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DMRI has been used in whole\u2010body imaging as well as in targeted imaging of every major anatomical region. Most clinical dMRI applications use a standard acquisition technique: the pulsed gradient spin echo (PGSE) preparation with echo planar imaging (EPI) readout. PGSE creates strong diffusion contrast while removing the effect of\n                    <jats:italic>T<\/jats:italic>\n                    <jats:sub>2<\/jats:sub>\n                    *, and EPI enables imaging of an entire 2D slice in a single shot. The PGSE\u2010EPI method is rapid and robust; however, it is limited by low resolution and distortions typically caused by motion and susceptibility artifacts. Since the inception of dMRI, other methods have been used to sensitize diffusion and to read out the signal, which overcome different weaknesses of PGSE\u2010EPI. These methods have largely been developed and used in the brain, but many of them have been applied to body dMRI as well. This review describes the major families of non\u2010standard techniques used in body dMRI, covering both diffusion encoding strategies as well as image readout strategies. It then explores how these techniques have been applied in non\u2010brain clinical applications and assesses the strengths and benefits of each method in various clinical contexts. Non\u2010standard acquisition techniques have the potential to improve the value and efficiency of dMRI in the body, and further work to standardize and validate these sequences will enable their use in clinical contexts.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Evidence Level:<\/jats:bold>\n                    3.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Technical Efficacy:<\/jats:bold>\n                    2.\n                  <\/jats:p>","DOI":"10.1002\/jmri.70451","type":"journal-article","created":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T14:38:56Z","timestamp":1784039936000},"page":"881-897","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Diffusion\n                    <scp>MRI<\/scp>\n                    of the Body: Beyond\n                    <scp>PGSE<\/scp>\n                    \u2010\n                    <scp>EPI<\/scp>"],"prefix":"10.1002","volume":"64","author":[{"given":"Matthew T.","family":"Cherukara","sequence":"first","affiliation":[{"name":"School of Biomedical Engineering and Imaging Sciences King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbo","family":"Sun","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering and Imaging Sciences King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5853-8602","authenticated-orcid":false,"given":"David","family":"Leit\u00e3o","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering and Imaging Sciences King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8925-9032","authenticated-orcid":false,"given":"Shaihan","family":"Malik","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering and Imaging Sciences King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6543-4390","authenticated-orcid":false,"given":"Radhouene","family":"Neji","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering and Imaging Sciences King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph V.","family":"Hajnal","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering and Imaging Sciences King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9893-1724","authenticated-orcid":false,"given":"Andrada","family":"Ianus","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering and Imaging Sciences King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,14]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.1940080711"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.25550"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00261\u2010025\u201005102\u20108"},{"issue":"2","key":"e_1_2_10_5_1","first-page":"107","article-title":"Diffusion\u2010Weighted MRI of the Liver: Challenges and Some Solutions for the Quantification of Apparent Diffusion Coefficient and Intravoxel Incoherent Motion","volume":"11","author":"Wang Y. 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