{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T00:16:21Z","timestamp":1792714581788,"version":"4.5.0"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,5,2]],"date-time":"2021-05-02T00:00:00Z","timestamp":1619913600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Medical Radiation Sci"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Stereotactic ablative body radiotherapy (SABR) is currently indicated for inoperable, early\u2010stage non\u2010small cell lung carcinoma (NSCLC). Advancements in image\u2010guidance technology continue to improve treatment precision and enable reductions in planning safety margins. We investigated the dosimetric benefits of margin reduction, its potential to extend SABR to more NSCLC patients and the factors influencing plan acceptability.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective analysis included 61 patients (stage IA\u2013IIIA) treated with conventional radiotherapy. Patients were ineligible for SABR due to tumour size or proximity to organs at risk (OAR). Using Pinnacle auto\u2010planning, three SABR plans were generated for each patient: a regular planning target volume margin plan, a reduced margin plan (gross tumour volume GTV+3\u00a0mm) and a non\u2010margin plan. Targets were planned to 48Gy\/4 or 50Gy\/5 fractions depending on location. Plans were compared in terms of target coverage, OAR doses and dosimetric acceptability based on local guidelines. Predictors of acceptability were investigated using logistic regression analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared to regular margin plans, both reduced margin and non\u2010margin plans resulted in significant reductions to almost all dose constraints. Dose conformity was significantly worse in non\u2010margin plans (<jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.05) and strongly correlated with targets\u2019 surface area\/volume ratio (<jats:italic>R<\/jats:italic><jats:sup>2\u00a0<\/jats:sup>=\u00a00.9, <jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.05). 26% of reduced margin plans were acceptable, compared to 54% of non\u2010margin plans. GTV overlap with OARs significantly affected plan acceptability (OR 0.008, 95% CI 0.001\u20130.073).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Margin reduction significantly reduced OAR doses enabling acceptable plans to be achieved for patients previously excluded from SABR. Indications for lung SABR may broaden as treatment accuracy continues to improve; further work is needed to identify patients most likely to benefit.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmrs.469","type":"journal-article","created":{"date-parts":[[2021,5,2]],"date-time":"2021-05-02T07:53:42Z","timestamp":1619942022000},"page":"298-309","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Can reducing planning safety margins broaden the inclusion criteria for lung stereotactic ablative body radiotherapy?"],"prefix":"10.1002","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9877-3268","authenticated-orcid":false,"given":"Wsam","family":"Ghandourh","sequence":"first","affiliation":[{"name":"South Western Clinical School Faculty of Medicine University of New South Wales Sydney New South Wales Australia"},{"name":"Liverpool and Macarthur Cancer Therapy Centres Sydney New South Wales Australia"},{"name":"Ingham Institute of Applied Medical Research Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikneswary","family":"Batumalai","sequence":"additional","affiliation":[{"name":"South Western Clinical School Faculty of Medicine University of New South Wales Sydney New South Wales Australia"},{"name":"Liverpool and Macarthur Cancer Therapy Centres Sydney New South Wales Australia"},{"name":"Ingham Institute of Applied Medical Research Sydney New South Wales Australia"},{"name":"Collaboration for Cancer Outcomes Research and Evaluation (CCORE) Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Boxer","sequence":"additional","affiliation":[{"name":"GenesisCare Concord Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lois","family":"Holloway","sequence":"additional","affiliation":[{"name":"South Western Clinical School Faculty of Medicine University of New South Wales Sydney New South Wales Australia"},{"name":"Liverpool and Macarthur Cancer Therapy Centres Sydney New South Wales Australia"},{"name":"Ingham Institute of Applied Medical Research Sydney New South Wales Australia"},{"name":"Centre for Medical Radiation Physics University of Wollongong Wollongong New South Wales Australia"},{"name":"Institute of Medical Physics School of Physics University of Sydney Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"crossref","unstructured":"VansteenkisteJ De RuysscherD EberhardtWEE LimE SenanS FelipE et\u00a0al.Early and locally advanced non\u2010small\u2010cell lung cancer (NSCLC): ESMO Clinical Practice Guidelines for diagnosis treatment and follow\u2010up 2013[cited 2019 Feb 28]. 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