{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:45:35Z","timestamp":1791996335779,"version":"4.4.0"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2026,11]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Zero time\u2010to\u2010echo (ZTE) imaging allows for signal acquisition from tissues with extremely short T2* relaxation times, enabling the generation of computed tomography (CT)\u2010like images through gray\u2010scale inversion.<\/jats:p>\n <\/jats:sec>\n \n Purpose<\/jats:title>\n To assess the usefulness of adding ZTE imaging to conventional MRI for the detection of hand and wrist bone erosions in rheumatoid arthritis (RA) patients, using CT as the reference method.<\/jats:p>\n <\/jats:sec>\n \n Study Type<\/jats:title>\n Prospective.<\/jats:p>\n <\/jats:sec>\n \n Subjects<\/jats:title>\n Fifteen patients with RA (4 male and 11 female; mean age, 61.8\u2009\u00b1\u200915.5\u2009years) participated in this study.<\/jats:p>\n <\/jats:sec>\n \n Field Strength\/Sequence<\/jats:title>\n 3\u2010T, T1\u2010weighted image (fast spin echo), T2\u2010weighted image (fast spin echo), ZTE imaging (gradient echo).<\/jats:p>\n <\/jats:sec>\n \n Assessment<\/jats:title>\n Three radiologists independently evaluated bone erosions on plain radiography, conventional MRI, and ZTE imaging using a four\u2010point scale (0\u2009=\u2009normal; 1\u2009=\u2009discrete erosion; 2\u2009\u2264\u200950% of joint surface involvement; 3\u2009\u2265\u200950%). Bone erosion was defined as a sharply delineated juxta\u2010articular lesion with a cortical defect. A total of 25 anatomical sites per hand and wrist were assessed, including the distal radius and ulna, eight carpal bones, metacarpal bases, and proximal and distal aspects of the metacarpophalangeal joints. CT was interpreted by a musculoskeletal radiologist and served as the reference standard.<\/jats:p>\n <\/jats:sec>\n \n Statistical Tests<\/jats:title>\n \n Diagnostic performance (sensitivity and specificity) was compared with the McNemar test, and interobserver variability was assessed using Fleiss \u03ba statistics.\n p<\/jats:italic>\n values less than 0.01 were considered significant.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The sensitivity and specificity of plain radiography, conventional MRI, and ZTE were 40.6\/98.9%, 72.6\/94.6%, and 95.9\/97.6%, respectively. Interobserver agreement on bone erosion assessment was excellent for ZTE imaging (\n \u03ba<\/jats:italic>\n value of 0.822) but fair for plain radiography (\n \u03ba<\/jats:italic>\n value of 0.427) and good for conventional MRI (\n \u03ba<\/jats:italic>\n value of 0.711).\n <\/jats:p>\n <\/jats:sec>\n \n Data Conclusions<\/jats:title>\n ZTE imaging can provide reliable bone erosion assessment in RA patients.<\/jats:p>\n <\/jats:sec>\n \n Level of Evidence<\/jats:title>\n 2.<\/jats:p>\n <\/jats:sec>\n \n Technical Efficacy<\/jats:title>\n Stage 2.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/jmri.70420","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T04:14:53Z","timestamp":1783656893000},"page":"1337-1343","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Zero Time\u2010to\u2010Echo Imaging of the Hand and Wrist in Rheumatoid Arthritis Patients"],"prefix":"10.1002","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-7466-8483","authenticated-orcid":false,"given":"Jun","family":"Tsukamoto","sequence":"first","affiliation":[{"name":"Department of Radiology University of Occupational and Environmental Health Kitakyushu Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akitaka","family":"Fujisaki","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Occupational and Environmental Health Kitakyushu Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiko","family":"Hayashida","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Occupational and Environmental Health Kitakyushu Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiichi","family":"Murakami","sequence":"additional","affiliation":[{"name":"Department of Radiological Science, Faculty of Health Sciences Junshin Gakuen University Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0383-1091","authenticated-orcid":false,"given":"Atsushi","family":"Nagayasu","sequence":"additional","affiliation":[{"name":"The First Department of Internal Medicine University of Occupational and Environmental Health Kitakyushu Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4646-592X","authenticated-orcid":false,"given":"Yasuyuki","family":"Todoroki","sequence":"additional","affiliation":[{"name":"The First Department of Internal Medicine University of Occupational and Environmental Health Kitakyushu Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2209-8454","authenticated-orcid":false,"given":"Shingo","family":"Nakayamada","sequence":"additional","affiliation":[{"name":"The First Department of Internal Medicine University of Occupational and Environmental Health Kitakyushu Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0807-7139","authenticated-orcid":false,"given":"Yoshiya","family":"Tanaka","sequence":"additional","affiliation":[{"name":"The First Department of Internal Medicine University of Occupational and Environmental Health Kitakyushu Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7973-110X","authenticated-orcid":false,"given":"Takatoshi","family":"Aoki","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Occupational and Environmental Health Kitakyushu Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,9]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)30173-8"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2008.11.006"},{"issue":"6","key":"e_1_2_9_4_1","first-page":"1387","article-title":"OMERACT Rheumatoid Arthritis Magnetic Resonance Imaging Studies. 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