{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T08:21:16Z","timestamp":1759134076402,"version":"3.40.5"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,7,30]],"date-time":"2022-07-30T00:00:00Z","timestamp":1659139200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100013741","name":"Royal Australian and New Zealand College of Radiologists","doi-asserted-by":"publisher","award":["2015\\RANZCR\\007"],"award-info":[{"award-number":["2015\\RANZCR\\007"]}],"id":[{"id":"10.13039\/100013741","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Medical Radiation Sci"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Anal cancer (AC) is <jats:sup>18<\/jats:sup>F\u2010FDG\u2010PET avid and has been used to evaluate treatment response several months after chemoradiotherapy. This pilot study aimed to assess the utility of semi\u2010automated contouring methods and quantitative measures of treatment response using <jats:sup>18<\/jats:sup>F\u2010FDG\u2010PET imaging at the early time point of 1\u2010month post\u2010chemoradiotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eleven patients with AC referred for chemoradiotherapy were prospectively enrolled into this study, with 10 meeting eligibility requirements. <jats:sup>18<\/jats:sup>F\u2010FDG\u2010PET imaging was obtained pre\u2010chemoradiotherapy (TP1), and then 1\u2010month (TP2), 3\u20136\u2009months (TP3) and 9\u201312\u2009months (TP4) post\u2010chemoradiotherapy. Manual and semi\u2010automated (Threshold) contouring methods were used to define the primary tumour on all <jats:sup>18<\/jats:sup>F\u2010FDG\u2010PET images. Resultant contours from each method were interrogated using quantitative measures, including volume, response index (RI), total lesion glycolysis (TLG), SUV<jats:sub>max<\/jats:sub>, SUV<jats:sub>median<\/jats:sub> and SUV<jats:sub>mean<\/jats:sub>. Response was assessed quantitatively as reductions in these measures and also qualitatively against established criteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nine patients were qualitatively classified as complete metabolic responders at TP2 and all 10 at TP3. All quantitative measures demonstrated significant (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) reductions at TP2 for both Manual and Threshold methods. All reduced further at TP3 and again at TP4 for Threshold methods. TLG showed the highest reduction at all post\u2010chemoradiotherapy time points and classified the most responders for each method at each time point. All patients are recurrence\u2010free at minimum 4\u2010year follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Based on our small sample size, semi\u2010automated methods of disease definition using <jats:sup>18<\/jats:sup>F\u2010FDG\u2010PET imaging are feasible and appear to facilitate quantitative response classification of AC as early as 1\u2010month post\u2010chemoradiotherapy. Early identification of treatment response may potentially improve disease management.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmrs.611","type":"journal-article","created":{"date-parts":[[2022,7,30]],"date-time":"2022-07-30T07:58:27Z","timestamp":1659167907000},"page":"439-447","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A pilot study investigating the role of <scp><sup>18<\/sup>F\u2010FDG\u2010PET<\/scp> in the early identification of chemoradiotherapy response in anal cancer"],"prefix":"10.1002","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7378-8586","authenticated-orcid":false,"given":"Drew","family":"Smith","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Olivia Newton\u2010John Cancer Wellness &amp; Research Centre Austin Health  Heidelberg Victoria Australia"},{"name":"Department of Medical Imaging and Radiation Sciences Monash University  Clayton Victoria 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