{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T09:03:44Z","timestamp":1790845424960,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["R01 AR067789"],"award-info":[{"award-number":["R01 AR067789"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["R01 AR082225"],"award-info":[{"award-number":["R01 AR082225"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["R01 AR082670"],"award-info":[{"award-number":["R01 AR082670"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The progression of early osteoarthritis (OA) is difficult to predict radiographically. T2 mapping provides information about cartilage degeneration, but its sensitivity to early matrix injury is limited. Diffusion tensor imaging (DTI) may detect cartilage microstructural abnormalities beyond T2 mapping.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To test whether baseline cartilage DTI metrics are associated with early knee OA and 3\u2010year radiographic progression, and to compare their performance with T2 mapping and baseline Whole\u2010Organ Magnetic Resonance Imaging Score (WORMS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Type<\/jats:title>\n                    <jats:p>Prospective longitudinal cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Population<\/jats:title>\n                    <jats:p>Seventy\u2010one participants (40 female, 31 male): 60 with unilateral symptomatic OA (one knee Kellgren\u2013Lawrence [KL]\u2009\u2265\u20092, contralateral KL\u2009=\u20091) and 11 asymptomatic controls; 40 OA participants had 3\u2010year follow\u2010up radiographs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Field Strength\/Sequence<\/jats:title>\n                    <jats:p>3T, radial spin\u2010echo diffusion (RAISED) DTI and multi\u2010echo spin\u2010echo T2 mapping.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Assessment<\/jats:title>\n                    <jats:p>KL grade, joint space width, baseline WORMS, and cartilage segmentations were obtained. Mean diffusivity (MD), fractional anisotropy, axial diffusivity, radial diffusivity (RD), and T2 were calculated in six cartilage regions. Progression was defined as joint space narrowing (JSN) &gt;\u20090.7\u2009mm or any KL grade increase.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Statistical Tests<\/jats:title>\n                    <jats:p>\n                      ANCOVA adjusted for age, sex, and body mass index. Discrimination was assessed with the area under the receiver operating characteristic curve (AUC); predictive models were evaluated using cross\u2010validated AUC. A two\u2010sided\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05 was considered statistically significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Baseline medial femoral condyle (MFC) MD distinguished KL\u2009=\u20090 from KL \u2265\u20091 knees (AUC 0.90), whereas a T2\u2010based model showed lower discrimination (AUC 0.55). Among KL\u2009=\u20091 knees, 30% showed JSN progression and 28% KL progression. Baseline MFC MD and RD were higher in progressors, and adding MFC MD improved prediction of radiographic progression (AUC 0.80 for JSN and 0.71 for KL).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Conclusion<\/jats:title>\n                    <jats:p>Baseline cartilage DTI, particularly MFC MD, showed stronger associations with early knee OA and radiographic progression than T2 mapping.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Evidence Level<\/jats:title>\n                    <jats:p>2.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Technical Efficacy<\/jats:title>\n                    <jats:p>Stage 3.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jmri.70562","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T08:42:08Z","timestamp":1790844128000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Diffusion Tensor Imaging of Knee Cartilage for Detection of Early Osteoarthritis and Prediction of Radiographic Progression"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7202-5712","authenticated-orcid":false,"given":"Jos\u00e9 G.","family":"Raya","sequence":"first","affiliation":[{"name":"Center for Biomedical Imaging, Department of Radiology New York University Grossman School of Medicine  New York New York USA"},{"name":"Tech4Health Institute New York University Langone Health  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitri","family":"Martel","sequence":"additional","affiliation":[{"name":"Center for Biomedical Imaging, Department of Radiology New York University Grossman School of Medicine  New York New York USA"},{"name":"Tech4Health Institute New York University Langone Health  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandra","family":"Duarte","sequence":"additional","affiliation":[{"name":"Division of Musculoskeletal Radiology, Department of Radiology Fundaci\u00f3n Santa Fe de Bogot\u00e1  Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny T.","family":"Bencardino","sequence":"additional","affiliation":[{"name":"Department of Radiology Montefiore Medical Center  Bronx New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svetlana","family":"Krasnokutsky\u2010Samuels","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Medicine NYU Grossman School of Medicine, NYU Langone Health  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1513-770X","authenticated-orcid":false,"given":"Jonathan","family":"Samuels","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Medicine NYU Grossman School of Medicine, NYU Langone Health  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Kijowski","sequence":"additional","affiliation":[{"name":"RadNet  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3947-4540","authenticated-orcid":false,"given":"Amparo","family":"Ruiz","sequence":"additional","affiliation":[{"name":"Center for Biomedical Imaging, Department of Radiology New York University Grossman School of Medicine  New York New York USA"},{"name":"Tech4Health Institute New York University Langone Health  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,1]]},"reference":[{"issue":"9","key":"e_1_2_8_2_1","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1002\/art.24021","article-title":"Lifetime Risk of Symptomatic Knee Osteoarthritis","volume":"59","author":"Murphy L.","year":"2008","journal-title":"Arthritis and Rheumatism"},{"issue":"5","key":"e_1_2_8_3_1","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.joca.2011.01.023","article-title":"Responsiveness to Change and Reliability of Measurement of Radiographic Joint Space Width in Osteoarthritis of the Knee: A Systematic Review","volume":"19","author":"Reichmann W. 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