{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:47:16Z","timestamp":1786978036457,"version":"build-2736575974"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T00:00:00Z","timestamp":1676419200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Medical Radiation Sci"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Adjuvant radiotherapy is an established component in the management of metastatic cutaneous squamous cell carcinoma (SCC) involving the parotid gland. Radiotherapy technique, dose and volumes are seldom described sufficiently to allow close examination. We report our treatment outcomes and focus on treatment\u2010related factors that affect outcomes in this cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a retrospective review of patients with metastatic cutaneous SCCs who underwent parotidectomy with or without ipsilateral neck dissection. All patients received adjuvant radiotherapy. Demographics, clinical data and treatment details were collected from an intuitional electronic database. Individual patient\u2010level radiotherapy technique, volumes and doses were reviewed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Between July 2008 and July 2018, 60 patients met our inclusion criteria. Median follow\u2010up duration was 32.7\u2009months. The mean age was 66.4\u2009years. The majority of patients (49 patients) received full neck irradiation. The 2\u2010year and 5\u2010year loco\u2010regional failure\u2010free survival was 87% (95% confidence interval (CI): 0.74\u20130.93) and 71% (95% CI: 0.52, 0.83), respectively. The 2\u2010year and 5\u2010year overall survival was 76% (95% CI: 0.62, 0.85) and 60% (95% CI: 0.45, 0.72), respectively. There were 15 cases of loco\u2010regional failures, with 6 cases with dermal involvement. Lymphovascular invasion (LVI) was associated with higher loco\u2010regional failure (hazard ratio: 8.43, 95% CI: 1.85\u201338.39,\n                      <jats:italic>P\u2009=<\/jats:italic>\n                      \u00a00.005) and cancer\u2010specific mortality (hazard ratio: 5.40, 95% CI: 1.40\u201320.87,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.015). Treatment technique, intensity\u2010modulated radiation therapy (IMRT) vs 3D conformal radiotherapy (3D CRT), bolus use, perineural invasion (PNI) and surgical margins were not significantly associated with loco\u2010regional failure.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We demonstrated high loco\u2010regional control rates with routine use of comprehensive adjuvant radiotherapy. The presence of LVI was identified as a strong predictor for recurrence. Further analysis will help to define optimal radiation dose and techniques.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jmrs.650","type":"journal-article","created":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T07:19:41Z","timestamp":1676445581000},"page":"161-170","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Metastatic cutaneous squamous cell carcinoma to the parotid: Adjuvant radiotherapy and treatment outcomes"],"prefix":"10.1002","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6399-7122","authenticated-orcid":false,"given":"Marcus","family":"Hu","sequence":"first","affiliation":[{"name":"Townsville Cancer Centre Townsville Hospital and Health Service  Townsville Queensland Australia"},{"name":"Faculty of Medicine University of Queensland  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna N. H.","family":"Kim","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Queensland  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3282-1861","authenticated-orcid":false,"given":"Theophilus I.","family":"Emeto","sequence":"additional","affiliation":[{"name":"Public Health &amp; Tropical Medicine, College of Public Health, Medical &amp; Veterinary Sciences James Cook University  Townsville Queensland Australia"},{"name":"Australian Institute of Tropical Health and Medicine James Cook University  Townsville Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Collins","sequence":"additional","affiliation":[{"name":"Townsville Cancer Centre Townsville Hospital and Health Service  Townsville Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Chopping","sequence":"additional","affiliation":[{"name":"Townsville Cancer Centre Townsville Hospital and Health Service  Townsville Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Lin","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Queensland  Brisbane Queensland Australia"},{"name":"Department of Radiation Oncology Royal Brisbane and Women's Hospital  Herston Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,2,15]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.2006.tb00086.x"},{"key":"e_1_2_9_3_1","volume-title":"Skin cancer in Australia","author":"Australian Institute of Health and 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