{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T18:36:05Z","timestamp":1791225365023,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:00Z","timestamp":1791158400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:00Z","timestamp":1791158400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AR052784"],"award-info":[{"award-number":["R01 AR052784"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Ultrashort echo time T2* (UTE\u2010T2*) mapping is sensitive to the composition of deep cartilage and menisci. UTE\u2010T2* elevations are common after anterior cruciate ligament (ACL) injuries, but their long\u2010term prognostic importance is unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis<\/jats:title>\n                    <jats:p>Higher pre\u2010operative UTE\u2010T2* values will associate with greater symptoms and radiographic knee osteoarthritis (KOA) at long\u2010term follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Type<\/jats:title>\n                    <jats:p>Retrospective longitudinal cohort study using prospectively acquired baseline MRI and follow\u2010up clinical outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Population<\/jats:title>\n                    <jats:p>Twenty\u2010two participants (13 female, mean [SD] age: 29 [9] years) with ACL reconstruction (ACLR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Field Strength\/Sequence<\/jats:title>\n                    <jats:p>3T, 3D acquisition\u2010weighted stack of spirals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Assessment<\/jats:title>\n                    <jats:p>Pre\u2010operative UTE\u2010T2* maps from participants who underwent ACLR (2009\u20132012) were compared to 11\u2010year follow\u2010up Knee Injury and Osteoarthritis Outcome Scores (KOOS), the Marx Activity Rating Scale scores, and radiographs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Statistical Tests<\/jats:title>\n                    <jats:p>\n                      Linear regression models assessed relationships between pre\u2010operative cartilage and meniscus UTE\u2010T2* and follow\u2010up KOOS Symptoms or Marx scores. Mann\u2013Whitney\n                      <jats:italic>U<\/jats:italic>\n                      \u2010tests assessed differences in pre\u2010operative UTE\u2010T2* by radiographic KOA status (Kellgren\u2013Lawrence grade \u2265\u20092). Significance: two\u2010sided\n                      <jats:italic>\u03b1<\/jats:italic>\n                      \u2009&lt;\u20090.05.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      KOOS and Marx scores were available for 22 participants at a median of 11.3\u2009years (range: 10.3\u201312.4) after ACLR; radiographs were available for 11 participants. After adjustment for meniscus tear status, higher pre\u2010operative UTE\u2010T2* values in the deep medial femoral cartilage and medial meniscus were associated with worse KOOS Symptoms at 11\u2009years (adjusted\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.146\u20130.332). Higher femoral cartilage UTE\u2010T2* trended with lower Marx scores (adjusted\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.208,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.056), while higher posterior meniscus UTE\u2010T2* was associated with higher Marx scores (adjusted\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.308). In the small radiographic subset, median pre\u2010operative posterior meniscus UTE\u2010T2* was 69% higher in patients with radiographic KOA.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Conclusion<\/jats:title>\n                    <jats:p>Pre\u2010operative UTE\u2010T2* in medial compartment cartilage and menisci were associated with knee symptoms and activity levels 11\u2009years after ACLR. These findings support the potential utility of elevated cartilage and meniscus UTE\u2010T2* as markers of pre\u2010osteoarthritis reflecting symptomatic and structural KOA risk after ACLR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>Level 3.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Technical Efficacy<\/jats:title>\n                    <jats:p>Stage 3 Diagnostic Thinking.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jmri.70571","type":"journal-article","created":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T07:20:54Z","timestamp":1791184854000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Evaluation of Pre\u2010Operative Cartilage and Meniscus Ultrashort Echo Time\n                    <scp>T2<\/scp>\n                    * as Biomarkers of Long\u2010Term Clinical Outcomes Following Anterior Cruciate Ligament Reconstruction"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5845-7957","authenticated-orcid":false,"given":"Ashley A.","family":"Williams","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery Stanford University  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1506-0503","authenticated-orcid":false,"given":"Nicholas P.","family":"Drain","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8145-3308","authenticated-orcid":false,"given":"Jayme C. B.","family":"Koltsov","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Stanford University  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9931-7790","authenticated-orcid":false,"given":"Yongxian","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Radiology NYU Grossman School of Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4365-0241","authenticated-orcid":false,"given":"Kathryn J.","family":"Stevens","sequence":"additional","affiliation":[{"name":"Department of Radiology Stanford University  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4998-5846","authenticated-orcid":false,"given":"Constance R.","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Stanford University  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,5]]},"reference":[{"issue":"24","key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1136\/bjsports-2022-105496","article-title":"Risk Factors for Knee Osteoarthritis After Traumatic Knee Injury: A Systematic Review and meta\u2010Analysis of Randomised Controlled Trials and Cohort Studies for the OPTIKNEE Consensus","volume":"56","author":"Whittaker J. 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