{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T05:03:04Z","timestamp":1789534984857,"version":"build-2803163510"},"reference-count":46,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:00:00Z","timestamp":1781654400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:00:00Z","timestamp":1781654400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Despite promising results of artificial intelligence (AI) in prostate cancer (PCa) detection, its impact on biparametric MRI (bpMRI) interpretation remains uncertain, especially for readers with limited experience.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To evaluate the effect of AI software assistance on prostate bpMRI interpretation by readers with different levels of prostate MRI experience.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Type<\/jats:title>\n                    <jats:p>Retrospective.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Population<\/jats:title>\n                    <jats:p>Six hundred and forty\u2010six male patients, including 297 with PCa.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Field Strength\/Sequence<\/jats:title>\n                    <jats:p>\n                      3.0\u2009T;\n                      <jats:styled-content style=\"fixed-case\">T2<\/jats:styled-content>\n                      \u2010weighted imaging using fast spin echo sequence, diffusion\u2010weighted imaging using single\u2010shot echo\u2010planar imaging.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Assessment<\/jats:title>\n                    <jats:p>Two experienced readers (8 and 10\u2009years of prostate MRI experience) and two novice\u2010level readers (2\u2009years of general radiology experience; 20\u201350 prior prostate MRI cases) assessed all examinations twice, without and with AI software (uAI, United Imaging) assistance, in counterbalanced orders with a 4\u2010week washout interval. Lesions were scored using Prostate Imaging Reporting and Data System (PI\u2010RADS) v2.1 at \u2265\u20093 and \u2265\u20094 thresholds. Histopathology was the reference standard. The primary analysis defined cancer as International Society of Urological Pathology (ISUP) grade group \u2265\u20091 (Gleason score \u2265\u20096); sensitivity analysis defined clinically significant cancer as ISUP grade group \u2265\u20092.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Statistical Tests<\/jats:title>\n                    <jats:p>\n                      Generalized Estimating Equations were used for clustered data. Receiver operating characteristic (ROC) analysis with the Obuchowski\u2013Rockette model was used to compare the area under the ROC curve (AUC). Cohen's\n                      <jats:italic>\u03ba<\/jats:italic>\n                      assessed inter\u2010reader agreement; two\u2010sided\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05 indicated significance.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      For ISUP \u2265\u20091, uAI increased novice\u2010level\/experienced\u2010reader AUCs (0.684\u20130.744; 0.757\u20130.794). At PI\u2010RADS \u2265\u20093, novice\u2010level sensitivity\/specificity significantly improved (0.71\u20130.79; 0.46\u20130.58). Experienced\u2010reader sensitivity gains were nonsignificant (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.344\/0.291). For ISUP \u2265\u20092 at \u2265\u20093, all\u2010reader sensitivity\/specificity increased (0.76\u20130.82; 0.47\u20130.57). Novice\u2010level\n                      <jats:italic>\u03ba<\/jats:italic>\n                      increased at \u2265\u20093\/\u2265\u20094 (0.582\u20130.700; 0.654\u20130.741).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Conclusion<\/jats:title>\n                    <jats:p>uAI assistance improved diagnostic performance, with multi\u2010metric improvements in novice\u2010level readers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>2.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Technical Efficacy<\/jats:title>\n                    <jats:p>Stage 3.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jmri.70411","type":"journal-article","created":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T02:41:19Z","timestamp":1781750479000},"page":"972-984","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<scp>AI<\/scp>\n                    \u2010Assisted Prostate Cancer Diagnosis Using Biparametric\n                    <scp>MRI<\/scp>\n                    and\n                    <scp>PI<\/scp>\n                    \u2010\n                    <scp>RADS<\/scp>\n                    v2.1: Performance Comparison Between Novice\u2010Level and Experienced Readers"],"prefix":"10.1002","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-1654-3444","authenticated-orcid":false,"given":"Kexin","family":"Li","sequence":"first","affiliation":[{"name":"Department of Radiology The Second Affiliated Hospital of Harbin Medical University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaonan","family":"Mi","sequence":"additional","affiliation":[{"name":"Department of Radiology The Second Affiliated Hospital of Harbin Medical University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiology The Second Affiliated Hospital of Harbin Medical University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miaomiao","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Radiology The Second Affiliated Hospital of Harbin Medical University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingyan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology The Second Affiliated Hospital of Harbin Medical University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Radiology The Second Affiliated Hospital of Harbin Medical University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqiu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology The Second Affiliated Hospital of Harbin Medical University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoxuan","family":"Fei","sequence":"additional","affiliation":[{"name":"Harbin Medical University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4652-8200","authenticated-orcid":false,"given":"Kuang","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Radiology The Second Affiliated Hospital of Harbin Medical University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD012663.pub2"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1801993"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)32401-1"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2018.11.023"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00261-022-03553-x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40644-019-0274-9"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.27283"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euo.2020.02.005"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.26555"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s41747-022-00288-8"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diii.2022.11.005"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-022-08978-y"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.222276"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2019190938"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.27204"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.28427"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)00651-2"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.223128"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13244-023-01421-w"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2023.110749"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics11060973"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinimag.2019.12.010"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2025.15672"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-021-07892-z"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13133318"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLI.0000000000000780"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.3389\/fradi.2023.1153784"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.810995"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1109\/ISBI48211.2021.9434108"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.26337"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2017.03.131"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-020-07008-z"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.221309"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2025.13722"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2015.08.052"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-009-1625-x"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-023-09433-2"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.29660"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.14130448"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.26100"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(24)00220-1"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11547-022-01555-9"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-017-4805-0"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm14176111"}],"container-title":["Journal of Magnetic Resonance Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmri.70411","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jmri.70411","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmri.70411","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T04:20:11Z","timestamp":1789532411000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmri.70411"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,17]]},"references-count":46,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/jmri.70411"],"URL":"https:\/\/doi.org\/10.1002\/jmri.70411","archive":["Portico"],"relation":{},"ISSN":["1053-1807","1522-2586"],"issn-type":[{"value":"1053-1807","type":"print"},{"value":"1522-2586","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,17]]},"assertion":[{"value":"2026-03-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}