{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T17:59:27Z","timestamp":1720634367253},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,4,5]],"date-time":"2016-04-05T00:00:00Z","timestamp":1459814400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Medical Radiation Sci"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The aim of the study is to review the long\u2010term oncological outcomes and adverse effects of post\u2010operative radiotherapy (<jats:styled-content style=\"fixed-case\">PORT<\/jats:styled-content>) for Stage I\/<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> seminoma patients in an Australian radiation treatment centre.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a retrospective study of 125 patients with Stage I\/<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> seminoma treated with <jats:styled-content style=\"fixed-case\">PORT<\/jats:styled-content> at the Alfred Health Radiation Oncology Service between 1992 and 2013. Patients were linked to the Victorian Cancer Registry to enable confirmation of survival and diagnosis of secondary malignancies (<jats:styled-content style=\"fixed-case\">SM<\/jats:styled-content>). The relapse\u2010free survival (<jats:styled-content style=\"fixed-case\">RFS<\/jats:styled-content>), testicular\u2010cancer\u2010specific survival (<jats:styled-content style=\"fixed-case\">TCSS<\/jats:styled-content>), overall survival (<jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>) and <jats:styled-content style=\"fixed-case\">SM<\/jats:styled-content>\u2010free survival (<jats:styled-content style=\"fixed-case\">SMFS<\/jats:styled-content>) were estimated with Kaplan\u2013Meier methods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median age at diagnosis was 36 (range 20\u201362). The median time between diagnosis and <jats:styled-content style=\"fixed-case\">PORT<\/jats:styled-content> was 1.6 months (range: 0.5\u20134.5). Fifty patients (40%) had <jats:styled-content style=\"fixed-case\">PORT<\/jats:styled-content> to the para\u2010aortic (<jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content>) target alone, while the remaining had <jats:styled-content style=\"fixed-case\">PORT<\/jats:styled-content> to <jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content> and ipsilateral or bilateral iliac lymph nodes. There were no acute adverse effects requiring admission. The median follow\u2010up after <jats:styled-content style=\"fixed-case\">PORT<\/jats:styled-content> was 7.8 years (range = 0.1\u201319.1). There were two relapses, both of which occurred within 1 year of <jats:styled-content style=\"fixed-case\">PORT<\/jats:styled-content> (estimated 10\u2010year <jats:styled-content style=\"fixed-case\">RFS<\/jats:styled-content> = 98.4%). Five deaths were reported, none of which were testicular cancer\u2010related death (estimated 10\u2010year <jats:styled-content style=\"fixed-case\">TCSS<\/jats:styled-content> = 100%, 10\u2010year <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> = 97.3%). There were seven <jats:styled-content style=\"fixed-case\">SM<\/jats:styled-content> (one lower lip cancer, one upper shoulder melanoma, one mesothelioma, two prostate cancer, one acute myeloid leukaemia and one contralateral testicular seminoma) reported in six patients, with estimated 10\u2010year <jats:styled-content style=\"fixed-case\">SMFS<\/jats:styled-content> of 92.9%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our series confirms excellent oncological outcomes among patients with Stage I\/<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> seminoma treated with <jats:styled-content style=\"fixed-case\">PORT<\/jats:styled-content>, with uncommon occurrence of <jats:styled-content style=\"fixed-case\">SM<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmrs.170","type":"journal-article","created":{"date-parts":[[2016,4,10]],"date-time":"2016-04-10T13:16:15Z","timestamp":1460294175000},"page":"161-169","source":"Crossref","is-referenced-by-count":1,"title":["Long\u2010term outcomes following post\u2010operative radiotherapy for Stage I\/<scp>II<\/scp> testicular seminoma \u2013 an Australasian single\u2010institution experience"],"prefix":"10.1002","volume":"63","author":[{"given":"Wee Loon","family":"Ong","sequence":"first","affiliation":[{"name":"Alfred Health Radiation Oncology Service Prahran Victoria Australia"},{"name":"Department of Epidemiology and Preventive Medicine Monash University Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lester","family":"Nazareth","sequence":"additional","affiliation":[{"name":"Alfred Health Radiation Oncology Service Prahran Victoria 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