{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T13:35:21Z","timestamp":1790948121014,"version":"4.1.0"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009812","name":"Princess Margaret Cancer Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009812","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Medical Radiation Sci"],"published-print":{"date-parts":[[2023,3]]},"abstract":"Abstract<\/jats:title>Introduction<\/jats:title>We conducted a study to evaluate the dosimetric feasibility of mask\u2010based cobalt\u201060 fractionated stereotactic radiotherapy (mcfSRT<\/jats:styled-content>) with the Leksell Gamma Knife\u00ae Icon\u2122 device.<\/jats:p><\/jats:sec>Methods<\/jats:title>Eleven patients with intracranial tumours were selected for this dosimetry study. These patients, previously treated with volumetric arc therapy (VMAT<\/jats:styled-content>), were re\u2010planned using mcfSRT<\/jats:styled-content>. Target volume coverage, conformity\/gradient indices, doses to organs at risk and treatment times were compared between the mcfSRT<\/jats:styled-content> and VMAT<\/jats:styled-content> plans. Two\u2010sided paired Wilcoxon signed\u2010rank test was used to compare differences between the two plans.<\/jats:p><\/jats:sec>Results<\/jats:title>The V95<\/jats:styled-content> for PTV<\/jats:styled-content> was similar between fractionated mcfSRT<\/jats:styled-content> and VMAT<\/jats:styled-content> (P<\/jats:italic>\u2009=\u20090.47). The conformity index and gradient indices were 0.9 and 3.3, respectively, for mcfSRT<\/jats:styled-content> compared to 0.7 and 4.2, respectively, for VMAT<\/jats:styled-content> (P<\/jats:italic>\u2009<\u20090.001 and 0.004, respectively). The radiation exposure to normal brain was lower for mcfSRT<\/jats:styled-content> across V10<\/jats:styled-content>, V25<\/jats:styled-content> and V50<\/jats:styled-content> compared with VMAT<\/jats:styled-content> (P<\/jats:italic>\u2009=\u20090.007, <0.001 and <0.001, respectively). The median D0<\/jats:styled-content>.1cc for optic nerve and chiasm as well as the median D50<\/jats:styled-content> to the hippocampi were lower for mcfSRT<\/jats:styled-content> compared to VMAT<\/jats:styled-content>. Median beam\u2010on time for mcfSRT<\/jats:styled-content> was 9.7\u2009min per fraction, compared to 0.9\u2009min for VMAT<\/jats:styled-content> (P<\/jats:italic>\u2009=\u20090.002).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>mcfSRT<\/jats:styled-content> plans achieve equivalent target volume coverage, improved conformity and gradient indices, and reduced radiation doses to organs at risk as compared with VMAT<\/jats:styled-content> plans. These results suggest superior dosimetric parameters for mcfSRT<\/jats:styled-content> plans and can form the basis for future prospective studies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmrs.615","type":"journal-article","created":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T07:40:31Z","timestamp":1664610031000},"page":"64-71","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Dosimetric evaluation of adult and paediatric brain tumours planned using mask\u2010based cobalt\u201060 fractionated stereotactic radiotherapy compared to linear accelerator\u2010based volumetric modulated arc therapy"],"prefix":"10.1002","volume":"70","author":[{"given":"Chin Heng","family":"Fong","sequence":"first","affiliation":[{"name":"Radiation Medicine Program Princess Margaret Cancer Centre, University Health Network Toronto Ontario 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Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young\u2010Bin","family":"Cho","sequence":"additional","affiliation":[{"name":"Radiation Medicine Program Princess Margaret Cancer Centre, University Health Network Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David B.","family":"Shultz","sequence":"additional","affiliation":[{"name":"Radiation Medicine Program Princess Margaret Cancer Centre, University Health Network Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9762-6901","authenticated-orcid":false,"given":"Derek S.","family":"Tsang","sequence":"additional","affiliation":[{"name":"Radiation Medicine Program Princess Margaret Cancer Centre, University Health Network Toronto Ontario 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