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However, studies on intra\u2010organ distribution of ectopic fat in the pediatric obese population remain limited.<\/jats:p>\n <\/jats:sec>\n \n Purpose<\/jats:title>\n To assess MRI\u2010based spatial distribution patterns of hepatic and pancreatic fat using a fully automated nnU\u2010Net model and evaluate their association with biochemical risk markers.<\/jats:p>\n <\/jats:sec>\n \n Study Type<\/jats:title>\n Prospective.<\/jats:p>\n <\/jats:sec>\n \n Subject<\/jats:title>\n \n Eighty\u2010one pediatric patients (age: 12 [11, 13] years, 57 males) with overweight or obesity based on body mass index\n z<\/jats:italic>\n \u2010score.\n <\/jats:p>\n <\/jats:sec>\n \n Field Strength\/Sequence<\/jats:title>\n \n 1.5\u2009T, gradient\u2010echo modified\u2010DIXON T\n 1<\/jats:sub>\n W.\n <\/jats:p>\n <\/jats:sec>\n \n Assessment<\/jats:title>\n The spatial distribution of fat in liver and pancreas, the correlations between hepatic and pancreatic fat fraction (FF), and the association between the fat measures and biochemical risk markers were evaluated.<\/jats:p>\n <\/jats:sec>\n \n Statistical Tests<\/jats:title>\n \n Paired Wilcoxon test or\n t<\/jats:italic>\n \u2010test, repeated measure ANOVA or Friedman's test, Kruskal\u2013Wallis test, Spearman correlation analysis. Significance was set at\n p<\/jats:italic>\n \u2009<\u20090.05.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Hepatic FF was significantly higher in the right lobe (median, 16.22%) than in the left lobe (median, 10.43%), and increased with distance from the portal vein. The degree of hepatic fat heterogeneity increased with the amount of fat deposition (whole variance: Level 0: 4.10; Level 1: 11.53; Level 2: 28.94; Level 3: 31.21). Then, the FF and its variance in the pancreatic body and tail were significantly higher than those in the head. A weak but statistically significant correlation (\n r<\/jats:italic>\n range, 0.29\u20130.38) was observed between hepatic and pancreatic FF. Hepatic FF correlated with triglyceride and apolipoprotein B, but pancreatic fat showed no association (\n p<\/jats:italic>\n range, 0.096\u20130.994) with lipid profiles, HOMA\u2010IR, or HOMA\u2010\u03b2.\n <\/jats:p>\n <\/jats:sec>\n \n Data Conclusion<\/jats:title>\n Intra\u2010hepatic and intra\u2010pancreatic fat were heterogeneously distributed in pediatric obese population. Although fat accumulation in the liver and pancreas was weakly correlated, hepatic and pancreatic fat may arise from distinct metabolic disorders.<\/jats:p>\n <\/jats:sec>\n \n Evidence Level<\/jats:title>\n 2.<\/jats:p>\n <\/jats:sec>\n \n Technical Efficacy<\/jats:title>\n Stage 1.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/jmri.70496","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T06:51:25Z","timestamp":1786603885000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Associations Between Biochemical Risk Markers and\n MRI<\/scp>\n \u2010Determined Ectopic Fat Distribution in Liver and Pancreas of Pediatric Obesity"],"prefix":"10.1002","author":[{"given":"Yan\u2010Ci","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Radiology The First Affiliated Hospital, Zhejiang University School of Medicine Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Cao","sequence":"additional","affiliation":[{"name":"Key Laboratory for Biomedical Engineering of Ministry of Education, College of Biomedical Engineering and Instrument Science Zhejiang University Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan\u2010Hong","family":"Mi","sequence":"additional","affiliation":[{"name":"Department of Radiology Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents' Health and Diseases Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng\u2010Yu","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Radiology Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents' Health and Diseases Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong\u2010Xi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiology Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents' Health and Diseases Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia\u2010Qiang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Sir Run Run Shaw Hospital, Zhejiang University School of Medicine Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4084-5150","authenticated-orcid":false,"given":"Hong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory for Biomedical Engineering of Ministry of Education, College of Biomedical Engineering and Instrument Science Zhejiang University Hangzhou Zhejiang China"},{"name":"Department of Nuclear Medicine and PET Center The Second Affiliated Hospital of Zhejiang University School of Medicine Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6405-1251","authenticated-orcid":false,"given":"Jun\u2010Fen","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents' Health and Diseases Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4402-4955","authenticated-orcid":false,"given":"Feng","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiology The First Affiliated Hospital, Zhejiang University School of Medicine Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1072-5983","authenticated-orcid":false,"given":"Min","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory for Biomedical Engineering of Ministry of Education, College of Biomedical Engineering and Instrument Science Zhejiang University Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,12]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"crossref","DOI":"10.1186\/s12916-019-1449-8","article-title":"The Epidemiological Burden of Obesity in Childhood: A Worldwide Epidemic Requiring Urgent Action","volume":"17","author":"Di Cesare M.","year":"2019","journal-title":"BMC Medicine"},{"key":"e_1_2_12_3_1","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2020.600439","article-title":"Metformin Use Is Associated With Reduced Mortality in a Diverse Population With COVID\u201019 and Diabetes","volume":"11","author":"Crouse A. 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