{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T00:30:34Z","timestamp":1765758634283,"version":"3.40.5"},"reference-count":10,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,3,6]],"date-time":"2021-03-06T00:00:00Z","timestamp":1614988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Medical Radiation Sci"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Most primary ocular adnexal lymphomas are those involving mucosa\u2010associated lymphoid tissue (MALT). Radiotherapy (RT) dose regimens in the literature vary from the historically used high doses (up to 56\u00a0Gy) to lower dose RT. We aimed to examine our institution\u2019s experience with the use of orbital RT for treating early\u2010stage primary ocular adnexal MALT lymphoma (POAML).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients treated for stage I or II POAML over a 12\u2010year period (July 2006 to June 2018) were identified through institutional databases. Data were retrospectively collated through review of patient records. Descriptive statistical methods were employed to analyse the data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighteen patients (median age of 67; range 44\u201087yrs) with localised POAML (3 cases of bilateral disease) were identified, resulting in a total of 21 evaluable orbits. Eight (44%) patients were female, and all were documented to be of good performance status (ECOG 0\u20101). The median follow\u2010up was 34\u00a0months (range 8\u201075\u00a0months). The commonest dose fractionation used was 20 Gy in 10 fractions (<jats:italic>n<\/jats:italic>\u00a0=\u00a013 orbits) and a 3D conformal or volumetric modulated arc therapy (VMAT) technique was used in the majority of cases. None of the patients experienced an in\u2010field recurrence. One patient had experienced a contralateral orbital recurrence two years post\u2010unilateral orbital RT for orbital MALT lymphoma. Three patients experienced distant relapse.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The use of lower dose orbital RT such as 20\u00a0Gy in 10 fractions (or radio biologically equivalent) yields excellent local disease control in the management of ocular adnexal MALT lymphoma. The durability of the response appears to be favourable. Given the indolent nature of the disease and the low levels of toxicity associated with lower dose orbital RT, this regimen remains our favoured approach to the management of localised POAML.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmrs.464","type":"journal-article","created":{"date-parts":[[2021,3,6]],"date-time":"2021-03-06T13:34:10Z","timestamp":1615037650000},"page":"269-273","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Examining the utility of lower dose radiotherapy for localised primary ocular adnexal MALT lymphoma"],"prefix":"10.1002","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6470-4483","authenticated-orcid":false,"given":"Sarah","family":"Leeson","sequence":"first","affiliation":[{"name":"Radiation Oncology Network, Western Sydney Local Health District Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jayasingham","family":"Jayamohan","sequence":"additional","affiliation":[{"name":"Radiation Oncology Network, Western Sydney Local Health District Sydney NSW Australia"},{"name":"Sydney Medical School University of Sydney Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanh","family":"Vu","sequence":"additional","affiliation":[{"name":"Radiation Oncology Network, Western Sydney Local Health District Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9151-0150","authenticated-orcid":false,"given":"Puma","family":"Sundaresan","sequence":"additional","affiliation":[{"name":"Radiation Oncology Network, Western Sydney Local Health District Sydney NSW Australia"},{"name":"Sydney Medical School University of Sydney Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,3,6]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2005.11.035"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-12-195453"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2010.08429.x"},{"key":"e_1_2_6_5_1","unstructured":"FreedmanA AsterJ.Clinical manifestations pathologic features and diagnosis of extranodal marginal zone lymphoma of mucosa associated lymphoid tissue (MALT). UpToDate. Topic 4733 Version 32.0; 2017. Available from:https:\/\/www.uptodate.com.acs.hcn.com.au\/contents\/clinical\u2010manifestations\u2010pathologic\u2010features\u2010and\u2010diagnosis\u2010of\u2010extranodal\u2010marginal\u2010zone\u2010lymphoma\u2010of\u2010mucosa\u2010associated\u2010lymphoid\u2010tissue\u2010malt?search=clinical%20manifestations%20pathologic%20features%20extranodal%20(MALT)%20lymphoma&source=search_result&selectedTitle=1~150&usage_type=default&display_rank=1#H130910870[Accessed 11.08.2018]."},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2011.03.050"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2009.04.018"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24717"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2013.04.035"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11539"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2015.01.009"}],"container-title":["Journal of Medical Radiation Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmrs.464","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jmrs.464","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmrs.464","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T17:00:29Z","timestamp":1693328429000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmrs.464"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,6]]},"references-count":10,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["10.1002\/jmrs.464"],"URL":"https:\/\/doi.org\/10.1002\/jmrs.464","archive":["Portico"],"relation":{},"ISSN":["2051-3895","2051-3909"],"issn-type":[{"type":"print","value":"2051-3895"},{"type":"electronic","value":"2051-3909"}],"subject":[],"published":{"date-parts":[[2021,3,6]]},"assertion":[{"value":"2020-11-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}