{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T13:05:33Z","timestamp":1754399133977,"version":"3.37.3"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,2,11]],"date-time":"2017-02-11T00:00:00Z","timestamp":1486771200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Medical Radiation Sci"],"published-print":{"date-parts":[[2017,3]]},"abstract":"Abstract<\/jats:title>Radiotherapy plays an important role in the treatment of early\u2010stage Hodgkin lymphoma, but late toxicities such as cardiovascular disease and second malignancy are a major concern. Our aim was to evaluate the potential of deep inspiration breath\u2010hold (DIBH<\/jats:styled-content>) and intensity\u2010modulated radiotherapy (IMRT<\/jats:styled-content>) to reduce cardiac dose from mediastinal radiotherapy. A 24 year\u2010old male with early\u2010stage bulky mediastinal Hodgkin lymphoma received involved\u2010site radiotherapy as part of a combined modality programme. Simulation was performed in free breathing (FB<\/jats:styled-content>) and DIBH<\/jats:styled-content>. The target and organs at risk were contoured on both datasets. Free breathing\u20103D conformal (FB<\/jats:styled-content>\u20103DCRT<\/jats:styled-content>), DIBH<\/jats:styled-content>\u20103DCRT<\/jats:styled-content>, FB<\/jats:styled-content>\u2010IMRT<\/jats:styled-content> and DIBH<\/jats:styled-content>\u2010IMRT<\/jats:styled-content> were compared with respect to target coverage and doses to organs at risk. A \u2018butterfly\u2019 IMRT<\/jats:styled-content> technique was used to minimise the low\u2010dose bath. In our patient, both DIBH<\/jats:styled-content> (regardless of mode of delivery) and IMRT<\/jats:styled-content> (in both FB<\/jats:styled-content> and DIBH<\/jats:styled-content>) achieved reductions in mean heart dose. DIBH<\/jats:styled-content> improved all lung parameters. IMRT<\/jats:styled-content> reduced high dose (V20), but increased low dose (V5) to lung. DIBH<\/jats:styled-content>\u2010IMRT<\/jats:styled-content> was chosen for treatment delivery. Advanced radiotherapy techniques have the potential to further optimise the therapeutic ratio in patients with mediastinal lymphoma. Benefits should be assessed on an individualised basis.<\/jats:p>","DOI":"10.1002\/jmrs.219","type":"journal-article","created":{"date-parts":[[2017,2,11]],"date-time":"2017-02-11T06:52:37Z","timestamp":1486795957000},"page":"69-75","source":"Crossref","is-referenced-by-count":6,"title":["A case study evaluating deep inspiration breath\u2010hold and intensity\u2010modulated radiotherapy to minimise long\u2010term toxicity in a young patient with bulky mediastinal Hodgkin lymphoma"],"prefix":"10.1002","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9598-699X","authenticated-orcid":false,"given":"Jonathan M.","family":"Tomaszewski","sequence":"first","affiliation":[{"name":"Ballarat Austin Radiation Oncology Centre Ballarat Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Crook","sequence":"additional","affiliation":[{"name":"Ballarat Austin Radiation Oncology Centre Ballarat Victoria 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