{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T16:54:06Z","timestamp":1792083246065,"version":"4.4.0"},"reference-count":38,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n The clinical relevance of the epicardial adipose tissue index (EATI) is increasingly recognized, but its association with clinical outcomes in patients with heart failure with preserved ejection fraction (HFpEF) remains inadequately investigated.<\/jats:p>\n <\/jats:sec>\n \n Purpose<\/jats:title>\n To evaluate the association between cardiac MRI\u2010derived EATI and major adverse cardiovascular events (MACE) in patients with HFpEF.<\/jats:p>\n <\/jats:sec>\n \n Study Type<\/jats:title>\n Retrospective.<\/jats:p>\n <\/jats:sec>\n \n Population<\/jats:title>\n Two hundred sixty\u2010five patients with HFpEF (135 male; mean age 55\u2009years).<\/jats:p>\n <\/jats:sec>\n \n Field Strength\/Sequence<\/jats:title>\n 1.5\u2009T\/balanced steady\u2010state free precession.<\/jats:p>\n <\/jats:sec>\n \n Assessment<\/jats:title>\n EATI was quantified on cardiac MRI cine images. MACE was defined as cardiac death or readmission for heart failure.<\/jats:p>\n <\/jats:sec>\n \n Statistical Tests<\/jats:title>\n \n Welch\n t<\/jats:italic>\n \u2010test or Mann\u2013Whitney\n U<\/jats:italic>\n test, Cox proportional hazards regression, Kaplan\u2013Meier analysis with log\u2010rank test, and global\n \u03c7<\/jats:italic>\n 2<\/jats:sup>\n model comparison. A\n p<\/jats:italic>\n value <\u20090.05 was considered significant.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n During a median follow\u2010up of 33\u2009months (22\u201065), 42 patients experienced MACE. EATI was significantly higher in the MACE group than in the no\u2010MACE group (33.65\u2009\u00b1\u200913.91 vs. 26.13\u2009\u00b1\u200911.28\u2009mL\/m\n 2<\/jats:sup>\n ,\n Z<\/jats:italic>\n \u2009=\u2009\u22123.52, effect size\n r<\/jats:italic>\n \u2009=\u2009\u22120.22). EATI was independently associated with MACE (multivariable HR\u2009=\u20091.04 [95% CI: 1.01\u20131.06]). Kaplan\u2013Meier survival analysis confirmed that patients with low EATI had significantly higher event\u2010free survival rate. A model combining EATI with other clinical and conventional imaging risk factors (\n \u03c7<\/jats:italic>\n 2<\/jats:sup>\n \u2009=\u200942.3) showed significantly improved model discrimination for identifying patients at risk of MACE compared with models with clinical variables (\n \u03c7<\/jats:italic>\n 2<\/jats:sup>\n \u2009=\u200926.0) or clinical and conventional imaging variables (\n \u03c7<\/jats:italic>\n 2<\/jats:sup>\n \u2009=\u200934.3).\n <\/jats:p>\n <\/jats:sec>\n \n Data Conclusion<\/jats:title>\n Cardiac MRI\u2010derived EATI was independently associated with MACE in patients with HFpEF and showed favorable discriminatory performance compared with clinical and conventional imaging risk factors.<\/jats:p>\n <\/jats:sec>\n \n Evidence Level<\/jats:title>\n 3.<\/jats:p>\n <\/jats:sec>\n \n Technical Efficacy<\/jats:title>\n Stage 5.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/jmri.70554","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:27:24Z","timestamp":1792034844000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Association of Cardiac\n MRI<\/scp>\n \u2010Derived Epicardial Adipose Tissue Index With Adverse Clinical Outcomes in Heart Failure With Preserved Ejection Fraction"],"prefix":"10.1002","author":[{"given":"Siying","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Radiology Sir Run Run Shaw Hospital, Zhejiang University School of Medicine Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lujie","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Radiology Sir Run Run Shaw Hospital, Zhejiang University School of Medicine Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaihua","family":"Lou","sequence":"additional","affiliation":[{"name":"Department of Radiology Sir Run Run Shaw Hospital, Zhejiang University School of Medicine Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4051-0913","authenticated-orcid":false,"given":"Qiuhui","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Radiology Sir Run Run Shaw Hospital, Zhejiang University School of Medicine Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6485-8837","authenticated-orcid":false,"given":"Xi","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Radiology Sir Run Run Shaw Hospital, Zhejiang University School of Medicine Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feidan","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Radiology Sir Run Run Shaw Hospital, Zhejiang University School of Medicine Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingjie","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiology Sir Run Run Shaw Hospital, Zhejiang University School of Medicine Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology Sir Run Run Shaw Hospital, Zhejiang University School of Medicine Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8341-9038","authenticated-orcid":false,"given":"Yiyuan","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Radiology Beijing Friendship Hospital, Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9859-5860","authenticated-orcid":false,"given":"Hongjie","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Radiology Sir Run Run Shaw Hospital, Zhejiang University School of Medicine Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,14]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1038\/s41569-024-01046-6","article-title":"Global Epidemiology of Heart Failure","volume":"21","author":"Khan M. 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