{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T22:07:03Z","timestamp":1784930823307,"version":"3.55.0"},"reference-count":31,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["25K19115"],"award-info":[{"award-number":["25K19115"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007449","name":"Takeda Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007449","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Assessment of amyloid\u2010\u03b2 (A\u03b2) burden and associated iron deposition and neurodegeneration is important for Alzheimer's disease (AD) management. Although quantitative susceptibility mapping (QSM) detects iron and myelin changes, conventional metrics suffer from signal cancelation between paramagnetic and diamagnetic components. Consequently, spatial interactions between these independent susceptibility sources and A\u03b2 burden remain unestablished.<\/jats:p>\n <\/jats:sec>\n \n Purpose<\/jats:title>\n To investigate spatial associations between regional A\u03b2 burden and independent paramagnetic and diamagnetic susceptibility sources using \u03c7\u2010separation.<\/jats:p>\n <\/jats:sec>\n \n Study Type<\/jats:title>\n Prospective.<\/jats:p>\n <\/jats:sec>\n \n Population<\/jats:title>\n \n A total of 77 participants with mild cognitive impairment or dementia (mean age, 74\u2009years; women, 50) examined using QSM and amyloid positron emission tomography (PET) (\n 18<\/jats:sup>\n F\u2010flutemetamol or\n 18<\/jats:sup>\n F\u2010florbetapir).\n <\/jats:p>\n <\/jats:sec>\n \n Field Strength\/Sequence<\/jats:title>\n 3\u2009T\/QSM (3\u2010dimensional multi\u2010echo gradient\u2010echo sequence).<\/jats:p>\n <\/jats:sec>\n \n Assessment<\/jats:title>\n \u03c7\u2010separation decomposed QSM data into paramagnetic (\u03c7\u2010para) and diamagnetic (\u03c7\u2010dia) components. Centiloid\u2010scale maps standardized PET quantification for voxel\u2010wise analysis. The spatial relationship between A\u03b2 load and susceptibility metrics was analyzed using voxel\u2010wise correlations within AD\u2010signature cortical regions.<\/jats:p>\n <\/jats:sec>\n \n Statistical Tests<\/jats:title>\n Voxel\u2010wise spatial associations between Centiloid values and QSM metrics were evaluated using Pearson's coefficients. Spatial association was considered statistically significant if the 99% confidence interval (CI) did not cross zero.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Conventional QSM showed near\u2010zero cortical susceptibility and obscured pathological details owing to physiological cancelation. \u03c7\u2010separation unmasked susceptibility sources. Local A\u03b2 deposition was consistently associated with reduced absolute \u03c7\u2010dia across cortical regions (mean\n r<\/jats:italic>\n range: \u22120.267 to \u22120.098; all 99% CIs did not cross zero), consistent with alterations in net diamagnetic susceptibility sources, potentially involving myelin\u2010related components. \u03c7\u2010para showed weaker and regionally heterogeneous associations with A\u03b2 burden, with a positive association most evident in the precuneus (mean\n r<\/jats:italic>\n \u2009=\u20090.072, 99% CI: 0.052\u20130.092).\n <\/jats:p>\n <\/jats:sec>\n \n Data Conclusion<\/jats:title>\n \u03c7\u2010separation reveals region\u2010specific cortical alteration associated with regional A\u03b2 pathology. By separating these susceptibility sources, this method may provide complementary information to conventional QSM, offering a refined, noninvasive approach for characterizing amyloid\u2010associated tissue changes in AD.<\/jats:p>\n <\/jats:sec>\n \n Evidence Level<\/jats:title>\n 2.<\/jats:p>\n <\/jats:sec>\n \n Technical Efficacy<\/jats:title>\n Stage 2.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/jmri.70458","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T21:34:40Z","timestamp":1784928880000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Amyloid\u2010\u03b2\u2013Related Cortical Susceptibility Alterations in Individuals Under Assessment for Alzheimer's Disease: A \u03c7\u2010Separation 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