{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T11:04:47Z","timestamp":1785150287103,"version":"3.55.0"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T00:00:00Z","timestamp":1761436800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T00:00:00Z","timestamp":1761436800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Medical Radiation Sci"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Systematic and random errors in radiation dose delivery necessitate the use of planning target volume (PTV) margins to ensure adequate clinical target volume (CTV) treatment. Advances in magnetic resonance\u2010guided radiation therapy (MRgRT) have enabled improved imaging with possible margin reduction; however, the optimal PTV margins remain uncertain. This study aimed to evaluate the adaptive radiotherapy component of intra\u2010fractional prostate movement in MRgRT for prostate cancer (PCa) patients and determine appropriate PTV margins.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study retrospectively analyzed 18 PCa patients treated using a 1.5\u2009T MR\u2010Linac. The initial fusion MR and verification MR scans were registered offline to assess prostate displacement between the two scans in the anterior\u2013posterior (AP), left\u2010right (LR) and superior\u2010inferior (SI) directions. Random and systematic errors were calculated, and the PTV margins were determined using the Van Herk formula.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The average time between MR scans was 22\u2009min (range 9\u201354\u2009min) compared to an average beam\u2010on time of 6\u2009min (range 2\u201311\u2009min). Mean and standard deviation of translational displacement was 1.2\u2009\u00b1\u20090.9\u2009mm in the AP, 0.6\u2009\u00b1\u20090.5\u2009mm in the LR, and 1.1\u2009\u00b1\u20090.8\u2009mm in the SI directions. The calculated PTV margin was 3.2\u2009mm in AP, 1.7\u2009mm in LR, and 3.2\u2009mm in SI directions. There was an observed trend of increased prostate motion with increased treatment duration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>MRgRT facilitates PTV margin reduction for PCa; however, our findings suggest that increased on\u2010couch time may be associated with greater prostate motion. Future studies with larger patient cohorts and real\u2010time motion monitoring are recommended to optimise margin strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jmrs.70033","type":"journal-article","created":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T05:45:01Z","timestamp":1761543901000},"page":"44-51","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Magnetic Resonance Guided Radiation Therapy (\n                    <scp>MRgRT<\/scp>\n                    ) Prostate Motion and Margins"],"prefix":"10.1002","volume":"73","author":[{"given":"Sammi","family":"Peng","sequence":"first","affiliation":[{"name":"Department of Medical Imaging and Radiation Sciences, School of Primary and Allied Health Care Monash University  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tegan","family":"Courtot","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Olivia Newton\u2010John Cancer Wellness and Research Centre  Heidelberg Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Lye","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Olivia Newton\u2010John Cancer Wellness and Research Centre  Heidelberg Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8387-0965","authenticated-orcid":false,"given":"Farshad","family":"Foroudi","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Olivia Newton\u2010John Cancer Wellness and Research Centre  Heidelberg Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Tacey","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Olivia Newton\u2010John Cancer Wellness and Research Centre  Heidelberg Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1947-9694","authenticated-orcid":false,"given":"Daryl Lim","family":"Joon","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Olivia Newton\u2010John Cancer Wellness and Research Centre  Heidelberg Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Chao","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Olivia Newton\u2010John Cancer Wellness and Research Centre  Heidelberg Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ee Siang","family":"Choong","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Olivia Newton\u2010John Cancer Wellness and Research Centre  Heidelberg Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,26]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2023.04.021"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/03915603211042335"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2019.03.051"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2018.8006"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.3635"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000486988"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2020202747"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.21037\/tau.2017.12.37"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.meddos.2005.12.004"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12094\u2010009\u20100413\u2010z"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2010.02.001"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20160312"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.21037\/qims-21-697"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15184657"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2016.04.014"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.3109\/0284186X.2015.1062541"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2023.109761"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2022.08.041"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2022.6558"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/pro6.1155"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1337626"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13014-020-01604-5"},{"key":"e_1_2_12_24_1","unstructured":"G. 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