{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:22:54Z","timestamp":1747149774939,"version":"3.40.5"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T00:00:00Z","timestamp":1687219200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Medical Radiation Sci"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Breast magnetic resonance imaging (MRI) is increasingly being used for staging of patients with breast cancer due to its high sensitivity in detecting additional cancers (ACs). However, the clinical impact of diagnosing and treating these cancers remains unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective study was undertaken of patients with newly diagnosed breast cancer who underwent staging MRI at The American University of Beirut Medical Centre (AUBMC) between 2012 and 2020. Pathology reports and breast MRI examinations were reviewed. Eighteen breast cancer patients with 19 pathology\u2010proven index cancers (ICs) and 19 pathology\u2010proven MRI\u2010detected ACs were included. Chi\u2010square and Fisher's exact tests for categorical variables and Wilcoxon signed rank test for numerical variables were used to compare ICs to ACs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The ICs consisted of four ductal carcinoma in situ (DCIS), 13 invasive ductal carcinomas (IDC), of which five with associated DCIS, and two invasive lobular carcinomas, (ILC) of which one with associated DCIS. ACs comprised 12 DCIS, five IDC, two with associated DCIS and two ILC, one with associated DCIS. Interval cancers were more frequently invasive whereas ACs were more frequently in situ (<jats:italic>P<\/jats:italic>\u2009=\u20090.021). ACs were more frequently nuclear grade 2 (<jats:italic>P<\/jats:italic>\u2009=\u20090.009). There was no statistically significant difference between ICs and ACs in lesion type (<jats:italic>P<\/jats:italic>\u2009=\u20090.062), shape (<jats:italic>P<\/jats:italic>\u2009=\u20090.073), initial enhancement (<jats:italic>P<\/jats:italic>\u2009=\u20091), delayed enhancement (<jats:italic>P<\/jats:italic>\u2009=\u20090.732), hormonal receptor profile (<jats:italic>P<\/jats:italic>\u2009=\u20090.68) and Ki67 (<jats:italic>P<\/jats:italic>\u2009=\u20090.388). Among ACs, ten (53%) were larger than 10\u2009mm of which five (26%) were invasive cancers, and five (26%) were larger than the ICs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>ACs detected by breast MRI were more likely to be in situ and to show a nuclear grade 2. Although not reaching statistical significance, some ACs tend to be clinically significant by their type, size or nuclear grade. The impact on clinical management remains to be determined.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmrs.694","type":"journal-article","created":{"date-parts":[[2023,6,21]],"date-time":"2023-06-21T06:00:04Z","timestamp":1687327204000},"page":"360-368","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Additional occult cancers identified on staging breast MRI: imaging appearances and pathologic characteristics"],"prefix":"10.1002","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4076-2224","authenticated-orcid":false,"given":"Lara","family":"Nassar","sequence":"first","affiliation":[{"name":"Department of Diagnostic Radiology American University of Beirut Medical Center  Beirut Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanaa","family":"Nakad","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology\/Division of Gynecologic Oncology The University of Chicago  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farah","family":"Abou Zeid","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology American University of Beirut Medical Center  Beirut Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeina","family":"Farah","sequence":"additional","affiliation":[{"name":"Ministry of Public Health\u2010Epidemiological Surveillance Program  Beirut Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ghida","family":"Saheb","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology American University of Beirut Medical Center  Beirut Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nayla","family":"Mroueh","sequence":"additional","affiliation":[{"name":"Department of Radiology\/Division of Abdominal Imaging Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Debs","sequence":"additional","affiliation":[{"name":"The Russel H. Morgan Department of Radiology and Radiological Science The Johns Hopkins School of Medicine  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ghina","family":"Berjawi","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology American University of Beirut Medical Center  Beirut Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,6,20]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.388"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2442060461"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLI.0b013e3181f3fcdf"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2016.07.020"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-015-3556-3"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.08.1551"},{"key":"e_1_2_11_8_1","unstructured":"ACR Practice Parameter for the Performance of Magnetic Resonance Imaging\u2013Guided Breast Interventional Procedures.ACRPublished online Revised 2021. 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