{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T14:25:04Z","timestamp":1792074304870,"version":"4.4.0"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,6,4]],"date-time":"2013-06-04T00:00:00Z","timestamp":1370304000000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Medical Radiation Sci"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The use of technetium\u201099m 2\u2010methoxyisobutyl isonitrile (<jats:sup>99m<\/jats:sup>Tc <jats:styled-content style=\"fixed-case\">MIBI<\/jats:styled-content>) for assistance in minimally invasive radioguided surgery (<jats:styled-content style=\"fixed-case\">MIRS<\/jats:styled-content>) is growing in popularity as a safe, effective, and proficient technique used for parathyroidectomy in primary hyperparathyroidism (<jats:styled-content style=\"fixed-case\">PHPT<\/jats:styled-content>) treatment. Previously, the preferred treatment for <jats:styled-content style=\"fixed-case\">PHPT<\/jats:styled-content> was bilateral neck exploration (<jats:styled-content style=\"fixed-case\">BNE<\/jats:styled-content>), a very invasive, costly, and lengthy procedure. However, as a large majority (80\u201385% of cases of <jats:styled-content style=\"fixed-case\">PHPT<\/jats:styled-content>) are attributed to a single parathyroid adenoma (<jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content>), a simpler more direct technique such as <jats:styled-content style=\"fixed-case\">MIRS<\/jats:styled-content> is a far better option. The following article is an exploration of the current literature concerning varied protocols utilizing <jats:sup>99m<\/jats:sup>Tc <jats:styled-content style=\"fixed-case\">MIBI<\/jats:styled-content> for assistance in <jats:styled-content style=\"fixed-case\">MIRS<\/jats:styled-content> for patients undergoing treatment of <jats:styled-content style=\"fixed-case\">PHPT<\/jats:styled-content>. This technique boasts many advantageous outcomes for patients suffering from <jats:styled-content style=\"fixed-case\">PHPT<\/jats:styled-content>. These include a reduction in cost, operating time, and patient recovery; less evidence of post\u2010surgical hypocalcaemia, less pain, and complications; superior cosmetic results; same\u2010day discharge; and the possibility of local anaesthesia which is particularly beneficial in elderly patients. Better outcomes for patients with deep or ectopic <jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content>s, reduced intra\u2010operative complications, and improved cosmetic outcomes for patients who have previously undergone thyroid and\/or parathyroid surgery are also advantageous. Of the literature reviewed it was also found that no patients suffered any major surgical complications such as laryngeal nerve palsy or permanent hypoparathyroidism using <jats:sup>99m<\/jats:sup>Tc <jats:styled-content style=\"fixed-case\">MIBI<\/jats:styled-content> for assistance in <jats:styled-content style=\"fixed-case\">MIRS<\/jats:styled-content>.<\/jats:p>","DOI":"10.1002\/jmrs.14","type":"journal-article","created":{"date-parts":[[2013,6,4]],"date-time":"2013-06-04T05:59:02Z","timestamp":1370325542000},"page":"58-66","source":"Crossref","is-referenced-by-count":8,"title":["Use of <sup>99m<\/sup>Tc 2\u2010methoxyisobutyl isonitrile in minimally invasive radioguided surgery in patients with primary hyperparathyroidism: A narrative review of the current literature"],"prefix":"10.1002","volume":"60","author":[{"given":"Kristie A.","family":"Denmeade","sequence":"first","affiliation":[{"name":"Nuclear Medicine and Ultrasound Department Bankstown\u2010Lidcombe Hospital Bankstown New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Constable","sequence":"additional","affiliation":[{"name":"Brain and Mind Research Institute University of Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Warren M.","family":"Reed","sequence":"additional","affiliation":[{"name":"Discipline of Medical Radiation Sciences Faculty of Health Sciences The University of Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,6,4]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.285075055"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006231-200409000-00007"},{"key":"e_1_2_6_4_1","author":"Martini FH","year":"2006","journal-title":"Fundamentals of Anatomy & Physiology"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-007-0388-3"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200012213432508"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2004.10.008"},{"key":"e_1_2_6_8_1","first-page":"1","article-title":"FDG\u2010PET\/CT visualizes a case of primary hyperparathyroidism in a patient with gastrointestinal stromal tumour","volume":"5","author":"Evangelista L","year":"2010","journal-title":"Thyroid Sci"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03027403"},{"key":"e_1_2_6_10_1","unstructured":"Bristol\u2010Myers Squibb Medical Imaging.Cardiolite: Kit for the Preparation of Technetium [99mTc] Sestamibi for Injection[Product Brochure].MA 2003."