{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T16:08:48Z","timestamp":1789574928955,"version":"build-2803163510"},"reference-count":49,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC2414206"],"award-info":[{"award-number":["2023YFC2414206"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371903"],"award-info":[{"award-number":["82371903"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82502289"],"award-info":[{"award-number":["82502289"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2024A1515012087"],"award-info":[{"award-number":["2024A1515012087"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2026,10]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Patients with multivessel disease (MVD) after acute myocardial infarction (AMI) have worse outcomes than those with single\u2010vessel disease (SVD), but whether MVD is associated with diffuse myocardial injury beyond the infarct zone (IZ) remains unclear.<\/jats:p>\n <\/jats:sec>\n \n Purpose<\/jats:title>\n To characterize infarct\u2010related and remote myocardial tissue properties using cardiac MRI in patients with MVD compared with SVD after AMI, and to explore differences according to revascularization completeness.<\/jats:p>\n <\/jats:sec>\n \n Study Type<\/jats:title>\n Retrospective.<\/jats:p>\n <\/jats:sec>\n \n Population<\/jats:title>\n Two hundred and twenty\u2010four patients with AMI who underwent MRI within 31\u201390\u2009days after percutaneous coronary intervention (90 SVD, 42 MVD with complete revascularization [CR], and 92 MVD with incomplete revascularization [IR]).<\/jats:p>\n <\/jats:sec>\n \n Field Strength\/Sequences<\/jats:title>\n 3.0\u2009T; balanced steady\u2010state free precession cine, phase\u2010sensitive inversion recovery late gadolinium enhancement (LGE), modified Look\u2010Locker (pre\u2010 and post\u2010contrast T1\u2010mapping), and gradient and spin echo (T2\u2010mapping) sequences.<\/jats:p>\n <\/jats:sec>\n \n Assessment<\/jats:title>\n Left ventricular volumes and function (cine), infarct size (LGE), and myocardial tissue parameters (native T1 and extracellular volume [ECV], and T2) were quantified in IZ, peri\u2010infarct zone (PIZ), and remote zone (RZ) using standardized methods.<\/jats:p>\n <\/jats:sec>\n \n Statistical Tests<\/jats:title>\n \n Group comparisons used Student's\n t<\/jats:italic>\n \u2010test or Mann\u2013Whitney\n U<\/jats:italic>\n test for continuous variables and\n \u03c7<\/jats:italic>\n 2<\/jats:sup>\n or Fisher exact test for categorical variables. Adjusted comparisons of myocardial tissue parameters between coronary disease groups were performed using multivariable logistic regression models including relevant clinical covariates and infarct size. A\n p<\/jats:italic>\n value <\u20090.05 was considered significant.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Compared with SVD, MVD showed larger infarct size (\n p<\/jats:italic>\n \u2009<\u20090.001), and higher native T1, ECV, and T2 values in PIZ (\n p<\/jats:italic>\n \u2009=\u20090.034, 0.004, 0.005) and RZ (\n p<\/jats:italic>\n \u2009=\u20090.041, <\u20090.001, <\u20090.001). After adjustment for clinical covariates (age, diabetes, hyperlipidemia, BMI) and infarct size, these differences in RZ remained significant. Among patients with MVD, infarct size and ventricular function did not differ between CR and IR groups (\n p<\/jats:italic>\n \u2009=\u20090.661, 0.494, 0.857). However, MVD\u2010IR was associated with significantly higher ECV\u2010PIZ (\n p<\/jats:italic>\n \u2009=\u20090.023), ECV\u2010RZ (\n p<\/jats:italic>\n \u2009=\u20090.025) and T2\u2010RZ (\n p<\/jats:italic>\n \u2009=\u20090.003).\n <\/jats:p>\n <\/jats:sec>\n \n Data Conclusions<\/jats:title>\n In AMI, MVD was associated with diffuse myocardial injury extending beyond the IZ. Differences related to revascularization completeness predominantly involved non\u2010infarct myocardium.<\/jats:p>\n <\/jats:sec>\n \n Level of Evidence<\/jats:title>\n 3.<\/jats:p>\n <\/jats:sec>\n \n Technical Efficacy<\/jats:title>\n Stage 2.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/jmri.70398","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T15:17:58Z","timestamp":1785856678000},"page":"1020-1034","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Cardiac\n MR<\/scp>\n Characterization of Infarct\u2010Related and Remote Myocardial Injury in Multivessel Disease After Acute Myocardial Infarction"],"prefix":"10.1002","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9494-404X","authenticated-orcid":false,"given":"Chun","family":"Luo","sequence":"first","affiliation":[{"name":"Department of Radiology Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University Guangzhou China"},{"name":"Department of Radiology The First People's Hospital of Foshan (Foshan Hospital Affiliated to Southern University of Science and Technology), School of Medicine, Southern University of Science and Technology Foshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Radiology Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory of Artificial Intelligence in Medical Image Analysis and Application Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caiying","family":"Mo","sequence":"additional","affiliation":[{"name":"Department of Radiology Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1861-5006","authenticated-orcid":false,"given":"Liqi","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Radiology Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7279-9876","authenticated-orcid":false,"given":"Ke","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Radiology Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruohong","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Radiology Guangzhou Baiyun District People's Hospital Guangzhou 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