{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:45:36Z","timestamp":1791996336928,"version":"4.4.0"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T00:00:00Z","timestamp":1784246400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T00:00:00Z","timestamp":1784246400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The feasibility of multi\u2010frequency magnetic resonance elastography (MRE) for ovarian assessment, normative stiffness values, and related influencing factors in the general population remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To evaluate ovarian MRE feasibility, preferred frequency, normative stiffness, and influencing factors in healthy individuals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Type<\/jats:title>\n                    <jats:p>Prospective.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Subjects<\/jats:title>\n                    <jats:p>About 55 healthy female volunteers (median age: 42; median body mass index (BMI): 23).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Field Strength\/Sequence<\/jats:title>\n                    <jats:p>3\u2009T; spin\u2010echo echo\u2010planar imaging sequence at 40, 60, and 80\u2009Hz.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Assessment<\/jats:title>\n                    <jats:p>Quality\u2010control metrics and ovarian stiffness values (left and right) were measured for all participants. Image quality was evaluated by IQS (1\u20134; diagnostic images \u2265\u20093) and confidence percentage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Statistical Tests<\/jats:title>\n                    <jats:p>\n                      Intraclass correlation coefficient (ICC); ANOVA; multivariate linear regression; significance level,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Quality\u2010control metrics, including fixed\u2010ROI average phase SD [138.63 (106.17\u2013177.74), 127.90 (97.77\u2013186.46), and 133.70 (92.73\u2013185.79)] and average within\u2010ROI phase range [605.25 (468.43\u2013777.50), 604.00 (432.83\u2013821.50), and 607.00 (442.00\u2013804.80)] at 40, 60, and 80\u2009Hz, showed no significant frequency\u2010dependent variation (both\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.947), confirming no substantial vibration\u2010induced phase artifacts. Combined with good\u2010to\u2010excellent reproducibility (ICCs: 0.897\u20130.999), these data supported the feasibility of ovarian MRE. Among tested frequencies, 60\u2009Hz showed relatively favorable image quality, the highest IQS agreement (inter\u2010reader\/intra\u2010reader weighted\n                      <jats:italic>\u03ba<\/jats:italic>\n                      \u2009=\u20090.828\u20130.891\/0.862\u20130.877). Ovarian stiffness ranges were 1.56\u20132.91, 2.91\u20133.70, and 3.10\u20133.89\u2009kPa in the premenopausal, perimenopausal, and postmenopausal groups, respectively. Ovarian stiffness remained stable across menstrual\u2010cycle phases in either ovary (left\/right:\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.250\/0.358, 0.986\/0.858, 0.088\/0.476, 0.249\/0.448, 0.633\/0.185, and 0.120\/0.706). Regression analysis identified age and BMI as independent predictors of ovarian stiffness; age had a larger standardized\n                      <jats:italic>\u03b2<\/jats:italic>\n                      than BMI (0.868 vs. 0.176), as did menopausal status when replacing age (0.832 vs. 0.213).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Conclusions<\/jats:title>\n                    <jats:p>About 60\u2009Hz provided appropriate MRE images in healthy volunteers. Ovarian stiffness was influenced by menopausal status, age, and BMI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Evidence Level<\/jats:title>\n                    <jats:p>2.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Technical Efficacy<\/jats:title>\n                    <jats:p>Stage 1.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jmri.70455","type":"journal-article","created":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T13:37:33Z","timestamp":1784295453000},"page":"1215-1226","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Probing Ovarian Stiffness in Healthy Volunteers With\n                    <scp>3D<\/scp>\n                    Magnetic Resonance Elastography"],"prefix":"10.1002","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-7523-2742","authenticated-orcid":false,"given":"Huiting","family":"Cao","sequence":"first","affiliation":[{"name":"Department of Radiology, Shengjing Hospital China Medical University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Shengjing Hospital China Medical University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6359-5670","authenticated-orcid":false,"given":"Qiang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Radiology, Shengjing Hospital China Medical University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiology, 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