{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T11:29:46Z","timestamp":1761823786225},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,2,15]],"date-time":"2016-02-15T00:00:00Z","timestamp":1455494400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Medical Radiation Sci"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>For patients receiving radiotherapy for locally advance non\u2013small cell lung cancer (<jats:styled-content style=\"fixed-case\">NSCLC<\/jats:styled-content>), the probability of experiencing severe radiation pneumonitis (<jats:styled-content style=\"fixed-case\">RP<\/jats:styled-content>) appears to rise with an increase in radiation received by the lungs. Intensity modulated radiotherapy (<jats:styled-content style=\"fixed-case\">IMRT<\/jats:styled-content>) provides the ability to reduce planned doses to healthy organs at risk (<jats:styled-content style=\"fixed-case\">OAR<\/jats:styled-content>) and can potentially reduce treatment\u2010related side effects. This study reports toxicity outcomes and provides a dosimetric comparison with three\u2010dimensional conformal radiotherapy (<jats:styled-content style=\"fixed-case\">3DCRT<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty curative <jats:styled-content style=\"fixed-case\">NSCLC<\/jats:styled-content> patients received radiotherapy using four\u2010dimensional computed tomography and five\u2010field <jats:styled-content style=\"fixed-case\">IMRT<\/jats:styled-content>. All were assessed for early and late toxicity using common terminology criteria for adverse events. All plans were subsequently re\u2010planned using <jats:styled-content style=\"fixed-case\">3DCRT<\/jats:styled-content> to the same standard as the clinical plans. Dosimetric parameters for lungs, oesophagus, heart and conformity were recorded for comparison between the two techniques.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">IMRT<\/jats:styled-content> plans achieved improved high\u2010dose conformity and reduced <jats:styled-content style=\"fixed-case\">OAR<\/jats:styled-content> doses including lung volumes irradiated to 5\u201320 Gy. One case each of oesophagitis and erythema (3%) were the only Grade 3 toxicities. Rates of Grade 2 oesophagitis were 40%. No cases of Grade 3 <jats:styled-content style=\"fixed-case\">RP<\/jats:styled-content> were recorded and Grade 2 <jats:styled-content style=\"fixed-case\">RP<\/jats:styled-content> rates were as low as 3%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">IMRT<\/jats:styled-content> provides a dosimetric benefit when compared to <jats:styled-content style=\"fixed-case\">3DCRT<\/jats:styled-content>. While the clinical benefit appears to increase with increasing target size and increasing complexity, <jats:styled-content style=\"fixed-case\">IMRT<\/jats:styled-content> appears preferential to <jats:styled-content style=\"fixed-case\">3DCRT<\/jats:styled-content> in the treatment of <jats:styled-content style=\"fixed-case\">NSCLC<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmrs.159","type":"journal-article","created":{"date-parts":[[2016,2,16]],"date-time":"2016-02-16T08:20:12Z","timestamp":1455610812000},"page":"170-178","source":"Crossref","is-referenced-by-count":7,"title":["Toxicity and dosimetric analysis of non\u2013small cell lung cancer patients undergoing radiotherapy with 4DCT and image\u2010guided intensity modulated radiotherapy: a regional centre's experience"],"prefix":"10.1002","volume":"63","author":[{"given":"Gareth C.","family":"Livingston","sequence":"first","affiliation":[{"name":"Port Macquarie Base Hospital Port Macquarie NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew J.","family":"Last","sequence":"additional","affiliation":[{"name":"Port Macquarie Base Hospital Port Macquarie NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas P.","family":"Shakespeare","sequence":"additional","affiliation":[{"name":"Coffs Harbour Health Campus Coffs Harbour NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick M.","family":"Dwyer","sequence":"additional","affiliation":[{"name":"Lismore Base Hospital Lismore NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin","family":"Westhuyzen","sequence":"additional","affiliation":[{"name":"Coffs Harbour Health Campus Coffs Harbour NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J.","family":"McKay","sequence":"additional","affiliation":[{"name":"Lismore Base Hospital Lismore NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Connors","sequence":"additional","affiliation":[{"name":"Lismore Base Hospital Lismore NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Leader","sequence":"additional","affiliation":[{"name":"Coffs Harbour Health Campus Coffs Harbour NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stuart","family":"Greenham","sequence":"additional","affiliation":[{"name":"Coffs Harbour Health Campus Coffs Harbour NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,2,15]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.26.2543"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2012.04.043"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0000000000000187"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2003.09.086"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2003.09.085"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2006.12.031"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2009.02.032"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1507-1367(10)60091-0"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2008.02.005"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1120\/jacmp.v7i4.2222"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/48\/12\/307"},{"key":"e_1_2_8_13_1","unstructured":"EviQ Cancer Treatments Online.Radiation oncology non\u2010small\u2010cell lung cancer (NSCLC) curative[Online].2014. 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