{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T08:45:20Z","timestamp":1792053920707,"version":"4.4.0"},"reference-count":42,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:00:00Z","timestamp":1792022400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:00:00Z","timestamp":1792022400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171895"],"award-info":[{"award-number":["82171895"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82572170"],"award-info":[{"award-number":["82572170"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Type 1 diabetes mellitus (T1DM) increases fracture risk beyond bone mineral density (BMD), implicating matrix quality. Whether ultrashort echo time magnetization transfer (UTE\u2010MT) MRI can track collagen alterations in T1DM and their associations with mineralization is unknown.<\/jats:p>\n <\/jats:sec>\n \n Purpose<\/jats:title>\n To evaluate UTE\u2010MT\u2010derived magnetization transfer ratio (MTR) for monitoring in\u00a0vivo cortical collagen alterations in T1DM and to investigate its associations with mineralization and multiscale bone properties.<\/jats:p>\n <\/jats:sec>\n \n Study Type<\/jats:title>\n Longitudinal animal model.<\/jats:p>\n <\/jats:sec>\n \n Animal Model<\/jats:title>\n \n 18 male New Zealand white rabbits (Age: 5\u20136\u2009months) randomized to diabetic (\n n<\/jats:italic>\n \u2009=\u200912) and control (\n n<\/jats:italic>\n \u2009=\u20096) groups.\n <\/jats:p>\n <\/jats:sec>\n \n Field Strength\/Sequence<\/jats:title>\n 3\u2009T\/3D gradient\u2010echo UTE\u2010MT sequence.<\/jats:p>\n <\/jats:sec>\n \n Assessment<\/jats:title>\n UTE\u2010MT MRI was performed at baseline (week 0) and weeks 12, 16, and 20 post\u2010alloxan induction. Cortical MTR was calculated from paired MT\u2010on\/off images and quantified over cortical regions of interest. Reference measurements at the terminal time point (week 20) included micro\u2010CT (cortical porosity [CtPo]), histomorphometry (mineral apposition rate [MAR], bone formation rate [BFR\/BS]), fourier transform infrared spectroscopy (FT\u2010IR) (collagen cross\u2010linking), liquid chromatography\u2013tandem mass spectrometry (LC\u2013MS\/MS) (hydroxyproline [Hyp]), histology (collagen maturation), and mechanical testing.<\/jats:p>\n <\/jats:sec>\n \n Statistical Tests<\/jats:title>\n \n The\n t<\/jats:italic>\n \u2010tests\/Mann\u2013Whitney U for endpoint cross\u2010sectional comparisons, linear mixed\u2010effects model for longitudinal MTR, Pearson correlations (\n r<\/jats:italic>\n ) for associations;\n p<\/jats:italic>\n \u2009<\u20090.05 was considered significant.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Cortical MTR declined in T1DM rabbits, becoming significantly lower than controls at week 12 and lowest at week 20. At termination, T1DM group demonstrated significantly higher CtPo (1.345\u2009\u00b1\u20090.270% vs. 0.591\u2009\u00b1\u20090.233%), elevated NE\u2010xLR, reduced MAR, BFR\/BS, Hyp, ECR, and collagen maturation (1.705\u2009\u00b1\u20090.548 vs. 5.474\u2009\u00b1\u20091.455). Mechanical properties (elastic modulus [E], yield strength [YS], toughness) were significantly lower in the T1DM group, with reductions of 44.1%, 35.2%, and 63.2% relative to controls, respectively. MTR at week 20 correlated positively with Hyp, ECR, collagen maturation, mineralization, and mechanical parameters (\n r<\/jats:italic>\n \u2009=\u20090.562 to 0.900), and negatively with NE\u2010xLR via partial correlation (\n r<\/jats:italic>\n \u2009=\u2009\u22120.616) and CtPo (\n r<\/jats:italic>\n \u2009=\u2009\u22120.826).\n <\/jats:p>\n <\/jats:sec>\n \n Data Conclusions<\/jats:title>\n UTE\u2010MT\u2010derived MTR enables in\u00a0vivo tracking of cortical collagen dynamics in T1DM.<\/jats:p>\n <\/jats:sec>\n \n Evidence Level<\/jats:title>\n 1.<\/jats:p>\n <\/jats:sec>\n \n Technical Efficacy<\/jats:title>\n Stage 2.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/jmri.70457","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T08:01:36Z","timestamp":1792051296000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ultrashort Echo Time Magnetization Transfer\n MRI<\/scp>\n for Cortical Bone Collagen Assessment and Its Association With Mineralization in Type 1 Diabetes"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-1746-555X","authenticated-orcid":false,"given":"Minzhi","family":"Pei","sequence":"first","affiliation":[{"name":"Department of Radiology Renmin Hospital of Wuhan University Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanyun","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Radiology Renmin Hospital of Wuhan University Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7917-7612","authenticated-orcid":false,"given":"Weiyin Vivian","family":"Liu","sequence":"additional","affiliation":[{"name":"MR Research, GE Healthcare Beijing 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