m\n                      <jats:sup>2<\/jats:sup>\n                      and short: 12.32\u2009\u00b1\u20092.83\u2009mL\/m\n                      <jats:sup>2<\/jats:sup>\n                      ) and MVR (0.78\u2009\u00b1\u20090.16 vs. 0.61\u2009\u00b1\u20090.11\u2009g\/mL and median 0.63 [0.55\u20130.69]\u2009g\/mL), significantly reduced LVEDVi (65.44\u2009\u00b1\u200913.21 vs. 73.42\u2009\u00b1\u200910.99 and 72.08\u2009\u00b1\u200910.62\u2009mL\/m\n                      <jats:sup>2<\/jats:sup>\n                      ) and significantly diminished global radial strain (29.82%\u2009\u00b1\u20096.28% vs. controls: 36.18%\u2009\u00b1\u20096.39% and short: median 33.16 [28.44\u201337.52]%).HIV duration correlated positively with ECMVi and MVR (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.277 and 0.474, respectively), and significantly negatively correlated with global radial strain (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u2009\u22120.244). Two robust MRI models were validated: ECV\/native T1\/fasting blood glucose (FBG) for early HIV (AUC\u2009=\u20090.852) and LVEDVi\/ECMVi\/FBG for duration stratification (AUC\u2009=\u20090.844), with stable performance through bootstrapping and calibration.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>ECV, myocardial native T1, and FBG can predict short\u2010duration HIV infection, while a multimodal model (LVEDVi, ECMVi, and FBG)stratifies duration. However, prospective validation is necessary.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Evidence Level<\/jats:title>\n                    <jats:p>2.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Technical Efficacy<\/jats:title>\n                    <jats:p>Stage 3.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jmri.70395","type":"journal-article","created":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T02:41:01Z","timestamp":1781232061000},"page":"1037-1049","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Association Between\n                    <scp>HIV<\/scp>\n                    Infection Duration and Left Ventricular Concentric Remodeling and Myocardial Fibrosis: A Cross\u2010Sectional Study Using Cardiac\n                    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