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However, whether liver iron concentration (LIC) affects MRI diagnostic performance remains uncertain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To investigate the impact of different degrees of LIC on MRI feature assessment and LI\u2010RADS v2018 category assignment in high\u2010risk HCC patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Type<\/jats:title>\n                    <jats:p>Retrospective.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Population<\/jats:title>\n                    <jats:p>One hundred sixty\u2010three consecutive HCC patients (mean age, 55.73\u2009\u00b1\u20099.65\u2009years; 152 male) with 167 lesions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Field Strength\/Sequence<\/jats:title>\n                    <jats:p>\n                      3.0\u2009T. Protocol followed LI\u2010RADS with extra sequences (\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      *, PDFF). Contrast agents included gadoxetate disodium (49 lesions), gadobenate dimeglumine (114 lesions), and Magnevist (4 lesions).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Assessment<\/jats:title>\n                    <jats:p>\n                      According to hepatic\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      * values, patients were divided into three groups: non\u2010iron overload (80 lesions), mild (54 lesions), and moderate\u2010to\u2010extreme (33 lesions). Three observers independently evaluated LI\u2010RADS v2018 major, ancillary, and LR\u2010M features, categories, and T1 signal.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Statistical Tests<\/jats:title>\n                    <jats:p>\n                      ANCOVA\/Kruskal\u2010Wallis H test, chi\u2010square\/Fisher's exact tests, and logistic regression. A two\u2010sided\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05 was considered statistically significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The incidences of T1 iso\u2010\/hyperintensity, nonperipheral \u201cwashout\u201d, enhancing \u201ccapsule\u201d and HBP hypointensity differed significantly among groups. Moderate\u2010to\u2010severe hepatic iron overload independently influenced T1 iso\u2010\/hyperintensity (OR\u2009=\u200914.38 [95% CI: 4.08\u201350.70]) and nonperipheral \u201cwashout\u201d (OR\u2009=\u20090.14 [95% CI: 0.05\u20130.41]). Hepatic iron overload was independently associated with enhancing \u201ccapsule\u201d (mild: OR\u2009=\u20090.34 [95% CI: 0.16\u20130.72]); moderate\u2010to\u2010severe: (OR\u2009=\u20090.15 [95% CI: 0.06\u20130.37]). HBP hypointensity was influenced by Child\u2010Pugh class B (OR\u2009=\u200914.51 [95% CI: 1.13\u2013185.88]), total bilirubin (OR\u2009=\u20090.09 [95% CI: 0.83\u20130.97]), albumin (OR\u2009=\u20091.49 [95% CI: 1.18\u20131.89]), PLT (OR\u2009=\u20090.99 [95% CI: 0.98\u20131.00]) and moderate\u2010to\u2010severe hepatic iron overload (OR\u2009=\u20090.01 [95% CI: 0.00\u20130.25]). Proportions of LR\u20104 and LR\u20105 differed significantly among groups, and only moderate\u2010to\u2010severe hepatic iron overload was associated with LR\u20105 assignment (OR\u2009=\u20090.08 [95% CI: 0.02\u20130.28]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Hepatic iron overload, especially moderate\u2010to\u2010extreme, may affect the visual assessment of selected MRI features and alter LI\u2010RADS v2018 category assignment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>3.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Technical Efficacy Stage<\/jats:title>\n                    <jats:p>2.<\/jats:p>\n                  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