{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T08:30:40Z","timestamp":1786523440070,"version":"build-2736575974"},"reference-count":38,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01EB017337"],"award-info":[{"award-number":["R01EB017337"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HD114338"],"award-info":[{"award-number":["R01HD114338"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21HD106553"],"award-info":[{"award-number":["R21HD106553"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Placental MRI has shown T2* decreases during contractions and increases during maternal hyperoxia. However, how contraction\u2010induced placental oxygenation and deformation relate to uterine deformation and differ from hyperoxia\u2010induced responses remains unknown.<\/jats:p>\n <\/jats:sec>\n \n Purpose<\/jats:title>\n To quantify placental T2* and deformation changes during spontaneous non\u2010labor uterine contractions and maternal hyperoxia, testing the hypothesis that contractions produce mechanically mediated placental responses distinct from hyperoxia.<\/jats:p>\n <\/jats:sec>\n \n Study Type<\/jats:title>\n Retrospective.<\/jats:p>\n <\/jats:sec>\n \n Population<\/jats:title>\n Forty\u2010nine MRI datasets from 46 pregnant participants with singleton pregnancies (24\u201339\u2009weeks gestation).<\/jats:p>\n <\/jats:sec>\n \n Field Strength\/Sequence<\/jats:title>\n 3\u2009T; dynamic multi\u2010echo gradient\u2010echo echo\u2010planar imaging.<\/jats:p>\n <\/jats:sec>\n \n Assessment<\/jats:title>\n \n Non\u2010labor uterine contractions were defined as events lasting \u2265\u20090.5\u2009min with peak uterine volume reduction >\u20092.5%. Placental T2* and deformation of the uterus, myometrium, placenta, fetus and amniotic fluid were quantified during normoxia (normal air, 21% O\n 2<\/jats:sub>\n , 5\u2009min) with and without contractions, and maternal hyperoxia (100% FiO\n 2<\/jats:sub>\n , 4\u2009min). Regional analyses were performed within and outside imaging\u2010defined placental cotyledons.\n <\/jats:p>\n <\/jats:sec>\n \n Statistical Tests<\/jats:title>\n \n Linear regression, linear mixed\u2010effects models, Pearson correlation and paired t\u2010tests (\n p<\/jats:italic>\n \u2009<\u20090.05).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Complete contractions during normoxia were identified in 22 datasets, reducing placental T2* by 4.64\u2009\u00b1\u20090.75\u2009ms. Maternal hyperoxia increased placental T2* by 11.36\u2009\u00b1\u20090.62\u2009ms relative to normoxia. Significant gestational age\u2010by\u2010duration interactions were observed for contraction\u2010associated placental deformation (\n \u03b2<\/jats:italic>\n \u2009=\u20092.47\u2009\u00b1\u20091.04% points\/min\/week) and T2* reduction (\n \u03b2<\/jats:italic>\n \u2009=\u20091.50\u2009\u00b1\u20090.44\u2009ms\/min\/week). At baseline, cotyledons exhibited higher T2* than surrounding placental tissue (\n \u03b2<\/jats:italic>\n \u2009=\u2009\u221211.56\u2009\u00b1\u20090.95\u2009ms). Contractions significantly reduced the inside\u2013outside cotyledon T2* difference (\n \u03b2<\/jats:italic>\n \u2009=\u20093.14\u2009\u00b1\u20091.34\u2009ms), whereas hyperoxia preserved regional heterogeneity (\n p<\/jats:italic>\n \u2009=\u20090.48).\n <\/jats:p>\n <\/jats:sec>\n \n Data Conclusion<\/jats:title>\n Spontaneous non\u2010labor uterine contractions induced coordinated decreases in placental volume and oxygenation that intensified with gestational age and contraction duration. In contrast, maternal hyperoxia produced larger, more uniform increases in oxygenation.<\/jats:p>\n <\/jats:sec>\n \n Evidence Level<\/jats:title>\n 3.<\/jats:p>\n <\/jats:sec>\n \n Technical Efficacy<\/jats:title>\n Stage 3.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/jmri.70500","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T07:51:11Z","timestamp":1786521071000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Uteroplacental Responses to Physiological Challenges Throughout Pregnancy Using\n MRI<\/scp>"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0246-8793","authenticated-orcid":false,"given":"Esra","family":"Abaci Turk","sequence":"first","affiliation":[{"name":"Fetal\u2010Neonatal Neuroimaging & Developmental Science Center Boston Children's Hospital, Harvard Medical School Boston Massachusetts USA"},{"name":"Harvard Medical School Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neel","family":"Dey","sequence":"additional","affiliation":[{"name":"Computer Science and Artificial Intelligence Laboratory (CSAIL) Massachusetts Institute of Technology Cambridge Massachusetts USA"},{"name":"Department of Radiology Harvard Medical School Boston Massachusetts USA"},{"name":"Athinoula A. Martinos Center for Biomedical Imaging Massachusetts General Hospital Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7294-7742","authenticated-orcid":false,"given":"Tiantian","family":"Lei","sequence":"additional","affiliation":[{"name":"Fetal\u2010Neonatal Neuroimaging & Developmental Science Center Boston Children's Hospital, Harvard Medical School Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1748-0894","authenticated-orcid":false,"given":"Henry A.","family":"Feldman","sequence":"additional","affiliation":[{"name":"Harvard Medical School Boston Massachusetts USA"},{"name":"Biostatistics and Research Design Center Boston Children's Hospital, Harvard Medical School Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elfar","family":"Adalsteinsson","sequence":"additional","affiliation":[{"name":"Department of Electrical Engineering and Computer Science Massachusetts Institute of Technology Cambridge Massachusetts USA"},{"name":"Harvard\u2010MIT Health Sciences and Technology Massachusetts Institute of Technology Cambridge Massachusetts USA"},{"name":"Institute for Medical Engineering and Science Massachusetts Institute of Technology Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"William H.","family":"Barth","sequence":"additional","affiliation":[{"name":"Maternal\u2010Fetal Medicine, Obstetrics and Gynecology Massachusetts General Hospital Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Polina","family":"Golland","sequence":"additional","affiliation":[{"name":"Computer Science and Artificial Intelligence Laboratory (CSAIL) Massachusetts Institute of Technology Cambridge Massachusetts USA"},{"name":"Department of Electrical Engineering and Computer Science Massachusetts Institute of Technology Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1005-4013","authenticated-orcid":false,"given":"P. 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