},{"key":"e_1_2_6_11_1","first-page":"15","article-title":"99mTc\u2010DMSA (V) in dectection of metastases of medullary thyroid carcinoma","volume":"14","author":"Dabiri S","year":"2006","journal-title":"Iran J Nucl Med"},{"key":"e_1_2_6_12_1","author":"Ell PJ","year":"2004","journal-title":"Nuclear Medicine in Clinical Diagnosis and Treatment"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-004-7639-2"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1089\/cbr.2006.21.194"},{"key":"e_1_2_6_15_1","doi-asserted-by":"crossref","first-page":"S63","DOI":"10.1177\/030089160208800352","article-title":"99mTc\u2010MIBI radio\u2010guided surgery in primary hyperparathyroidism: A prospective study of 128 patients","volume":"88","author":"Rubello D","year":"2008","journal-title":"Tumori"},{"key":"e_1_2_6_16_1","first-page":"198","article-title":"99mTc\u2010sestamibi and minimally invasive radioguided surgery for primary hyperparathyroidism","volume":"46","author":"Wall H","year":"2005","journal-title":"J Nucl Med"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.139.4.433"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12149-010-0366-x"},{"key":"e_1_2_6_19_1","first-page":"99","article-title":"Minimally invasive 99mTc\u2010sestamibi radioguided surgery of parathyroid adenomas","volume":"47","author":"Rubello D","year":"2005","journal-title":"Panminerva Med"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003072-200210000-00006"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-006-0162-y"},{"key":"e_1_2_6_22_1","first-page":"904","article-title":"Incremental diagnostic value of preoperative (99m)Tc\u2010MIBI SPECT in patients with a parathyroid adenoma","volume":"44","author":"Lorberboym M","year":"2003","journal-title":"J Nucl Med"},{"key":"e_1_2_6_23_1","first-page":"13","article-title":"Minimally invasive radioguided surgery for parathyroid adenomas (MIRP)","volume":"20","author":"Somashekhar SP","year":"2007","journal-title":"Natl Med J India"},{"key":"e_1_2_6_24_1","first-page":"253","article-title":"Usefulness of preoperative 99mTc\u2010MIBI SPECT\u2010CT in primary hyperparathyroidism: Correlation with radioguided surgery findings","volume":"38","author":"Prieto Soriano A","year":"2011","journal-title":"Eur J Nucl Med Mol Imaging Conference: Annual Congress of the European Association of Nuclear Medicine 2011 Birmingham United Kingdom"},{"key":"e_1_2_6_25_1","first-page":"220","article-title":"Radioguided surgery of primary hyperparathyroidism using the low\u2010dose 99mTc\u2010sestamibi protocol: Multiinstitutional experience from the Italian Study Group on Radioguided Surgery and Immunoscintigraphy (GISCRIS)","volume":"46","author":"Rubello D","year":"2005","journal-title":"J Nucl Med"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000086546.68794.9a"},{"key":"e_1_2_6_27_1","first-page":"9","article-title":"Accurate planning of minimally invasive surgery of parathyroid adenomas by means of [(99m)Tc]MIBI SPECT","volume":"32","author":"Massaro A","year":"2007","journal-title":"Minerva Endocrinol"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7800-3-30"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.137.8.917"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2006.01.006"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-006-9254-y"},{"key":"e_1_2_6_32_1","volume-title":"Product price list","author":"GMS","year":"2012"},{"key":"e_1_2_6_33_1","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1177\/000313481107700621","article-title":"Use of a handheld, semiconductor (cadmium zinc telluride)\u2010based gamma camera in navigation surgery for primary hyperparathyroidism","volume":"77","author":"Fujii T","year":"2011","journal-title":"Am Surg"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-006-0250-z"}],"container-title":["Journal of Medical Radiation Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmrs.14","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmrs.14","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jmrs.14","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmrs.14","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T03:31:34Z","timestamp":1700623894000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmrs.14"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6]]},"references-count":33,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["10.1002\/jmrs.14"],"URL":"https:\/\/doi.org\/10.1002\/jmrs.14","archive":["Portico"],"relation":{},"ISSN":["2051-3895","2051-3909"],"issn-type":[{"value":"2051-3895","type":"print"},{"value":"2051-3909","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6]]}}}